Structure of Plasmodium falciparum 20S proteasome with bound bortezomib.
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7lxt
Q-score: 0.498
Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, Deni I, Yeo T, Ward KE, Barry DC, Liu B, Gillett DL, Crespo-Fernandez BF, Ottilie S, Mittal N, Churchyard A, Ferguson D, Aguiar ACC, Guido RVC, Baum J, Hanson KK, Winzeler EA, Gamo FJ, Fidock DA, Baud D, Parker MW, Brand S, Dick LR, Griffin MDW, Gould AE, Tilley L
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2107213118 Pubmed: 34548400 ]
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- N-[(1r)-1-(dihydroxyboryl)-3-methylbutyl]-n-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide (384 Da, Ligand)
- Plasmodium falciparum 20s proteasome complexed with bortezomib (700 kDa, Complex from Plasmodium falciparum 3D7)
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum)
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
Structure of Plasmodium falciparum 20S proteasome with bound ML052.
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7lxu
Q-score: 0.524
Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, Deni I, Yeo T, Ward KE, Barry DC, Liu B, Gillett DL, Crespo-Fernandez BF, Ottilie S, Mittal N, Churchyard A, Ferguson D, Aguiar ACC, Guido RVC, Baum J, Hanson KK, Winzeler EA, Gamo FJ, Fidock DA, Baud D, Parker MW, Brand S, Dick LR, Griffin MDW, Gould AE, Tilley L
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2107213118 Pubmed: 34548400 ]
- 20s proteasome beta-5 subunit (23 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- N-[(1r)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-l-prolinamide (352 Da, Ligand)
- 20s proteasome alpha-2 subunit (26 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-7 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-3 subunit (24 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-2 subunit (25 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-3 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-4 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-7 subunit (30 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-4 subunit (22 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-1 subunit (29 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- Plasmodium falciparum 20s proteasome complexed with ml052 (700 kDa, Complex from Plasmodium falciparum)
- 20s proteasome alpha-5 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome beta-6 subunit (27 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- 20s proteasome alpha-6 subunit (28 kDa, Protein from Plasmodium falciparum (isolate 3D7))
Structure of human 20S proteasome with bound ML052.
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7lxv
Q-score: 0.496
Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, Deni I, Yeo T, Ward KE, Barry DC, Liu B, Gillett DL, Crespo-Fernandez BF, Ottilie S, Mittal N, Churchyard A, Ferguson D, Aguiar ACC, Guido RVC, Baum J, Hanson KK, Winzeler EA, Gamo FJ, Fidock DA, Baud D, Parker MW, Brand S, Dick LR, Griffin MDW, Gould AE, Tilley L
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2107213118 Pubmed: 34548400 ]
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- N-[(1r)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-l-prolinamide (352 Da, Ligand)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-5 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (21 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (25 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (23 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (24 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Homo sapiens 20s proteasome complexed with ml052 (700 kDa, Complex from Plasmodium falciparum 3D7)
Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 5umd
Q-score: 0.46
Wong W, Bai XC, Sleebs BE, Triglia T, Brown A, Thompson JK, Jackson KE, Hanssen E, Marapana DS, Fernandez IS, Ralph SA, Cowman AF, Scheres SH, Baum J
Nat Microbiol (2017) 2 pp. 17031-17031 [ Pubmed: 28288098 DOI: doi:10.1038/nmicrobiol.2017.31 ]
- 60s ribosomal protein l14, putative (19 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l34 (17 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l4 (46 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l41 (5 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l23 (22 kDa, Protein from Plasmodium falciparum 3D7)
- 28s ribosomal rna (1 MDa, RNA from Plasmodium falciparum 3D7)
- 60s ribosomal protein l6, putative (21 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l3 (44 kDa, Protein from Plasmodium falciparum 3D7)
- Zinc ion (65 Da, Ligand)
- 60s ribosomal protein l35, putative (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l29, putative (8 kDa, Protein from Plasmodium falciparum 3D7)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Plasmodium falciparum 3D7)
- Ribosomal protein l15 (24 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l27a, putative (16 kDa, Protein from Plasmodium falciparum 3D7)
- Plasmodium falciparum 80s ribosome bound to mefloquine (4 MDa, Complex from Plasmodium falciparum 3D7)
- 60s ribosomal protein l6-2, putative (25 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l18-2, putative (21 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l13 (25 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l21 (18 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l7, putative (30 kDa, Protein from Plasmodium falciparum 3D7)
- (11r,12s)- mefloquine (378 Da, Ligand)
- 60s ribosomal protein l17, putative (23 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l44 (12 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l19 (21 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l35ae, putative (16 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l11a, putative (20 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l18a (21 kDa, Protein from Plasmodium falciparum 3D7)
- 5s ribosomal rna (38 kDa, RNA from Plasmodium falciparum 3D7)
- 5.8s ribosomal rna (51 kDa, RNA from Plasmodium falciparum 3D7)
- Ribosomal protein l37 (10 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l38 (10 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l32 (15 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l27 (16 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l5, putative (34 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l10, putative (25 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l24, putative (19 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l23, putative (15 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l28 (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l39 (6 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l37a (10 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l7-3, putative (32 kDa, Protein from Plasmodium falciparum 3D7)
- Magnesium ion (24 Da, Ligand)
- 60s ribosomal protein l36 (12 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l30e, putative (11 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l2 (28 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l26, putative (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l13, putative (23 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l31 (14 kDa, Protein from Plasmodium falciparum 3D7)
- 60s ribosomal protein l22, putative (16 kDa, Protein from Plasmodium falciparum 3D7)