cryoEM structure of SARS-CoV2 Spike trimer in complex with Fab23
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8q5y
Q-score: 0.516
Mandolesi M, Das H, de Vries L, Yang Y, Kim C, Dhinakaran M, Castro Dopico X, Fischbach J, Kim S, Guryleva MV, Adori M, Chernyshev M, Stalmarck A, Hanke L, McInerney GM, Sheward DJ, Corcoran M, Hallberg BM, Murrell B, Karlsson Hedestam GB
Nat Commun (2024) 15 pp. 6338-6338 [ DOI: doi:10.1038/s41467-024-50286-0 Pubmed: 39068149 ]
- Monoclonal antibody mab 23 (heavy chain) (48 kDa, Protein from Homo sapiens)
- Monoclonal antibody mab 23 (light chain) (23 kDa, Protein from Homo sapiens)
- Sars-cov2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV2 Omicron BA.1 RBD in complex with CAB-A17 antibody
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8c0y
Q-score: 0.491
Sheward DJ, Pushparaj P, Das H, Greaney AJ, Kim C, Kim S, Hanke L, Hyllner E, Dyrdak R, Lee J, Dopico XC, Dosenovic P, Peacock TP, McInerney GM, Albert J, Corcoran M, Bloom JD, Murrell B, Karlsson Hedestam GB, Hallberg BM
Cell Rep Med (2024) 5 pp. 101577-101577 [ DOI: doi:10.1016/j.xcrm.2024.101577 Pubmed: 38761799 ]
- Sars-cov-2 omicron rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s2' (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cab-a17 antibody (variable) (12 kDa, Protein from Homo sapiens)
- Cab-a17 antibody (fab) (Complex from Enterobacteria phage T4)
- Sars-cov2 omicron ba.1 spike in complex with cab-a17 antibody (95 kDa, Complex)
- Cab-a17 antibody (variable) (11 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike RBD in complex with Mab-23 (Fab)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8p5m
Q-score: 0.554
Mandolesi M, Das H, de Vries L, Yang Y, Kim C, Dhinakaran M, Castro Dopico X, Fischbach J, Kim S, Guryleva MV, Adori M, Chernyshev M, Stalmarck A, Hanke L, McInerney GM, Sheward DJ, Corcoran M, Hallberg BM, Murrell B, Karlsson Hedestam GB
Nat Commun (2024) 15 pp. 6338-6338 [ DOI: doi:10.1038/s41467-024-50286-0 Pubmed: 39068149 ]
- Sars-cov-2 spike (rbd) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Mab-23 (heavy chain variable domain) (48 kDa, Protein from Homo sapiens)
- Monoclonal antibody mab-23 (Complex from Enterobacteria phage T4)
- Spike rbd (two molecules) in complex with two fu2 nanobodies (95 kDa, Complex)
- Mab-23 (light chain variable domain) (23 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Model and map from local refinement of a CAB-A17 - Omicron Ba.1 spike complex
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8v4f
Q-score: 0.513
Sheward DJ, Pushparaj P, Das H, Greaney AJ, Kim C, Kim S, Hanke L, Hyllner E, Dyrdak R, Lee J, Dopico XC, Dosenovic P, Peacock TP, McInerney GM, Albert J, Corcoran M, Bloom JD, Murrell B, Karlsson Hedestam GB, Hallberg BM
Cell Rep Med (2024) 5 pp. 101577-101577 [ DOI: doi:10.1016/j.xcrm.2024.101577 Pubmed: 38761799 ]
- Complex between fab preparation of cab-a17 and omicron ba.1 spike (Complex from Homo sapiens)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cab-a17 variable light chain (11 kDa, Protein from Homo sapiens)
- Cab-a17 variable heavy-chain (12 kDa, Protein from Homo sapiens)
SARS-CoV2 Omicron BA.1 spike in complex with CAB-A17 antibody
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8c2r
Q-score: 0.436
Sheward DJ, Pushparaj P, Das H, Greaney AJ, Kim C, Kim S, Hanke L, Hyllner E, Dyrdak R, Lee J, Dopico XC, Dosenovic P, Peacock TP, McInerney GM, Albert J, Corcoran M, Bloom JD, Murrell B, Karlsson Hedestam GB, Hallberg BM
Cell Rep Med (2024) 5 pp. 101577-101577 [ DOI: doi:10.1016/j.xcrm.2024.101577 Pubmed: 38761799 ]
- Cab-a17 antibody (lc) (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cab-a17 antibody (fab) (Complex from Enterobacteria phage T4)
- Sars-cov2 omicron ba.1 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov2 omicron ba.1 spike in complex with cab-a17 antibody (95 kDa, Complex)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cab-a17 antibody (hc) (22 kDa, Protein from Homo sapiens)
SARS Cov2 Spike in 1-up conformation complex with Fab47
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8a99
Q-score: 0.33
Pushparaj P, Nicoletto A, Sheward DJ, Das H, Castro Dopico X, Perez Vidakovics L, Hanke L, Chernyshev M, Narang S, Kim S, Fischbach J, Ekstrom S, McInerney G, Hallberg BM, Murrell B, Corcoran M, Karlsson Hedestam GB
Immunity (2023) 56 pp. 193-206.e7 [ Pubmed: 36574772 DOI: doi:10.1016/j.immuni.2022.12.005 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov2 spike 1-up conformation in complex with fab47 (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab47 (light chain variable domain) (11 kDa, Protein from Homo sapiens)
- Fab47 (heavy chain variable domain) (13 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike 1-up conformation in complex with fab47 (629 MDa, Complex from Homo sapiens)
SARS-CoV-2 Spike RBD (dimer) in complex with two Fu2 nanobodies
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7nll
Q-score: 0.522
Hanke L, Das H, Sheward DJ, Perez Vidakovics L, Urgard E, Moliner-Morro A, Kim C, Karl V, Pankow A, Smith NL, Porebski B, Fernandez-Capetillo O, Sezgin E, Pedersen GK, Coquet JM, Hallberg BM, Murrell B, McInerney GM
Nat Commun (2022) 13 pp. 155-155 [ DOI: doi:10.1038/s41467-021-27610-z Pubmed: 35013189 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nanobody fu2 (Complex from Vicugna pacos)
- Nanobody fu2 (15 kDa, Protein from Vicugna pacos)
- Spike protein s1 (25 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Receptor binding domain of sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike rbd (two molecules) in complex with two fu2 nanobodies (35 kDa, Complex)
Nanobody E bound to Spike-RBD in a localized reconstruction.
Resolution: 3.79 Å
EM Method: Single-particle
Fitted PDBs: 7b14
Q-score: 0.216
Koenig PA, Das H, Liu H, Kummerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Todtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hallberg BM, Wu NC, Schmidt FI
Science (2021) 371 [ Pubmed: 33436526 DOI: doi:10.1126/science.abe6230 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 glycoprotein in complex with a nanobody named v (510 kDa, Complex)
- Nanobody against sars-cov-2 (Complex from Camelus bactrianus)
- Nanobody against sars-cov-2 (14 kDa, Protein from Camelus bactrianus)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-spike bound to two neutralising nanobodies
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 7b18
Q-score: 0.397
Koenig PA, Das H, Liu H, Kummerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Todtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hallberg BM, Wu NC, Schmidt FI
Science (2021) 371 [ Pubmed: 33436526 DOI: doi:10.1126/science.abe6230 ]
- Sars-cov-2 glycoprotein in complex with two nanobodys named v (510 kDa, Complex)
- Nanobody against sars-cov-2 vhh e (Complex from Lama glama)
- Nanobody against spike glycoprotein vhh v (12 kDa, Protein from Vicugna pacos)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nanobody against spike glycoprotein vhh v (Complex from Vicugna pacos)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Nanobody against sars-cov-2 vhh e (14 kDa, Protein from Lama glama)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-spike RBD bound to two neutralising nanobodies
Resolution: 4.01 Å
EM Method: Single-particle
Fitted PDBs: 7b17
Q-score: 0.272
Koenig PA, Das H, Liu H, Kummerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Todtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hallberg BM, Wu NC, Schmidt FI
Science (2021) 371 [ Pubmed: 33436526 DOI: doi:10.1126/science.abe6230 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of sars-cov-2 spike rbd in complex with sars-cov-2 neutralizing biparatopic nanobody ve (300 kDa, Complex)
- Sars-cov-2 neutralizing biparatopic nanobody ve,nanobody e from lama glama,sars-cov-2 neutralizing biparatopic nanobody ve,nanobody e from lama glama (30 kDa, Protein from Lama glama)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Biparatopic nanobody ve (Complex from Vicugna pacos)