The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators.
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6muv
Q-score: 0.397
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ DOI: doi:10.1038/s41564-019-0524-4 Pubmed: 31384003 ]
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 11s activator of the plasmodium falciparum proteasome. (Complex from Plasmodium falciparum 3D7)
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- Plasmodium falciparum 20s proteasome (Complex from Plasmodium falciparum 3D7)
- 20s proteasome/pa28 complex. (230 kDa, Complex from Plasmodium falciparum 3D7)
- Proteasome activator pa28 (33 kDa, Protein from Plasmodium falciparum (isolate 3D7))
The structure of the Plasmodium falciparum 20S proteasome.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6muw
Q-score: 0.461
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ DOI: doi:10.1038/s41564-019-0524-4 Pubmed: 31384003 ]
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome/pa28 complex. (760 kDa, Complex from Plasmodium falciparum 3D7)
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator.
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6mux
Q-score: 0.439
Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L
Nat Microbiol (2019) 4 pp. 1990-2000 [ DOI: doi:10.1038/s41564-019-0524-4 Pubmed: 31384003 ]
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum 3D7)
- 11s activator of the plasmodium falciparum proteasome. (Complex from Plasmodium falciparum 3D7)
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome/pa28 complex. (230 kDa, Complex from Plasmodium falciparum 3D7)
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum 3D7)
- Proteasome activator pa28 (33 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum 3D7)
- Plasmodium falciparum 20s proteasome (Complex from Plasmodium falciparum 3D7)
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum 3D7)
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum 3D7)
Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 5umd
Q-score: 0.46
Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SH, Baum J
Nat Microbiol (2017) 2 pp. 17031-17031 [ Pubmed: 28288098 DOI: doi:10.1038/nmicrobiol.2017.31 ]
- 60s ribosomal protein l14, putative (19 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l34 (17 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l4 (46 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l41 (5 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l23 (22 kDa, Protein from Plasmodium falciparum 3D7)
- 28s ribosomal rna (1 MDa, RNA from Plasmodium falciparum 3D7)
- 60s ribosomal protein l6, putative (21 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l3 (44 kDa, Protein from Plasmodium falciparum 3D7)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l35, putative (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l29, putative (8 kDa, Protein from Plasmodium falciparum 3D7)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Plasmodium falciparum 3D7)
- Ribosomal protein l15 (24 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l27a, putative (16 kDa, Protein from Plasmodium falciparum 3D7)
- Plasmodium falciparum 80s ribosome bound to mefloquine (4 MDa, Complex from Plasmodium falciparum 3D7)
- 60s ribosomal protein l6-2, putative (25 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l18-2, putative (21 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l13 (25 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l21 (18 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l7, putative (30 kDa, Protein from Plasmodium falciparum 3D7)
- (11r,12s)- mefloquine (378 Da, Ligand)
- 60s ribosomal protein l17, putative (23 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l44 (12 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l19 (21 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l35ae, putative (16 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l11a, putative (20 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l18a (21 kDa, Protein from Plasmodium falciparum 3D7)
- 5s ribosomal rna (38 kDa, RNA from Plasmodium falciparum 3D7)
- 5.8s ribosomal rna (51 kDa, RNA from Plasmodium falciparum 3D7)
- Ribosomal protein l37 (10 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l38 (10 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l32 (15 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l27 (16 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l5, putative (34 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l10, putative (25 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l24, putative (19 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l23, putative (15 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l28 (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l39 (6 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l37a (10 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l7-3, putative (32 kDa, Protein from Plasmodium falciparum 3D7)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l36 (12 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l30e, putative (11 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l2 (28 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l26, putative (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l13, putative (23 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l31 (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l22, putative (16 kDa, Protein from Plasmodium falciparum 3D7)