Cryo-EM structure of human apo GPR156
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8yjp
Q-score: 0.396
Ma X, Chen LN, Liao M, Zhang L, Xi K, Guo J, Shen C, Shen DD, Cai P, Shen Q, Qi J, Zhang H, Zang SK, Dong YJ, Miao L, Qin J, Ji SY, Li Y, Liu J, Mao C, Zhang Y, Chai R
Nat Commun (2024) 15 pp. 10601-10601 [ Pubmed: 39638804 DOI: doi:10.1038/s41467-024-54681-5 ]
- Probable g-protein coupled receptor 156 (38 kDa, Protein from Homo sapiens)
- (21r,24r,27s)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9z)-octadec-9-enoate (777 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Gpr156 (Cellular component from Homo sapiens)
Cryo-EM structure of human GPR156-Gi3 complex
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8yk0
Q-score: 0.501
Ma X, Chen LN, Liao M, Zhang L, Xi K, Guo J, Shen C, Shen DD, Cai P, Shen Q, Qi J, Zhang H, Zang SK, Dong YJ, Miao L, Qin J, Ji SY, Li Y, Liu J, Mao C, Zhang Y, Chai R
Nat Commun (2024) 15 pp. 10601-10601 [ Pubmed: 39638804 DOI: doi:10.1038/s41467-024-54681-5 ]
- Probable g-protein coupled receptor 156 (35 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Bos taurus)
- (21r,24r,27s)-24,27,28-trihydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaoctacosan-21-yl (9z)-octadec-9-enoate (777 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 156 (32 kDa, Protein from Homo sapiens)
- Gpr156-gi3 complex (Cellular component from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of the [Pyr1]-apelin-13-bound human APLNR-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xzg
Q-score: 0.495
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Apelin-13 (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the [pyr1]-apelin-13-bound human aplnr-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the WN561-bound human APLNR-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xzf
Q-score: 0.578
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Wn561 (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the wn561-bound human aplnr-gi complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the MM07-bound human APLNR-Gi complex
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8xzh
Q-score: 0.649
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Mm07 (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the mm07-bound human aplnr-gi complex (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from synthetic construct)
Cryo-EM structure of the CMF-019-bound human APLNR-Gi complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8xzi
Q-score: 0.588
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- (3~{s})-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazol-5-yl]carbonylamino]hexanoic acid (455 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the cmf-019-bound human aplnr-gi complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the WN353-bound human APLNR-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xzj
Q-score: 0.509
Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y
Cell (2024) 187 pp. 1460-1475.e20 [ DOI: doi:10.1016/j.cell.2024.02.004 Pubmed: 38428423 ]
- Cryo-em structure of the wn353-bound human aplnr-gi complex (Complex from Homo sapiens)
- Apelin receptor (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Wn353 (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Cryo-EM structure of the inactive CD97
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ikj
Q-score: 0.301
Cryo-EM structure of the CD97-G13 complex
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 8ikl
Q-score: 0.59
Mao C, Zhao RJ, Dong YJ, Gao M, Chen LN, Zhang C, Xiao P, Guo J, Qin J, Shen DD, Ji SY, Zang SK, Zhang H, Wang WW, Shen Q, Sun JP, Zhang Y
Mol Cell (2024) 84 pp. 570-583.e7 [ Pubmed: 38215752 DOI: doi:10.1016/j.molcel.2023.12.020 ]
- Adhesion g protein-coupled receptor e5 (Cellular component from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(13) subunit alpha isoforms short (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Adhesion g protein-coupled receptor e5 (31 kDa, Protein from Homo sapiens)
Cryo-EM structure of the TRH-bound human TRHR-Gq complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7xw9
Q-score: 0.543
Ji SY, Dong YJ, Chen LN, Zang SK, Wang J, Shen DD, Guo J, Qin J, Zhang H, Wang WW, Shen Q, Zhang Y, Song Z, Mao C
Cell Discov (2022) 8 pp. 116-116 [ DOI: doi:10.1038/s41421-022-00477-0 Pubmed: 36280665 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of the trh-bound trhr-gq complex (180 kDa, Complex)
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)
- Antibody (Complex from synthetic construct)
- G protein (Complex from Homo sapiens)
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (46 kDa, Protein from Homo sapiens)
- Trh peptide (362 Da, Protein from synthetic construct)
- Trh peptide (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Thyrotropin-releasing hormone receptor (Complex from Homo sapiens)