The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators.
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6muv
Q-score: 0.397
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ Pubmed: 31384003 DOI: doi:10.1038/s41564-019-0524-4 ]
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- Proteasome activator pa28 (33 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 11s activator of the plasmodium falciparum proteasome. (Complex from Plasmodium falciparum 3D7)
- Plasmodium falciparum 20s proteasome (Complex from Plasmodium falciparum 3D7)
- 20s proteasome/pa28 complex. (230 kDa, Complex from Plasmodium falciparum 3D7)
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
The structure of the Plasmodium falciparum 20S proteasome.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6muw
Q-score: 0.461
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ Pubmed: 31384003 DOI: doi:10.1038/s41564-019-0524-4 ]
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome/pa28 complex. (760 kDa, Complex from Plasmodium falciparum 3D7)
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator.
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6mux
Q-score: 0.439
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ Pubmed: 31384003 DOI: doi:10.1038/s41564-019-0524-4 ]
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome activator pa28 (33 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum 3D7)
- 11s activator of the plasmodium falciparum proteasome. (Complex from Plasmodium falciparum 3D7)
- Plasmodium falciparum 20s proteasome (Complex from Plasmodium falciparum 3D7)
- 20s proteasome/pa28 complex. (230 kDa, Complex from Plasmodium falciparum 3D7)
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ Pubmed: 31384003 DOI: doi:10.1038/s41564-019-0524-4 ]
Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 5umd
Q-score: 0.46
Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SH, Baum J
Nat Microbiol (2017) 2 pp. 17031-17031 [ DOI: doi:10.1038/nmicrobiol.2017.31 Pubmed: 28288098 ]
- 60s ribosomal protein l21 (18 kDa, Protein from Plasmodium falciparum 3D7)
- Ribosomal protein l15 (24 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l6-2, putative (25 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l39 (6 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l7, putative (30 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l7-3, putative (32 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l24, putative (19 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l22, putative (16 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l44 (12 kDa, Protein from Plasmodium falciparum 3D7)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l14, putative (19 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l31 (14 kDa, Protein from Plasmodium falciparum 3D7)
- 5.8s ribosomal rna (51 kDa, RNA from Plasmodium falciparum 3D7)
- 60s ribosomal protein l38 (10 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l2 (28 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l18a (21 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l29, putative (8 kDa, Protein from Plasmodium falciparum 3D7)
- 28s ribosomal rna (1 MDa, RNA from Plasmodium falciparum 3D7)
- 60s ribosomal protein l27 (16 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l6, putative (21 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l13 (25 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l36 (12 kDa, Protein from Plasmodium falciparum 3D7)
- 5s ribosomal rna (38 kDa, RNA from Plasmodium falciparum 3D7)
- 60s ribosomal protein l4 (46 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l11a, putative (20 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l19 (21 kDa, Protein from Plasmodium falciparum 3D7)
- Ribosomal protein l37 (10 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l23 (22 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l30e, putative (11 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l32 (15 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l35ae, putative (16 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l34 (17 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l35, putative (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l17, putative (23 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l28 (14 kDa, Protein from Plasmodium falciparum 3D7)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l27a, putative (16 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l37a (10 kDa, Protein from Plasmodium falciparum 3D7)
- (11r,12s)- mefloquine (378 Da, Ligand)
- 60s ribosomal protein l13, putative (23 kDa, Protein from Plasmodium falciparum 3D7)
- Plasmodium falciparum 80s ribosome bound to mefloquine (4 MDa, Complex from Plasmodium falciparum 3D7)
- 60s ribosomal protein l23, putative (15 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l41 (5 kDa, Protein from Plasmodium falciparum 3D7)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l26, putative (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l5, putative (34 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l3 (44 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l10, putative (25 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l18-2, putative (21 kDa, Protein from Plasmodium falciparum 3D7)
Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 3j79, 3j7a
Q-score: 0.322
Wong W, Bai XC, Brown A, Fernandez IS, Hanssen E, Condron M, Tan YH, Baum J, Scheres SHW
eLife (2014) 3 pp. e03080- [ Pubmed: 24913268 DOI: doi:10.7554/eLife.03080 ]
Cryo-EM structure of the Plasmodium falciparum 80S ribosome
Wong W, Bai XC, Brown A, Fernandez IS, Hanssen E, Condron M, Tan YH, Baum J, Scheres SHW
eLife (2014) 3 pp. e03080- [ Pubmed: 24913268 DOI: doi:10.7554/eLife.03080 ]
- Plasmodium falciparum 80s ribosome (4 MDa, Sample)
- Plasmodium falciparum 80s ribosome (4 MDa, Complex from Plasmodium falciparum)