DNA-PK Ku80 mediated dimer bound to PAXX
Resolution: 4.55 Å
EM Method: Single-particle
Fitted PDBs: 8bh3
Q-score: 0.185
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, Chaplin AK
Sci Adv (2023) 9 pp. eadg2834-eadg2834 [ DOI: doi:10.1126/sciadv.adg2834 Pubmed: 37256950 ]
- Dna (26-mer) (8 kDa, DNA from Homo sapiens)
- Dna (25-mer) (7 kDa, DNA from Homo sapiens)
- Nhej supercomplex bound to paxx (1 MDa, Complex from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Dna ligase 4 (104 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- Protein paxx (21 kDa, Protein from Homo sapiens)
- Dna (28-mer) (8 kDa, DNA from Homo sapiens)
- Dna repair protein xrcc4 (38 kDa, Protein from Homo sapiens)
- Dna (27-mer) (8 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
DNA-PK XLF mediated dimer bound to PAXX
Resolution: 4.51 Å
EM Method: Single-particle
Fitted PDBs: 8bhv
Q-score: 0.203
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, Chaplin AK
Sci Adv (2023) 9 pp. eadg2834-eadg2834 [ DOI: doi:10.1126/sciadv.adg2834 Pubmed: 37256950 ]
- Dna (28-mer) (7 kDa, DNA from Homo sapiens)
- Dna (27-mer) (8 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Non-homologous end-joining factor 1 (33 kDa, Protein from Homo sapiens)
- Dna (26-mer) (8 kDa, DNA from Homo sapiens)
- Dna ligase 4 (104 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- Protein paxx (21 kDa, Protein from Homo sapiens)
- Dna-pk xlf mediated dimer bound to paxx (1 MDa, Complex from Homo sapiens)
- Dna repair protein xrcc4 (38 kDa, Protein from Homo sapiens)
- Dna (24-mer) (7 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
DNA-PK Ku80 mediated dimer bound to PAXX and XLF
Resolution: 5.33 Å
EM Method: Single-particle
Fitted PDBs: 8bhy
Q-score: 0.166
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, Chaplin AK
Sci Adv (2023) 9 pp. eadg2834-eadg2834 [ DOI: doi:10.1126/sciadv.adg2834 Pubmed: 37256950 ]
- Dna (25-mer) (7 kDa, DNA from Homo sapiens)
- Dna (5'-d(p*ap*ap*tp*ap*ap*tp*ap*gp*tp*tp*tp*tp*tp*ap*gp*tp*tp*tp*ap*tp*tp*gp*gp*g)-3') (7 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Non-homologous end-joining factor 1 (33 kDa, Protein from Homo sapiens)
- Dna ligase 4 (104 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- Protein paxx (21 kDa, Protein from Homo sapiens)
- Dna-pk ku80 mediated dimer bound to paxx and xlf (1 MDa, Cellular component from Homo sapiens)
- Dna repair protein xrcc4 (38 kDa, Protein from Homo sapiens)
- Dna (26-mer) (7 kDa, DNA from Homo sapiens)
- Dna (27-mer) (8 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
Cryo-EM structure of NHEJ super-complex (dimer)
Resolution: 4.14 Å
EM Method: Single-particle
Fitted PDBs: 7nfc
Q-score: 0.2
Chaplin AK, Hardwick SW, Stavridi AK, Buehl CJ, Goff NJ, Ropars V, Liang S, De Oliveira TM, Chirgadze DY, Meek K, Charbonnier JB, Blundell TL
Mol Cell (2021) 81 pp. 3400-3409 [ DOI: doi:10.1016/j.molcel.2021.07.005 Pubmed: 34352203 ]
- Repair protein and ligase (Cellular component from Homo sapiens)
- Dna (Cellular component from Homo sapiens)
- Dna (28-mer) (8 kDa, DNA from Homo sapiens)
- Dna (27-mer) (8 kDa, DNA from Homo sapiens)
- Dna (27-mer) (8 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Non-homologous end-joining factor 1 (33 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit,dna-dependent protein kinase catalytic subunit,dna-pkcs (471 kDa, Protein from Homo sapiens)
- Dna ligase 4 (104 kDa, Protein from Homo sapiens)
- Nhej super-complex (dimer) (1 MDa, Cellular component)
- X-ray repair cross-complementing proteins 5 and 6 (Cellular component from Homo sapiens)
- Dna repair protein xrcc4 (38 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (Cellular component from Homo sapiens)
Cryo-EM structure of DNA-PK dimer
Resolution: 7.24 Å
EM Method: Single-particle
Fitted PDBs: 6zhe
Q-score: 0.195
Chaplin AK, Hardwick SW, Liang S, Kefala Stavridi A, Hnizda A, Cooper LR, De Oliveira TM, Chirgadze DY, Blundell TL
Nat Struct Mol Biol (2021) 28 pp. 13-19 [ Pubmed: 33077952 DOI: doi:10.1038/s41594-020-00517-x ]
- Dna (26-mer) (8 kDa, DNA from Homo sapiens)
- Dna (Cellular component from Homo sapiens)
- Dna (25-mer) (7 kDa, DNA from Homo sapiens)
- Dna (28-mer) (8 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Dna-pk dimer (1 MDa, Cellular component)
- X-ray repair cross-complementing proteins 5 and 6 (Cellular component from Homo sapiens)
- Dna (27-mer) (8 kDa, DNA from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit,dna-pkcs (472 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (Cellular component from Homo sapiens)
CryoEM structure of human CMG bound to AND-1 (CMGA)
Resolution: 6.77 Å
EM Method: Single-particle
Fitted PDBs: 6xty
Q-score: 0.127
Rzechorzek NJ, Hardwick SW, Jatikusumo VA, Chirgadze DY, Pellegrini L
Nucleic Acids Res (2020) 48 pp. 6980-6995 [ DOI: doi:10.1093/nar/gkaa429 Pubmed: 32453425 ]
- Dna replication complex gins protein psf3 (24 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Wd repeat and hmg-box dna-binding protein 1 (130 kDa, Protein from Homo sapiens)
- Complex of human cmg bound to and1 (Complex from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication complex gins protein sld5 (26 kDa, Protein from Homo sapiens)
- Cell division control protein 45 homolog (65 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm3 (96 kDa, Protein from Homo sapiens)
- Dna replication complex gins protein psf1 (23 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna replication complex gins protein psf2 (21 kDa, Protein from Homo sapiens)
- Human cmg helicase (Complex from Homo sapiens)
- And1 (Complex from Homo sapiens)