Cryo-EM structure of the tethered agonist-bound human PAR1-Gq complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xor
Q-score: 0.513
Guo J, Zhou YL, Yang Y, Guo S, You E, Xie X, Jiang Y, Mao C, Xu HE, Zhang Y
Cell Res (2024) 34 pp. 725-734 [ Pubmed: 38997424 DOI: doi:10.1038/s41422-024-00997-2 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Proteinase-activated receptor 1 lgbit (58 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus)
- Gi1-gq chimeric (Complex from Mus musculus)
- G(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- G(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Scfv16 (32 kDa, Protein from Mus musculus)
- Cryo-em structure of ligand-bound form of the receptor in complex with the transducer (Complex from Rattus)
- Scfv16 (Complex from Homo sapiens)
- G subunit q (gi1-gq chimeric) (41 kDa, Protein from Homo sapiens)
- Proteinase-activated receptor 1 (Complex)
Human KCNQ2-CaM in complex with HN37
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8izy
Q-score: 0.529
Structure of ATP7B C983S/C985S/D1027A mutant with AMP-PNP
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8ioy
Q-score: 0.381
Yang GM, Xu L, Wang RM, Tao X, Zheng ZW, Chang S, Ma D, Zhao C, Dong Y, Wu S, Guo J, Wu ZY
Cell Rep (2023) 42 pp. 112417-112417 [ Pubmed: 37074913 DOI: doi:10.1016/j.celrep.2023.112417 ]
- Copper-transporting atpase 2 (162 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Complex of atp7b and anp (Complex from Homo sapiens)
Cryo-EM structure of the TRH-bound human TRHR-Gq complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7xw9
Q-score: 0.543
Ji SY, Dong YJ, Chen LN, Zang SK, Wang J, Shen DD, Guo J, Qin J, Zhang H, Wang WW, Shen Q, Zhang Y, Song Z, Mao C
Cell Discov (2022) 8 pp. 116-116 [ DOI: doi:10.1038/s41421-022-00477-0 Pubmed: 36280665 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of the trh-bound trhr-gq complex (180 kDa, Complex)
- Single fab chain (svfv16) (28 kDa, Protein from synthetic construct)
- Antibody (Complex from synthetic construct)
- G protein (Complex from Homo sapiens)
- Thyrotropin-releasing hormone receptor (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (46 kDa, Protein from Homo sapiens)
- Trh peptide (362 Da, Protein from synthetic construct)
- Trh peptide (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Thyrotropin-releasing hormone receptor (Complex from Homo sapiens)
CryoEM structure of human KChIP1-Kv4.3-DPP6 complex
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 7w6t
Q-score: 0.25
Ma D, Zhao C, Wang X, Li X, Zha Y, Zhang Y, Fu G, Liang P, Guo J, Lai D
Cell Res (2022) 32 pp. 411-414 [ Pubmed: 34997220 DOI: doi:10.1038/s41422-021-00608-4 ]
- Complex of voltage-gated potassium channel kv4.3 with auxiliary subunits kchip1 and dpp6 (Complex from Homo sapiens)
- Kv channel-interacting protein 1 (26 kDa, Protein from Homo sapiens)
- Dipeptidyl aminopeptidase-like protein 6 (98 kDa, Protein from Mus musculus)
- Isoform 2 of potassium voltage-gated channel subfamily d member 3 (71 kDa, Protein from Homo sapiens)
Cryo-EM structure of alpha-MSH-bound melanocortin-1 receptor in complex with Gs protein and Nb35
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7f4d
Q-score: 0.478
Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE
Cell Res (2021) 31 pp. 1061-1071 [ Pubmed: 34453129 DOI: doi:10.1038/s41422-021-00557-y ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Melanocortin-1 receptor (68 kDa, Protein from Homo sapiens)
- Cryo-em structure of alpha-msh-bound melanocortin-1 receptor in complex with gs protein and nb35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Melanocortin-1 receptor (Complex)
- Nanobody 35 (17 kDa, Protein from synthetic construct)
- Alpha-melanocyte-stimulating hormone (Complex)
- Alpha-melanocyte-stimulating hormone (1 kDa, Protein from synthetic construct)
- Calcium ion (40 Da, Ligand)
- Nanobody 35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7f4f
Q-score: 0.509
Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE
Cell Res (2021) 31 pp. 1061-1071 [ Pubmed: 34453129 DOI: doi:10.1038/s41422-021-00557-y ]
- Afamelanotide (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex)
- Melanocortin-1 receptor (68 kDa, Protein from Homo sapiens)
- Cryo-em structure of afamelanotide-bound melanocortin-1 receptor in complex with gs protein and scfv16 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Melanocortin-1 receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Afamelanotide (1 kDa, Protein from synthetic construct)
- Scfv16 (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7f4h
Q-score: 0.52
Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE
Cell Res (2021) 31 pp. 1061-1071 [ Pubmed: 34453129 DOI: doi:10.1038/s41422-021-00557-y ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from synthetic construct)
- Afamelanotide (Complex)
- Cryo-em structure of afamelanotide-bound melanocortin-1 receptor in complex with gs protein, nb35 and scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Scfv16 (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Melanocortin-1 receptor (68 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Afamelanotide (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from synthetic construct)
- Melanocortin-1 receptor (Complex from synthetic construct)
- Calcium ion (40 Da, Ligand)
- Nanobody 35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
Cryo-EM structure of SHU9119-bound melanocortin-1 receptor in complex with Gs protein and Nb35
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7f4i
Q-score: 0.474
Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE
Cell Res (2021) 31 pp. 1061-1071 [ Pubmed: 34453129 DOI: doi:10.1038/s41422-021-00557-y ]
- Melanocortin-1 receptor (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Shu9119 (1 kDa, Protein from synthetic construct)
- Melanocortin-1 receptor (68 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (17 kDa, Protein from synthetic construct)
- Shu9119 (Complex)
- Calcium ion (40 Da, Ligand)
- Nanobody 35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Cryo-em structure of shu9119-bound melanocortin-1 receptor in complex with gs protein and nb35 (Complex from Homo sapiens)