Cryo-EM structure of the Serotonin 6 (5-HT6) receptor-DNGs-scFv16 complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7ys6
Q-score: 0.429
He L, Zhao QY, Qi J, Wang Y, Han W, Chen Z, Cong Y, Wang S
PNAS (2023) 120 pp. e2209917120-e2209917120 [ DOI: doi:10.1073/pnas.2209917120 Pubmed: 36989299 ]
- 5-hydroxytryptamine receptor 6 (33 kDa, Protein from Homo sapiens)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Serotonin (176 Da, Ligand)
- Serotonin 6 (5-ht6) receptor-dngs-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
SARS-CoV-2 Omicron open state spike protein in complex with S3H3 Fab
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 7wk9
Q-score: 0.204
Hong Q, Han W, Li J, Xu S, Wang Y, Xu C, Li Z, Wang Y, Zhang C, Huang Z, Cong Y
Nature (2022) 604 pp. 546-552 [ Pubmed: 35228716 DOI: doi:10.1038/s41586-022-04581-9 ]
- Sars-cov-2 omicron open state spike protein in complex with s3h3 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of s3h3 fab (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of s3h3 fab (23 kDa, Protein from Mus musculus)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7wk2
Q-score: 0.293
Hong Q, Han W, Li J, Xu S, Wang Y, Xu C, Li Z, Wang Y, Zhang C, Huang Z, Cong Y
Nature (2022) 604 pp. 546-552 [ Pubmed: 35228716 DOI: doi:10.1038/s41586-022-04581-9 ]
- Omicron s-close (Complex from Mus musculus)
- Omicron s-close (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein (Complex from Mus musculus)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Omicron s-close (Complex)
- Sars-cov-2 omicorn varient (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Omicron spike protein SD1 in complex with S3H3 Fab
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 7wk8
Q-score: 0.466
Hong Q, Han W, Li J, Xu S, Wang Y, Xu C, Li Z, Wang Y, Zhang C, Huang Z, Cong Y
Nature (2022) 604 pp. 546-552 [ Pubmed: 35228716 DOI: doi:10.1038/s41586-022-04581-9 ]
- Heavy chain of s3h3 fab (23 kDa, Protein from Mus musculus)
- Light chain of s3h3 fab (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 omicron spike in complex with s3h3 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 Omicron closed state spike protein in complex with S3H3 Fab
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 7wka
Q-score: 0.182
Hong Q, Han W, Li J, Xu S, Wang Y, Xu C, Li Z, Wang Y, Zhang C, Huang Z, Cong Y
Nature (2022) 604 pp. 546-552 [ Pubmed: 35228716 DOI: doi:10.1038/s41586-022-04581-9 ]
- Heavy chain of s3h3 fab (23 kDa, Protein from Mus musculus)
- Sars-cov-2 omicron closed state spike protein in complex with s3h3 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of s3h3 fab (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7dcc
Q-score: 0.137
Zhang C, Wang Y, Zhu Y, Liu C, Gu C, Xu S, Wang Y, Zhou Y, Wang Y, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z
Nat Commun (2021) 12 pp. 264-264 [ DOI: doi:10.1038/s41467-020-20465-w Pubmed: 33431876 ]
- The heavy chain of 3c1 fab (24 kDa, Protein from Mus musculus)
- Complex of sarc-cov2-s protein with 3c1 fab, all the three rbds are in the up conformation and each of them associates with a 3c1 fab (Complex from Mus musculus)
- The light chain of 3c1 fab (23 kDa, Protein from Mus musculus)
- 3c1 fab with a heavy chain and a light chain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sarc-cov2-s protein (Complex)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
S-3C1-F3a structure, two RBDs are up and one RBD is down, each RBD binds with a 3C1 fab.
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 7dcx
Q-score: 0.087
Zhang C, Wang Y, Zhu Y, Liu C, Gu C, Xu S, Wang Y, Zhou Y, Wang Y, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z
Nat Commun (2021) 12 pp. 264-264 [ DOI: doi:10.1038/s41467-020-20465-w Pubmed: 33431876 ]
- The light chain of 3c1 fab (23 kDa, Protein from Mus musculus)
- 3c1 fab with a heavy chain and a light chain (Complex from Severe acute respiratory syndrome coronavirus 2)
- The heavy chain of 3c1 fab that binds with the up rbd (24 kDa, Protein from Mus musculus)
- Sars-cov2-s protein (Complex)
- Complex of sars-cov2-s protein with 3c1 fab, two rbds are up and one rbd is down (Complex from Mus musculus)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
S-3C1-F2 structure, two RBDs are up and one RBD is down, the two up RBD bind with a 3C1 fab.
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 7dd2
Q-score: 0.1
Zhang C, Wang Y, Zhu Y, Liu C, Gu C, Xu S, Wang Y, Zhou Y, Wang Y, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z
Nat Commun (2021) 12 pp. 264-264 [ DOI: doi:10.1038/s41467-020-20465-w Pubmed: 33431876 ]
- The heavy chain of 3c1 fab (24 kDa, Protein from Mus musculus)
- 3c1 fab with a heavy chain and a light chain (Complex)
- The light chain of 3c1 fab (23 kDa, Protein from Mus musculus)
- Complex of sars-cov2-s protein with 3c1 fab, two rbds are up and one rbd is down, only the two up rbds bind with a 3c1 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov2-s protein (Complex from Mus musculus)
S-3C1-F1 structure, one RBD is up and two RBDs are down, the up RBD binds with a 3C1 fab
Resolution: 7.5 Å
EM Method: Single-particle
Fitted PDBs: 7dd8
Q-score: 0.081
Zhang C, Wang Y, Zhu Y, Liu C, Gu C, Xu S, Wang Y, Zhou Y, Wang Y, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z
Nat Commun (2021) 12 pp. 264-264 [ DOI: doi:10.1038/s41467-020-20465-w Pubmed: 33431876 ]
- The heavy chain of 3c1 fab (24 kDa, Protein from Mus musculus)
- The light chain of 3c1 chain (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 3c1 fab with a heavy chain and a light chain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Complex of sars-cov2-s protein with 3c1 fab, one rbd is up and two rbds are down, the up rbd binds with a 3c1 fab (Complex from Mus musculus)
- Sars-cov2-s protein (Complex)
S-2H2-F3a structure, two RBDs are up and one RBD is down, each RBD binds with a 2H2 Fab.
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7dk4
Q-score: 0.244
Zhang C, Wang Y, Zhu Y, Liu C, Gu C, Xu S, Wang Y, Zhou Y, Wang Y, Han W, Hong X, Yang Y, Zhang X, Wang T, Xu C, Hong Q, Wang S, Zhao Q, Qiao W, Zang J, Kong L, Wang F, Wang H, Qu D, Lavillette D, Tang H, Deng Q, Xie Y, Cong Y, Huang Z
Nat Commun (2021) 12 pp. 264-264 [ DOI: doi:10.1038/s41467-020-20465-w Pubmed: 33431876 ]
- 2h2 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 s protein (Complex)
- Complex of sars-cov-2 s protein with 2h2 fab, two rbds are up and one rbd is down (Complex from Mus musculus)
- The heavy chain of 2h2 fab (22 kDa, Protein from Mus musculus)
- The light chain of 2h2 fab (23 kDa, Protein from Mus musculus)