Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 7nzm
Q-score: 0.26
Nat Struct Mol Biol (2021) 28 pp. 835-846 [ Pubmed: 34625748 DOI: doi:10.1038/s41594-021-00666-7 ]
- Protein phosphatase 1 regulatory subunit 15a,maltose/maltodextrin-binding periplasmic protein (49 kDa, Protein from Escherichia coli (strain K12))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Actin, alpha skeletal muscle, intermediate form (41 kDa, Protein from Oryctolagus cuniculus)
- Manganese (ii) ion (54 Da, Ligand)
- Deoxyribonuclease-1 (29 kDa, Protein from Bos taurus)
- Serine/threonine-protein phosphatase pp1-alpha catalytic subunit (33 kDa, Protein from Oryctolagus cuniculus)
- Pre-dephosphorylation complex of phosphorylated eif2alpha_2-187 with trapped holophosphatase (pp1a_d64a/ppp1r15a_553-624/g-actin) (181 kDa, Complex)
- Eukaryotic translation initiation factor 2 subunit 1 (21 kDa, Protein from Homo sapiens)
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7d43
Q-score: 0.385
Zyryanova AF, Kashiwagi K, Rato C, Harding HP, Crespillo-Casado A, Perera LA, Sakamoto A, Nishimoto M, Yonemochi M, Shirouzu M, Ito T, Ron D
Mol Cell (2021) 81 pp. 88- [ Pubmed: 33220178 DOI: doi:10.1016/j.molcel.2020.10.031 ]
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit alpha (33 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Complex of eif2b with eif2(ap) (Complex)
- Eukaryotic translation initiation factor 2 subunit 2 (38 kDa, Protein from Homo sapiens)
- Eif2(ap) (Complex from Homo sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 1 (36 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 3 (51 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit beta (39 kDa, Protein from Homo sapiens)
- Eif2b (Complex from Homo sapiens)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7d44
Q-score: 0.421
Zyryanova AF, Kashiwagi K, Rato C, Harding HP, Crespillo-Casado A, Perera LA, Sakamoto A, Nishimoto M, Yonemochi M, Shirouzu M, Ito T, Ron D
Mol Cell (2021) 81 pp. 88- [ Pubmed: 33220178 DOI: doi:10.1016/j.molcel.2020.10.031 ]
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit alpha (33 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Complex of eif2b with eif2(ap) (Complex)
- Eif2(ap) (Complex from Homo sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 1 (36 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit beta (39 kDa, Protein from Homo sapiens)
- Eif2b (Complex from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7d45
Q-score: 0.462
Zyryanova AF, Kashiwagi K, Rato C, Harding HP, Crespillo-Casado A, Perera LA, Sakamoto A, Nishimoto M, Yonemochi M, Shirouzu M, Ito T, Ron D
Mol Cell (2021) 81 pp. 88- [ Pubmed: 33220178 DOI: doi:10.1016/j.molcel.2020.10.031 ]
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit alpha (33 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Complex of eif2b with eif2(ap) (Complex)
- Eif2(ap) (Complex from Homo sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor 2 subunit 1 (36 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit beta (39 kDa, Protein from Homo sapiens)
- Eif2b (Complex from Homo sapiens)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7d46
Q-score: 0.461
Zyryanova AF, Kashiwagi K, Rato C, Harding HP, Crespillo-Casado A, Perera LA, Sakamoto A, Nishimoto M, Yonemochi M, Shirouzu M, Ito T, Ron D
Mol Cell (2021) 81 pp. 88- [ Pubmed: 33220178 DOI: doi:10.1016/j.molcel.2020.10.031 ]
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit alpha (33 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit epsilon (80 kDa, Protein from Homo sapiens)
- Complex of eif2b with eif2(ap) (Complex from Homo sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit beta (39 kDa, Protein from Homo sapiens)
Eukaryotic initiation factor EIF2B in complex with ISRIB
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6ezo
Q-score: 0.436
Zyryanova AF, Weis F, Faille A, Alard AA, Crespillo-Casado A, Sekine Y, Harding HP, Allen F, Parts L, Fromont C, Fischer PM, Warren AJ, Ron D
Science (2018) 359 pp. 1533-1536 [ DOI: doi:10.1126/science.aar5129 Pubmed: 29599245 ]
- Translation initiation factor eif-2b subunit gamma (50 kDa, Protein from Homo sapiens)
- Translation initiation factor eif-2b subunit alpha (33 kDa, Protein from Homo sapiens)
- Eukaryotic translation initiation factor eif2b (Complex from Homo sapiens)
- Human eukaryotic initiation factor eif2b epsilon subunits (80 kDa, Protein from Homo Sapiens)
- Translation initiation factor eif-2b subunit delta (57 kDa, Protein from Homo sapiens)
- Isrib (Complex from Homo sapiens)
- 2-(4-chloranylphenoxy)-~{n}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide (451 Da, Ligand)
- Translation initiation factor eif-2b subunit beta (41 kDa, Protein from Homo sapiens)
- Eukaryotic initiation factor eif2b in complex with isrib (521 kDa, Complex)