SARS-CoV2 Omicron BA.1 RBD in complex with CAB-A17 antibody
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8c0y
Q-score: 0.491
Sheward DJ, Pushparaj P, Das H, Greaney AJ, Kim C, Kim S, Hanke L, Hyllner E, Dyrdak R, Lee J, Dopico XC, Dosenovic P, Peacock TP, McInerney GM, Albert J, Corcoran M, Bloom JD, Murrell B, Karlsson Hedestam GB, Hallberg BM
Cell Rep Med (2024) 5 pp. 101577-101577 [ DOI: doi:10.1016/j.xcrm.2024.101577 Pubmed: 38761799 ]
- Sars-cov-2 omicron rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s2' (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cab-a17 antibody (variable) (12 kDa, Protein from Homo sapiens)
- Cab-a17 antibody (fab) (Complex from Enterobacteria phage T4)
- Sars-cov2 omicron ba.1 spike in complex with cab-a17 antibody (95 kDa, Complex)
- Cab-a17 antibody (variable) (11 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike RBD in complex with Mab-23 (Fab)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8p5m
Q-score: 0.554
Mandolesi M, Das H, de Vries L, Yang Y, Kim C, Dhinakaran M, Castro Dopico X, Fischbach J, Kim S, Guryleva MV, Adori M, Chernyshev M, Stalmarck A, Hanke L, McInerney GM, Sheward DJ, Corcoran M, Hallberg BM, Murrell B, Karlsson Hedestam GB
Nat Commun (2024) 15 pp. 6338-6338 [ DOI: doi:10.1038/s41467-024-50286-0 Pubmed: 39068149 ]
- Sars-cov-2 spike (rbd) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Mab-23 (heavy chain variable domain) (48 kDa, Protein from Homo sapiens)
- Monoclonal antibody mab-23 (Complex from Enterobacteria phage T4)
- Spike rbd (two molecules) in complex with two fu2 nanobodies (95 kDa, Complex)
- Mab-23 (light chain variable domain) (23 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV2 Omicron BA.1 spike in complex with CAB-A17 antibody
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8c2r
Q-score: 0.436
Sheward DJ, Pushparaj P, Das H, Greaney AJ, Kim C, Kim S, Hanke L, Hyllner E, Dyrdak R, Lee J, Dopico XC, Dosenovic P, Peacock TP, McInerney GM, Albert J, Corcoran M, Bloom JD, Murrell B, Karlsson Hedestam GB, Hallberg BM
Cell Rep Med (2024) 5 pp. 101577-101577 [ DOI: doi:10.1016/j.xcrm.2024.101577 Pubmed: 38761799 ]
- Cab-a17 antibody (lc) (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cab-a17 antibody (fab) (Complex from Enterobacteria phage T4)
- Sars-cov2 omicron ba.1 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov2 omicron ba.1 spike in complex with cab-a17 antibody (95 kDa, Complex)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cab-a17 antibody (hc) (22 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike RBD (dimer) in complex with two Fu2 nanobodies
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 7nll
Q-score: 0.522
Hanke L, Das H, Sheward DJ, Perez Vidakovics L, Urgard E, Moliner-Morro A, Kim C, Karl V, Pankow A, Smith NL, Porebski B, Fernandez-Capetillo O, Sezgin E, Pedersen GK, Coquet JM, Hallberg BM, Murrell B, McInerney GM
Nat Commun (2022) 13 pp. 155-155 [ DOI: doi:10.1038/s41467-021-27610-z Pubmed: 35013189 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nanobody fu2 (Complex from Vicugna pacos)
- Nanobody fu2 (15 kDa, Protein from Vicugna pacos)
- Spike protein s1 (25 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Receptor binding domain of sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike rbd (two molecules) in complex with two fu2 nanobodies (35 kDa, Complex)
SARS-CoV-2 Spike (dimers) in complex with six Fu2 nanobodies
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 7ns6
Q-score: 0.372
Hanke L, Das H, Sheward DJ, Perez Vidakovics L, Urgard E, Moliner-Morro A, Kim C, Karl V, Pankow A, Smith NL, Porebski B, Fernandez-Capetillo O, Sezgin E, Pedersen GK, Coquet JM, Hallberg BM, Murrell B, McInerney GM
Nat Commun (2022) 13 pp. 155-155 [ DOI: doi:10.1038/s41467-021-27610-z Pubmed: 35013189 ]
- Fu2 nanobody (15 kDa, Protein from Vicugna pacos)
- Fu2 nanobody (Complex from Vicugna pacos)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike rbd (two molecules) in complex with two fu2 nanobodies (95 kDa, Complex)
- Sars-cov-2 spike, fibritin (Complex from Enterobacteria phage T4)
- Spike glycoprotein,fibritin (142 kDa, Protein from Enterobacteria phage T4)
Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23)
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 7a25
Q-score: 0.386
Custodio TF, Das H, Sheward DJ, Hanke L, Pazicky S, Pieprzyk J, Sorgenfrei M, Schroer MA, Gruzinov AY, Jeffries CM, Graewert MA, Svergun DI, Dobrev N, Remans K, Seeger MA, McInerney GM, Murrell B, Hallberg BM, Low C
Nat Commun (2020) 11 pp. 5588-5588 [ Pubmed: 33149112 DOI: doi:10.1038/s41467-020-19204-y ]
- Sars-cov-2 spike glycoprotein in 1-up conformation bound by 3 neutralising sybodies (sb23) (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Neutralising sybody (sb23) (Complex from synthetic construct)
- Sybody 23 (12 kDa, Protein from synthetic construct)
- Spike glycoprotein (126 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 7a29
Q-score: 0.398
Custodio TF, Das H, Sheward DJ, Hanke L, Pazicky S, Pieprzyk J, Sorgenfrei M, Schroer MA, Gruzinov AY, Jeffries CM, Graewert MA, Svergun DI, Dobrev N, Remans K, Seeger MA, McInerney GM, Murrell B, Hallberg BM, Low C
Nat Commun (2020) 11 pp. 5588-5588 [ Pubmed: 33149112 DOI: doi:10.1038/s41467-020-19204-y ]
- Sars-cov-2 spike glycoprotein in 1-up conformation bound by 3 neutralising sybodies (sb23) (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Neutralising sybody (sb23) (Complex from synthetic construct)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Neutralising sybody (sb23) (12 kDa, Protein from synthetic construct)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing nanobodies (Ty1)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 6zxn
Q-score: 0.468
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hallberg BM, Murrell B, McInerney GM
Nat Commun (2020) 11 pp. 4420-4420 [ Pubmed: 32887876 DOI: doi:10.1038/s41467-020-18174-5 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nanobody strongly neutralising and blocks ace2 binding. (Complex from Severe acute respiratory syndrome coronavirus 2)
- Nanobody ty1 (Complex from Vicugna pacos)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Nanobody ty1 (14 kDa, Protein from Vicugna pacos)
- Ternary complex between nanobody ty1 and spike. (14 kDa, Complex)
SARS-CoV-2 spike glycoprotein bound to nanobodies (Ty1)
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, Corcoran M, Achour A, Karlsson Hedestam GB, Hallberg BM, Murrell B, McInerney GM
Nat Commun (2020) 11 pp. 4420-4420 [ Pubmed: 32887876 DOI: doi:10.1038/s41467-020-18174-5 ]