Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8sgt
Q-score: 0.239
Xue J, Zeng W, Han Y, John S, Ottolia M, Jiang Y
Nat Commun (2023) 14 pp. 6181-6181 [ Pubmed: 37794011 DOI: doi:10.1038/s41467-023-41885-4 ]
- Human ncx1 in complex with antibody fab fragment (Complex)
- Sodium/calcium exchanger 1 (109 kDa, Protein from Homo sapiens)
- Fab light chain (21 kDa, Protein from Mus musculus)
- Human ncx1 in ca bound, activated state (Complex from Homo sapiens)
- Fab heavy chain (26 kDa, Protein from Mus musculus)
- Antibody fab fragment (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
Human TMEM175-LAMP1 full-length complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8fy5
Q-score: 0.505
Zhang J, Zeng W, Han Y, Lee WR, Liou J, Jiang Y
Mol Cell (2023) 83 pp. 2524-2539.e7 [ Pubmed: 37390818 DOI: doi:10.1016/j.molcel.2023.06.004 ]
- Lysosome-associated membrane glycoprotein 1 (44 kDa, Protein from Homo sapiens)
- Tmem175-lamp1 full-length (Complex from Homo sapiens)
- Endosomal/lysosomal potassium channel tmem175 (55 kDa, Protein from Homo sapiens)
Human TMEM175-LAMP1 transmembrane domain only complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8fyf
Q-score: 0.499
Cryo-EM structure of mouse agonist ML-SA1-bound TRPML1 channel at 2.32 Angstrom resolution
Resolution: 2.32 Å
EM Method: Single-particle
Fitted PDBs: 7sq6
Q-score: 0.659
Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y
PNAS (2022) 119 [ DOI: doi:10.1073/pnas.2120404119 Pubmed: 35131932 ]
- Water (18 Da, Ligand)
- Mucolipin-1 (65 kDa, Protein from Mus musculus)
- Mouse transient receptor potential-mucolipin 1 apo closed state (Complex from Mus musculus)
- Sodium ion (22 Da, Ligand)
- 2-{2-oxo-2-[(4s)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2h)-yl]ethyl}-1h-isoindole-1,3(2h)-dione (362 Da, Ligand)
Cryo-EM structure of mouse PI(3,5)P2-bound TRPML1 channel at 2.41 Angstrom resolution
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 7sq7
Q-score: 0.627
Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y
PNAS (2022) 119 [ DOI: doi:10.1073/pnas.2120404119 Pubmed: 35131932 ]
- Water (18 Da, Ligand)
- (2r)-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (746 Da, Ligand)
- Mucolipin-1 (65 kDa, Protein from Mus musculus)
- Mouse transient receptor potential-mucolipin 1 apo closed state (Complex from Mus musculus)
- Sodium ion (22 Da, Ligand)
Cryo-EM structure of mouse apo TRPML1 channel at 2.598 Angstrom resolution
Resolution: 2.598 Å
EM Method: Single-particle
Fitted PDBs: 7sq8
Q-score: 0.618
Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y
PNAS (2022) 119 [ DOI: doi:10.1073/pnas.2120404119 Pubmed: 35131932 ]
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Mucolipin-1 (65 kDa, Protein from Mus musculus)
- Mouse transient receptor potential-mucolipin 1 apo closed state (Complex from Mus musculus)
Cryo-EM structure of mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution
Resolution: 2.11 Å
EM Method: Single-particle
Fitted PDBs: 7sq9
Q-score: 0.69
Gan N, Han Y, Zeng W, Wang Y, Xue J, Jiang Y
PNAS (2022) 119 [ DOI: doi:10.1073/pnas.2120404119 Pubmed: 35131932 ]
- (2r)-3-{[(s)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate (746 Da, Ligand)
- Water (18 Da, Ligand)
- Mucolipin-1 (65 kDa, Protein from Mus musculus)
- Mouse transient receptor potential-mucolipin 1 apo closed state (Complex from Mus musculus)
- (1r,2r,4s)-4-{(2r)-2-[(3s,6r,7e,9r,10r,12r,14s,15e,17e,19e,21s,23s,26r,27r,30s,34as)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3h-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate (1 kDa, Ligand)
- Sodium ion (22 Da, Ligand)
Cryo-EM structure of human TMEM120A
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7n7p
Q-score: 0.508
Xue J, Han Y, Baniasadi H, Zeng W, Pei J, Grishin NV, Wang J, Tu BP, Jiang Y
eLife (2021) 10 [ Pubmed: 34374645 DOI: doi:10.7554/eLife.71220 ]
- Ion channel tacan (42 kDa, Protein from Homo sapiens)
- Human tmem120a with coa (Complex from Homo sapiens)
- Coenzyme a (767 Da, Ligand)
MCU holocomplex in High-calcium state
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 6xjv
Q-score: 0.31
Wang Y, Han Y, She J, Nguyen NX, Mootha VK, Bai XC, Jiang Y
eLife (2020) 9 [ DOI: doi:10.7554/eLife.60513 Pubmed: 32762847 ]
- Mcu/emre/micu1/micu2 complex (529 kDa, Complex from Homo sapiens)
- Calcium uptake protein 1, mitochondrial (54 kDa, Protein from Homo sapiens)
- Essential mcu regulator, mitochondrial (11 kDa, Protein from Homo sapiens)
- Calcium uniporter protein, mitochondrial (39 kDa, Protein from Homo sapiens)
- Calcium uptake protein 2, mitochondrial (49 kDa, Protein from Homo sapiens)
MCU holocomplex in Low-calcium blocking state
Resolution: 4.6 Å
EM Method: Single-particle
Fitted PDBs: 6xjx
Q-score: 0.308
Wang Y, Han Y, She J, Nguyen NX, Mootha VK, Bai XC, Jiang Y
eLife (2020) 9 [ DOI: doi:10.7554/eLife.60513 Pubmed: 32762847 ]
- Mcu/emre/micu1/micu2 complex (529 kDa, Complex from Homo sapiens)
- Calcium uptake protein 1, mitochondrial (54 kDa, Protein from Homo sapiens)
- Essential mcu regulator, mitochondrial (11 kDa, Protein from Homo sapiens)
- Calcium uniporter protein, mitochondrial (39 kDa, Protein from Homo sapiens)
- Calcium uptake protein 2, mitochondrial (49 kDa, Protein from Homo sapiens)