Cryo-EM structure of human NCX1 in apo inactivated state
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8sgj
Q-score: 0.499
Xue J, Zeng W, Han Y, John S, Ottolia M, Jiang Y
Nat Commun (2023) 14 pp. 6181-6181 [ DOI: doi:10.1038/s41467-023-41885-4 Pubmed: 37794011 ]
- Human cardiac ncx1 in complex with antibody fab fragment (Complex)
- Human cardiac ncx1 in apo inactivated state (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Fab light chain (21 kDa, Protein from Mus musculus)
- Sodium/calcium exchanger 1 (109 kDa, Protein from Homo sapiens)
- Antibody fab fragment (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Fab heavy chain (26 kDa, Protein from Mus musculus)
Xue J, Zeng W, Han Y, John S, Ottolia M, Jiang Y
Nat Commun (2023) 14 pp. 6181-6181 [ DOI: doi:10.1038/s41467-023-41885-4 Pubmed: 37794011 ]
- Human cardiac sodium calcium exchanger ncx1 in apo, inactivated state ( group i in the presence of 0.5mm ca2+) (Complex from Homo sapiens)
- Human cardiac sodium calcium exchanger ncx1 (Protein from Homo sapiens)
- Human cardiac sodium calcium exchanger ncx1 in apo, inactivated state ( group i in the presence of 0.5mm ca2+) and bound fab fragment (Complex)
- Antibody fab fragment (Complex from Mus musculus)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8sgt
Q-score: 0.239
Xue J, Zeng W, Han Y, John S, Ottolia M, Jiang Y
Nat Commun (2023) 14 pp. 6181-6181 [ DOI: doi:10.1038/s41467-023-41885-4 Pubmed: 37794011 ]
- Fab light chain (21 kDa, Protein from Mus musculus)
- Sodium/calcium exchanger 1 (109 kDa, Protein from Homo sapiens)
- Antibody fab fragment (Complex from Mus musculus)
- Human ncx1 in ca bound, activated state (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Human ncx1 in complex with antibody fab fragment (Complex)
- Fab heavy chain (26 kDa, Protein from Mus musculus)
Cryo-EM structure of human rod CNGA1/B1 channel in apo state
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 7rh9
Q-score: 0.635
Neuron (2022) 110 pp. 86-95.e5 [ Pubmed: 34699778 DOI: doi:10.1016/j.neuron.2021.10.006 ]
Cryo-EM structure of human rod CNGA1/B1 channel in cAMP-bound state
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 7rhg
Q-score: 0.602
Neuron (2022) 110 pp. 86-95.e5 [ Pubmed: 34699778 DOI: doi:10.1016/j.neuron.2021.10.006 ]
- Cgmp-gated cation channel alpha-1 (64 kDa, Protein from Homo sapiens)
- Adenosine-3',5'-cyclic-monophosphate (329 Da, Ligand)
- Human rod cnga1/b1 channel in camp-bound state (Complex from Homo sapiens)
- Cyclic nucleotide-gated cation channel beta-1 (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openI state
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 7rhh
Q-score: 0.51
Neuron (2022) 110 pp. 86-95.e5 [ Pubmed: 34699778 DOI: doi:10.1016/j.neuron.2021.10.006 ]
- Cgmp-gated cation channel alpha-1 (64 kDa, Protein from Homo sapiens)
- Human rod cnga1/b1 channel in cgmp-bound openi state (Complex from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Cyclic nucleotide-gated cation channel beta-1 (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openII state
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 7rhi
Q-score: 0.49
Neuron (2022) 110 pp. 86-95.e5 [ Pubmed: 34699778 DOI: doi:10.1016/j.neuron.2021.10.006 ]
- Cgmp-gated cation channel alpha-1 (64 kDa, Protein from Homo sapiens)
- Human rod cnga1/b1 channel in cgmp-bound openii state (Complex from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Cyclic nucleotide-gated cation channel beta-1 (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-blocked open state
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 7rhj
Q-score: 0.535
Neuron (2022) 110 pp. 86-95.e5 [ Pubmed: 34699778 DOI: doi:10.1016/j.neuron.2021.10.006 ]
- Human rod cnga1/b1 channel in l-cis-diltiazem-blocked open state (Complex from Homo sapiens)
- (2r,3r)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate (414 Da, Ligand)
- Cyclic nucleotide-gated cation channel beta-1 (91 kDa, Protein from Homo sapiens)
- Cgmp-gated cation channel alpha-1 (64 kDa, Protein from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-trapped closed state
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 7rhk
Q-score: 0.519
Neuron (2022) 110 pp. 86-95.e5 [ Pubmed: 34699778 DOI: doi:10.1016/j.neuron.2021.10.006 ]
- (2r,3r)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate (414 Da, Ligand)
- Cyclic nucleotide-gated cation channel beta-1 (91 kDa, Protein from Homo sapiens)
- Human rod cnga1/b1 channel in l-cis-diltiazem-trapped closed state (Complex from Homo sapiens)
- Cgmp-gated cation channel alpha-1 (64 kDa, Protein from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
Cryo-EM structure of human rod Apo CNGA1/B1 channel with CLZ coiled coil
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 7rhl
Q-score: 0.568
Neuron (2022) 110 pp. 86-95.e5 [ DOI: doi:10.1016/j.neuron.2021.10.006 Pubmed: 34699778 ]