Cryo-EM structure of NHEJ super-complex (monomer)
Resolution: 4.29 Å
EM Method: Single-particle
Fitted PDBs: 7nfe
Q-score: 0.203
Chaplin AK, Hardwick SW, Stavridi AK, Buehl CJ, Goff NJ, Ropars V, Liang S, De Oliveira TM, Chirgadze DY, Meek K, Charbonnier JB, Blundell TL
Mol Cell (2021) 81 pp. 3400-3409 [ DOI: doi:10.1016/j.molcel.2021.07.005 Pubmed: 34352203 ]
- X-ray repair cross-complementing protein 6 and 5 (Cellular component from Homo sapiens)
- Dna (Cellular component from Homo sapiens)
- Dna (5'-d(p*ap*ap*tp*ap*ap*ap*cp*tp*ap*ap*ap*ap*ap*cp*tp*ap*tp*tp*ap*tp*tp*ap*tp*g)-3') (7 kDa, DNA from Homo sapiens)
- Nhej super-complex (monomer) (800 kDa, Cellular component)
- Non-homologous end-joining factor 1,dna repair protein xrcc4, dna ligase 4 (Cellular component from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit,dna-dependent protein kinase catalytic subunit,dna-dependent protein kinase catalytic subunit (472 kDa, Protein from Homo sapiens)
- Dna (5'-d(p*tp*ap*ap*tp*ap*ap*tp*ap*gp*tp*tp*tp*tp*tp*ap*gp*tp*tp*tp*ap*tp*tp*ap*g)-3') (7 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Dna repair protein xrcc4 (38 kDa, Protein from Homo sapiens)
- Dna ligase 4 (104 kDa, Protein from Homo sapiens)
- Non-homologous end-joining factor 1 (33 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (Cellular component from Homo sapiens)
Resolution: 1.7 Å
EM Method: Single-particle
Fitted PDBs: 7a5v
Q-score: 0.75
Nakane T, Kotecha A, Sente A, McMullan G, Masiulis S, Brown PMGE, Grigoras IT, Malinauskaite L, Malinauskas T, Miehling J, Uchanski T, Yu L, Karia D, Pechnikova EV, de Jong E, Keizer J, Bischoff M, McCormack J, Tiemeijer P, Hardwick SW, Chirgadze DY, Murshudov G, Aricescu AR, Scheres SHW
Nature (2020) 587 pp. 152-156 [ DOI: doi:10.1038/s41586-020-2829-0 Pubmed: 33087931 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Megabody-25 (Complex from Lama glama)
- Human gaba(a)r-beta3 homopentamer (Complex from Homo sapiens)
- Histamine (111 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3,gamma-aminobutyric acid receptor subunit beta-3 (45 kDa, Protein from Homo sapiens)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Human gaba(a)r-beta3 homopentamer in complex with megabody-25 in lipid nanodisc (485 kDa, Complex)
- Megabody mb25 (56 kDa, Protein from Lama glama)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Cryo-EM structure of DNA-PK monomer
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 6zha
Q-score: 0.338
Chaplin AK, Hardwick SW, Liang S, Kefala Stavridi A, Hnizda A, Cooper LR, De Oliveira TM, Chirgadze DY, Blundell TL
Nat Struct Mol Biol (2021) 28 pp. 13-19 [ Pubmed: 33077952 DOI: doi:10.1038/s41594-020-00517-x ]
- X-ray repair cross-complementing protein 5+6 (Complex from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (Complex from Homo sapiens)
- Dna-pk monomer (640 kDa, Complex)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Dna (7 kDa, DNA from Homo sapiens)
- Dna (7 kDa, DNA from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit,dna-dependent protein kinase catalytic subunit,dna-dependent protein kinase catalytic subunit,dna-pkcs (472 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
CryoEM structure of human CMG bound to ATPgammaS and DNA
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 6xtx
Q-score: 0.506
Rzechorzek NJ, Hardwick SW, Jatikusumo VA, Chirgadze DY, Pellegrini L
Nucleic Acids Res (2020) 48 pp. 6980-6995 [ DOI: doi:10.1093/nar/gkaa429 Pubmed: 32453425 ]
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Dna replication complex gins protein psf1 (23 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Human cmg helicase (Complex from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Dna replication licensing factor mcm4 (99 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna (5'-d(p*tp*tp*tp*tp*tp*tp*tp*tp*tp*tp*t)-3') (21 kDa, DNA from synthetic construct)
- Dna replication complex gins protein psf3 (24 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dna replication complex gins protein psf2 (25 kDa, Protein from Homo sapiens)
- Dna replication complex gins protein sld5 (26 kDa, Protein from Homo sapiens)
- Cell division control protein 45 homolog (65 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm3 (96 kDa, Protein from Homo sapiens)
- Dna (Complex from synthetic construct)
- Complex of human cmg bound to dna (Complex)