Cryo-EM structure of human proteasome assembly intermediate preholo-1
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8yiy
Q-score: 0.431
Han Y, Han Q, Tang Q, Zhang Y, Liu K
Sci Adv (2025) 11 pp. eadr7943-eadr7943 [ Pubmed: 39792683 DOI: doi:10.1126/sciadv.adr7943 ]
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (27 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Cryo-em structure of human proteasome assembly intermediate preholo-1 (Complex from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome maturation protein (15 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of human proteasome assembly intermediate preholo-2
Resolution: 3.79 Å
EM Method: Single-particle
Fitted PDBs: 8yiz
Q-score: 0.393
Han Y, Han Q, Tang Q, Zhang Y, Liu K
Sci Adv (2025) 11 pp. eadr7943-eadr7943 [ Pubmed: 39792683 DOI: doi:10.1126/sciadv.adr7943 ]
- Proteasome subunit beta type-7 (30 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (27 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Cryo-em structure of human proteasome assembly intermediate preholo-2 (Complex from Homo sapiens)
Connexin-43 gap junction channel in complex with mefloquine
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 8qko
Q-score: 0.313
Lavriha P, Han Y, Ding X, Schuster D, Qi C, Vaithia A, Picotti P, Korkhov VM
PLoS One (2024) 19 pp. e0315510-e0315510 [ DOI: doi:10.1371/journal.pone.0315510 Pubmed: 39739741 ]
Plasmodium falciparum 20S proteasome bound to an inhibitor
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8w2f
Q-score: 0.576
Lawong A, Gahalawat S, Ray S, Ho N, Han Y, Ward KE, Deng X, Chen Z, Kumar A, Xing C, Hosangadi V, Fairhurst KJ, Tashiro K, Liszczak G, Shackleford DM, Katneni K, Chen G, Saunders J, Crighton E, Casas A, Robinson JJ, Imlay LS, Zhang X, Lemoff A, Zhao Z, Angulo-Barturen I, Jimenez-Diaz MB, Wittlin S, Campbell SF, Fidock DA, Laleu B, Charman SA, Ready JM, Phillips MA
Cell Chem Biol (2024) 31 pp. 1503- [ DOI: doi:10.1016/j.chembiol.2024.07.001 Pubmed: 39084225 ]
- Proteasome endopeptidase complex (28 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (33 kDa, Protein from Plasmodium falciparum 3D7)
- (3s)-1-[(2-fluoroethoxy)acetyl]-n-{[(4p)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide (420 Da, Ligand)
- Proteasome subunit beta (25 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (24 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta type (23 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome endopeptidase complex (26 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit alpha type (28 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta type-6, putative (29 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (22 kDa, Protein from Plasmodium falciparum 3D7)
- Plasmodium falciparum 20s proteasome bound with an inhibitor (750 kDa, Complex from Plasmodium falciparum 3D7)
- Proteasome subunit beta (27 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit alpha type-3, putative (29 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome endopeptidase complex (29 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum 3D7)
TFIIIA-TFIIIC-Brf1-TBP complex bound to 5S rRNA gene
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8ffz
Q-score: 0.333
Talyzina A, Han Y, Banerjee C, Fishbain S, Reyes A, Vafabakhsh R, He Y
Mol Cell (2023) 83 pp. 2641- [ DOI: doi:10.1016/j.molcel.2023.06.015 Pubmed: 37402369 ]
- Zinc ion (65 Da, Ligand)
- Transcription factor tau 95 kda subunit (73 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor tau 55 kda subunit (49 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor tau 91 kda subunit (74 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor iiia (52 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor tau 131 kda subunit (120 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor tau 138 kda subunit (132 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor iiib 70 kda subunit,tata-box-binding protein (82 kDa, Protein from Saccharomyces cerevisiae S288C)
- Dna (151-mer) (52 kDa, DNA from Saccharomyces cerevisiae)
- Dna (151-mer) (52 kDa, DNA from Saccharomyces cerevisiae)
- Tfiiia-tfiiic-brf1-tbp complex bound to 5srrna gene (810 MDa, Complex from Saccharomyces cerevisiae)
- Transcription factor tau 60 kda subunit (67 kDa, Protein from Saccharomyces cerevisiae)
Cryo-EM structure of the SARS-CoV-2 S-6P in complex with BD-368-2 Fabs
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 7chh
Q-score: -0.009
Du S, Cao Y, Zhu Q, Yu P, Qi F, Wang G, Du X, Bao L, Deng W, Zhu H, Liu J, Nie J, Zheng Y, Liang H, Liu R, Gong S, Xu H, Yisimayi A, Lv Q, Wang B, He R, Han Y, Zhao W, Bai Y, Qu Y, Gao X, Ji C, Wang Q, Gao N, Huang W, Wang Y, Xie XS, Su XD, Xiao J, Qin C
Cell (2020) 183 pp. 1013-1023.e13 [ Pubmed: 32970990 DOI: doi:10.1016/j.cell.2020.09.035 ]
- Complex of the sars-cov-2 s-6p with bd-368-2 fabs (Complex)
- Bd-368-2 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bd-368-2 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (133 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Bd-368-2 fabs (Complex from Homo sapiens)
MCU holocomplex in High-calcium state
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 6xjv
Q-score: 0.31
Wang Y, Han Y, She J, Nguyen NX, Mootha VK, Bai XC, Jiang Y
eLife (2020) 9 [ DOI: doi:10.7554/eLife.60513 Pubmed: 32762847 ]
- Calcium uptake protein 1, mitochondrial (54 kDa, Protein from Homo sapiens)
- Calcium uptake protein 2, mitochondrial (49 kDa, Protein from Homo sapiens)
- Calcium uniporter protein, mitochondrial (39 kDa, Protein from Homo sapiens)
- Essential mcu regulator, mitochondrial (11 kDa, Protein from Homo sapiens)
- Mcu/emre/micu1/micu2 complex (529 kDa, Complex from Homo sapiens)
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 6uxv
Q-score: 0.322
Han Y, Reyes AA, Malik S, He Y
Nature (2020) 579 pp. 452-455 [ DOI: doi:10.1038/s41586-020-2087-1 Pubmed: 32188938 ]
- Swi/snf body module (Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Unknown protein (2 kDa, Protein from Saccharomyces cerevisiae S288C)
- Swi/snf global transcription activator complex subunit swp82 (7 kDa, Protein from Saccharomyces cerevisiae S288C)
- Unknown protein (2 kDa, Protein from Saccharomyces cerevisiae S288C)
- Swi/snf complex subunit swi3 (93 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Swi/snf chromatin-remodeling complex subunit swi1 (148 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Unknown protein (5 kDa, Protein from Saccharomyces cerevisiae S288C)
- Transcription regulatory protein snf12 (63 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Transcription regulatory protein snf6 (19 kDa, Protein from Saccharomyces cerevisiae S288C)
- Transcription regulatory protein snf2 (194 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Swi/snf chromatin-remodeling complex subunit snf5 (102 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Unknown protein (1 kDa, Protein from Saccharomyces cerevisiae S288C)
Yeast RNA polymerase III initial transcribing complex
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6cnb
Q-score: 0.355
Han Y, Yan C, Fishbain S, Ivanov I, He Y
Cell Discov (2018) 4 pp. 40-40 [ DOI: doi:10.1038/s41421-018-0044-z Pubmed: 30083386 ]
- Dna-directed rna polymerases i and iii subunit rpac1 (37 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Zinc ion (65 Da, Ligand)
- Dna-directed rna polymerase iii subunit rpc9 (18 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Transcription factor tfiiib component b'',transcription factor tfiiib component b'',transcription factor tfiiib component b'',transcription factor tfiiib component b'',transcription factor tfiiib component b'' (66 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc2 (129 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc6 (36 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (16 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Yeast rna polymerase iii initial transcribing complex (900 kDa, Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerases i, ii, and iii subunit rpabc4 (7 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerases i and iii subunit rpac2 (16 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc4 (46 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc10 (12 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (17 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (8 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc1 (162 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc3 (74 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna (71-mer) (21 kDa, DNA from Saccharomyces cerevisiae S288c)
- Transcription factor iiib 70 kda subunit,tata-box-binding protein,transcription factor iiib 70 kda subunit (82 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc7,dna-directed rna polymerase iii subunit rpc7,dna-directed rna polymerase iii subunit rpc7,dna-directed rna polymerase iii subunit rpc7,dna-directed rna polymerase iii subunit rpc7 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerases i, ii, and iii subunit rpabc1 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc8 (24 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc5 (32 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna (71-mer) (21 kDa, DNA from Saccharomyces cerevisiae S288c)
Yeast RNA polymerase III open complex
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6cnc
Q-score: 0.361
Han Y, Yan C, Fishbain S, Ivanov I, He Y
Cell Discov (2018) 4 pp. 40-40 [ Pubmed: 30083386 DOI: doi:10.1038/s41421-018-0044-z ]
- Dna-directed rna polymerase iii subunit rpc2 (129 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc3 (74 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc9 (18 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc6 (36 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerases i, ii, and iii subunit rpabc4 (7 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Zinc ion (65 Da, Ligand)
- Dna (71-mer) (21 kDa, DNA from Saccharomyces cerevisiae S288c)
- Dna-directed rna polymerases i, ii, and iii subunit rpabc5 (8 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc5 (32 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc4 (46 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerases i and iii subunit rpac1 (37 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerases i and iii subunit rpac2 (16 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc8 (24 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerases i, ii, and iii subunit rpabc2 (17 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc7,dna-directed rna polymerase iii subunit rpc7,dna-directed rna polymerase iii subunit rpc7,dna-directed rna polymerase iii subunit rpc7,dna-directed rna polymerase iii subunit rpc7 (27 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Transcription factor iiib 70 kda subunit,tata-box-binding protein,transcription factor iiib 70 kda subunit (82 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Transcription factor tfiiib component b'',transcription factor tfiiib component b'',transcription factor tfiiib component b'',transcription factor tfiiib component b'',transcription factor tfiiib component b'' (66 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc10 (12 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna (71-mer) (21 kDa, DNA from Saccharomyces cerevisiae S288c)
- Yeast rna polymerase iii open complex (900 kDa, Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerase iii subunit rpc1 (162 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerases i, ii, and iii subunit rpabc3 (16 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna-directed rna polymerases i, ii, and iii subunit rpabc1 (25 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))