Human Retriever VPS35L/VPS29/VPS26C complex bound to SNX17 peptide (Composite Map)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9au7
Q-score: 0.202
Singla A, Boesch DJ, Fung HYJ, Ngoka C, Enriquez AS, Song R, Kramer DA, Han Y, Banarer E, Lemoff A, Juneja P, Billadeau DD, Bai X, Chen Z, Turer EE, Burstein E, Chen B
Nat Commun (2024) 15 pp. 10193-10193 [ DOI: doi:10.1038/s41467-024-54583-6 Pubmed: 39587083 ]
- Sorting nexin-17 (2 kDa, Protein from Homo sapiens)
- Vacuolar protein sorting-associated protein 26c (33 kDa, Protein from Homo sapiens)
- Trimeric complex of vps35/vps29/vps26 with excess snx17 peptide (Complex from Homo sapiens)
- Vacuolar protein sorting-associated protein 29 (23 kDa, Protein from Homo sapiens)
- Vps35 endosomal protein-sorting factor-like (109 kDa, Protein from Homo sapiens)
Connexin-32 gap junction channel in complex with 2-aminoethoxydiphenyl borate
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8qjf
Q-score: 0.552
Lavriha P, Han Y, Ding X, Schuster D, Qi C, Vaithia A, Picotti P, Korkhov VM
PLoS One (2024) 19 pp. e0315510-e0315510 [ Pubmed: 39739741 DOI: doi:10.1371/journal.pone.0315510 ]
Connexin-32 gap junction channel in complex with mefloquine
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 8qjh
Q-score: 0.524
Lavriha P, Han Y, Ding X, Schuster D, Qi C, Vaithia A, Picotti P, Korkhov VM
PLoS One (2024) 19 pp. e0315510-e0315510 [ Pubmed: 39739741 DOI: doi:10.1371/journal.pone.0315510 ]
Connexin-32 hemichannel upon addition of 2-aminoetoxydiphenyl borate
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8qk6
Q-score: 0.526
Lavriha P, Han Y, Ding X, Schuster D, Qi C, Vaithia A, Picotti P, Korkhov VM
PLoS One (2024) 19 pp. e0315510-e0315510 [ Pubmed: 39739741 DOI: doi:10.1371/journal.pone.0315510 ]
Connexin-32 hemichannel upon addition of mefloquine
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8qki
Q-score: 0.428
Lavriha P, Han Y, Ding X, Schuster D, Qi C, Vaithia A, Picotti P, Korkhov VM
PLoS One (2024) 19 pp. e0315510-e0315510 [ Pubmed: 39739741 DOI: doi:10.1371/journal.pone.0315510 ]
Connexin-43 gap junction channel in complex with mefloquine
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 8qko
Q-score: 0.313
Lavriha P, Han Y, Ding X, Schuster D, Qi C, Vaithia A, Picotti P, Korkhov VM
PLoS One (2024) 19 pp. e0315510-e0315510 [ Pubmed: 39739741 DOI: doi:10.1371/journal.pone.0315510 ]
Plasmodium falciparum 20S proteasome bound to an inhibitor
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8w2f
Q-score: 0.576
Lawong A, Gahalawat S, Ray S, Ho N, Han Y, Ward KE, Deng X, Chen Z, Kumar A, Xing C, Hosangadi V, Fairhurst KJ, Tashiro K, Liszczak G, Shackleford DM, Katneni K, Chen G, Saunders J, Crighton E, Casas A, Robinson JJ, Imlay LS, Zhang X, Lemoff A, Zhao Z, Angulo-Barturen I, Jimenez-Diaz MB, Wittlin S, Campbell SF, Fidock DA, Laleu B, Charman SA, Ready JM, Phillips MA
Cell Chem Biol (2024) 31 pp. 1503- [ DOI: doi:10.1016/j.chembiol.2024.07.001 Pubmed: 39084225 ]
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (33 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome endopeptidase complex (26 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (27 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (24 kDa, Protein from Plasmodium falciparum 3D7)
- (3s)-1-[(2-fluoroethoxy)acetyl]-n-{[(4p)-4-(6-methylpyridin-3-yl)-1,3-thiazol-2-yl]methyl}piperidine-3-carboxamide (420 Da, Ligand)
- Proteasome subunit alpha type (28 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (25 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta (22 kDa, Protein from Plasmodium falciparum 3D7)
- Plasmodium falciparum 20s proteasome bound with an inhibitor (750 kDa, Complex from Plasmodium falciparum 3D7)
- Proteasome endopeptidase complex (29 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit alpha type-3, putative (29 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit alpha type (27 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome endopeptidase complex (28 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta type-6, putative (29 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome subunit beta type (23 kDa, Protein from Plasmodium falciparum 3D7)
CryoEM structure of activated CRAF/MEK/14-3-3 complex with NST-628
Resolution: 4.36 Å
EM Method: Single-particle
Fitted PDBs: 9axa
Q-score: 0.277
Ryan MB, Quade B, Schenk N, Fang Z, Zingg M, Cohen SE, Swalm BM, Li C, Ozen A, Ye C, Ritorto MS, Huang X, Dar AC, Han Y, Hoeflich KP, Hale M, Hagel M
Cancer Discov (2024) 14 pp. 1190-1205 [ Pubmed: 38588399 DOI: doi:10.1158/2159-8290.CD-24-0139 ]
- Gst26/craf chimera (64 kDa, Protein from Homo sapiens)
- Craf/mek/14-3-3 complex with nst-628 (Complex from Homo sapiens)
- 14-3-3 protein sigma (27 kDa, Protein from Homo sapiens)
- N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2h-1-benzopyran-3-yl}methyl)pyridin-2-yl]-n'-methylsulfuric diamide (488 Da, Ligand)
- Dual specificity mitogen-activated protein kinase kinase 1 (43 kDa, Protein from Homo sapiens)
Activated CRAF/MEK heterotetramer from focused refinement of CRAF/MEK/14-3-3 complex
Resolution: 4.16 Å
EM Method: Single-particle
Fitted PDBs: 9axc
Q-score: 0.335
Ryan MB, Quade B, Schenk N, Fang Z, Zingg M, Cohen SE, Swalm BM, Li C, Ozen A, Ye C, Ritorto MS, Huang X, Dar AC, Han Y, Hoeflich KP, Hale M, Hagel M
Cancer Discov (2024) 14 pp. 1190-1205 [ Pubmed: 38588399 DOI: doi:10.1158/2159-8290.CD-24-0139 ]
- Dual specificity mitogen-activated protein kinase kinase 1 (43 kDa, Protein from Homo sapiens)
- Activated craf/mek1 heterotetramer complex from focused refinement (Complex from Homo sapiens)
- N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2h-1-benzopyran-3-yl}methyl)pyridin-2-yl]-n'-methylsulfuric diamide (488 Da, Ligand)
- Gst26/craf chimera (64 kDa, Protein from Homo sapiens)
TFIIIA-TFIIIC-Brf1-TBP complex bound to 5S rRNA gene
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8ffz
Q-score: 0.333
Talyzina A, Han Y, Banerjee C, Fishbain S, Reyes A, Vafabakhsh R, He Y
Mol Cell (2023) 83 pp. 2641- [ DOI: doi:10.1016/j.molcel.2023.06.015 Pubmed: 37402369 ]
- Dna (151-mer) (52 kDa, DNA from Saccharomyces cerevisiae)
- Zinc ion (65 Da, Ligand)
- Dna (151-mer) (52 kDa, DNA from Saccharomyces cerevisiae)
- Transcription factor tau 91 kda subunit (74 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor tau 60 kda subunit (67 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor iiia (52 kDa, Protein from Saccharomyces cerevisiae)
- Tfiiia-tfiiic-brf1-tbp complex bound to 5srrna gene (810 MDa, Complex from Saccharomyces cerevisiae)
- Transcription factor iiib 70 kda subunit,tata-box-binding protein (82 kDa, Protein from Saccharomyces cerevisiae S288C)
- Transcription factor tau 131 kda subunit (120 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor tau 95 kda subunit (73 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor tau 55 kda subunit (49 kDa, Protein from Saccharomyces cerevisiae)
- Transcription factor tau 138 kda subunit (132 kDa, Protein from Saccharomyces cerevisiae)