GABA-A receptor a5 homomer - a5V3 - APO
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8bej
Q-score: 0.463
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gaba-a a5 homopentamer a5v3 (205 kDa, Complex from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - Basmisanil - HR
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8bha
Q-score: 0.571
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Basmisanil (445 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Gaba-a a5 subunit homopentamer complex called a5v3 (200 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
GABA-A receptor a5 homomer - a5V3 - RO154513
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8bhb
Q-score: 0.587
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Ethyl 8-[(azanylidene-$l^{4}-azanylidene)amino]-5-methyl-6-oxidanylidene-4~{h}-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (326 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Gaba-a a5 homopentamer a5v3 (205 kDa, Complex from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - RO5211223
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8bhi
Q-score: 0.557
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gaba-a receptor a5 homomer - a5v3 - ro5211223 (205 kDa, Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [1,1-bis(oxidanylidene)-1,4-thiazinan-4-yl]-[6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone (442 Da, Ligand)
GABA-A receptor a5 homomer - a5V3 - Diazepam
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8bhk
Q-score: 0.495
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- 7-chloro-1-methyl-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one (284 Da, Ligand)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
GABA-A receptor a5 homomer - a5V3 - DMCM
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8bhm
Q-score: 0.485
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Methyl 4-ethyl-6,7-dimethoxy-9h-pyrido[3,4-b]indole-3-carboxylate (314 Da, Ligand)
GABA-A receptor a5 homomer - a5V3 - L655708
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8bho
Q-score: 0.493
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ethyl (7~{s})-15-methoxy-12-oxidanylidene-2,4,11-triazatetracyclo[11.4.0.0^{2,6}.0^{7,11}]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate (341 Da, Ligand)
GABA-A receptor a5 homomer - a5V3 - RO7172670
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8bhq
Q-score: 0.498
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2-[[5-methyl-3-(6-methylpyridazin-3-yl)-1,2-oxazol-4-yl]methyl]-5-(5-oxa-2-azaspiro[3.5]nonan-2-yl)pyridazin-3-one (408 Da, Ligand)
GABA-A receptor a5 homomer - a5V3 - RO7015738
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8bhr
Q-score: 0.512
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]-~{n}-[(2~{s})-1-oxidanylpentan-2-yl]pyridine-3-carboxamide (410 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (Complex from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - RO4938581
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8bhs
Q-score: 0.493
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 5-[bis(fluoranyl)methyl]-15-bromanyl-2,4,8,9,11-pentazatetracyclo[11.4.0.0^{2,6}.0^{8,12}]heptadeca-1(13),3,5,9,11,14,16-heptaene (352 Da, Ligand)