EMDB < Search results

EMBL

was set up in 1974 as Europe’s flagship laboratory for the life sciences – an intergovernmental organisation with more than 80 independent research groups covering the spectrum of molecular biology:

Research:

perform basic research in molecular biology

Services:

offer vital services to scientists in the member states

Training

scientists, students and visitors at all levels

Transfer

and development of technology

Develop

new instruments and methods

Integrating

life science research in Europe

More about EMBL

Six sites

represent EMBL in Europe.

Barcelona

Tissue biology and disease modelling

Grenoble

Structural biology

Hamburg

Structural biology

Heidelberg

Main laboratory

Hinxton

EMBL-EBI: European Bioinformatics Institute

Rome

Epigenetics and neurobiology

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primary_citation_author:"Halls ML" AND author_name:"Andrea" AND xref_links:"pdb"

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EMD-45492

Composite map Download Map 3D View

Structure of the TSC:WIPI3 lysosomal recruitment complex

Release date: Dec. 4, 2024
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9ce3
Q-score: 0.382

Bayly-Jones C, Lupton CJ, D'Andrea L, Chang YG, Jones GD, Steele JR, Venugopal H, Schittenhelm RB, Halls ML, Ellisdon AM

Sci Adv (2024) 10 pp. eadr5807-eadr5807 [ Pubmed: 39565846 DOI: doi:10.1126/sciadv.adr5807 ]

Sample:

Isoform 4 of tuberin (199 kDa, Protein from Homo sapiens)
Tbc1 domain family member 7 (35 kDa, Protein from Homo sapiens)
Wd repeat domain phosphoinositide-interacting protein 3 (35 kDa, Protein from Homo sapiens)
Tsc:wipi3 lysosomal recruitment complex (composite map) (733 kDa, Complex from Homo sapiens)
Unknown fragment (1 kDa, Protein from Homo sapiens)
Hamartin (133 kDa, Protein from Homo sapiens)

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EMD-25524

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Reconstruction of full-length Prex-1 (PtdIns(3,4,5)P3-dependent Rac Exchanger 1)

Release date: July 27, 2022
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7syf
Q-score: 0.205

Chang YG, Lupton CJ, Bayly-Jones C, Keen AC, D'Andrea L, Lucato CM, Steele JR, Venugopal H, Schittenhelm RB, Whisstock JC, Halls ML, Ellisdon AM

Nat Struct Mol Biol (2022) 29 pp. 767-773 [ Pubmed: 35864164 DOI: doi:10.1038/s41594-022-00804-9 ]

Sample:

Phosphatidylinositol 3,4,5-trisphosphate-dependent rac exchanger 1 protein,endolysin chimera (191 kDa, Protein from Homo sapiens)
Full-length prex-1 (ptdins(3,4,5)p3-dependent rac exchanger 1) (191 kDa, Complex from Homo sapiens)

EMD-23924

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Neurofibromin core

Release date: Dec. 15, 2021
Resolution: 4.56 Å
EM Method: Single-particle
Fitted PDBs: 7moc
Q-score: 0.278

Lupton CJ, Bayly-Jones C, D'Andrea L, Huang C, Schittenhelm RB, Venugopal H, Whisstock JC, Halls ML, Ellisdon AM

Nat Struct Mol Biol (2021) 28 pp. 982-988 [ DOI: doi:10.1038/s41594-021-00687-2 Pubmed: 34887559 ]

Sample:

Isoform i of neurofibromin (318 kDa, Protein from Homo sapiens)
Neurofibromin (636 kDa, Complex from Homo sapiens)

EMD-23929

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Autoinhibited neurofibrobmin

Release date: Dec. 15, 2021
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 7mp5
Q-score: 0.145

Lupton CJ, Bayly-Jones C, D'Andrea L, Huang C, Schittenhelm RB, Venugopal H, Whisstock JC, Halls ML, Ellisdon AM

Nat Struct Mol Biol (2021) 28 pp. 982-988 [ DOI: doi:10.1038/s41594-021-00687-2 Pubmed: 34887559 ]

Sample:

Isoform i of neurofibromin (318 kDa, Protein from Homo sapiens)
Neurofibromin (636 kDa, Complex from Homo sapiens)

EMD-23930

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Neurofibromin homodimer

Release date: Dec. 15, 2021
Resolution: 6.25 Å
EM Method: Single-particle
Fitted PDBs: 7mp6
Q-score: 0.14

Lupton CJ, Bayly-Jones C, D'Andrea L, Huang C, Schittenhelm RB, Venugopal H, Whisstock JC, Halls ML, Ellisdon AM

Nat Struct Mol Biol (2021) 28 pp. 982-988 [ DOI: doi:10.1038/s41594-021-00687-2 Pubmed: 34887559 ]

Sample:

Isoform i of neurofibromin (318 kDa, Protein from Homo sapiens)
Neurofibromin homodimer (630 kDa, Complex from Homo sapiens)

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EMDB [5]

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