CryoEM structure of Ku heterodimer bound to DNA, PAXX and XLF
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 7zyg
Q-score: 0.512
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, Chaplin AK
Sci Adv (2023) 9 pp. eadg2834-eadg2834 [ DOI: doi:10.1126/sciadv.adg2834 Pubmed: 37256950 ]
- Phosphate ion (94 Da, Ligand)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Ku70/80 hetero dimer bound to dna, paxx and xlf (160 kDa, Cellular component from Homo sapiens)
- Dna (4 kDa, DNA from Homo sapiens)
- Dna (4 kDa, DNA from Homo sapiens)
- Protein paxx (21 kDa, Protein from Homo sapiens)
- Non-homologous end-joining factor 1 (33 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
DNA-PK Ku80 mediated dimer bound to PAXX
Resolution: 4.55 Å
EM Method: Single-particle
Fitted PDBs: 8bh3
Q-score: 0.185
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, Chaplin AK
Sci Adv (2023) 9 pp. eadg2834-eadg2834 [ DOI: doi:10.1126/sciadv.adg2834 Pubmed: 37256950 ]
- Dna (26-mer) (8 kDa, DNA from Homo sapiens)
- Dna (25-mer) (7 kDa, DNA from Homo sapiens)
- Nhej supercomplex bound to paxx (1 MDa, Complex from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Dna ligase 4 (104 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- Protein paxx (21 kDa, Protein from Homo sapiens)
- Dna (28-mer) (8 kDa, DNA from Homo sapiens)
- Dna repair protein xrcc4 (38 kDa, Protein from Homo sapiens)
- Dna (27-mer) (8 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
DNA-PK XLF mediated dimer bound to PAXX
Resolution: 4.51 Å
EM Method: Single-particle
Fitted PDBs: 8bhv
Q-score: 0.203
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, Chaplin AK
Sci Adv (2023) 9 pp. eadg2834-eadg2834 [ DOI: doi:10.1126/sciadv.adg2834 Pubmed: 37256950 ]
- Dna (28-mer) (7 kDa, DNA from Homo sapiens)
- Dna (27-mer) (8 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Non-homologous end-joining factor 1 (33 kDa, Protein from Homo sapiens)
- Dna (26-mer) (8 kDa, DNA from Homo sapiens)
- Dna ligase 4 (104 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- Protein paxx (21 kDa, Protein from Homo sapiens)
- Dna-pk xlf mediated dimer bound to paxx (1 MDa, Complex from Homo sapiens)
- Dna repair protein xrcc4 (38 kDa, Protein from Homo sapiens)
- Dna (24-mer) (7 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
DNA-PK Ku80 mediated dimer bound to PAXX and XLF
Resolution: 5.33 Å
EM Method: Single-particle
Fitted PDBs: 8bhy
Q-score: 0.166
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, Chaplin AK
Sci Adv (2023) 9 pp. eadg2834-eadg2834 [ DOI: doi:10.1126/sciadv.adg2834 Pubmed: 37256950 ]
- Dna (25-mer) (7 kDa, DNA from Homo sapiens)
- Dna (5'-d(p*ap*ap*tp*ap*ap*tp*ap*gp*tp*tp*tp*tp*tp*ap*gp*tp*tp*tp*ap*tp*tp*gp*gp*g)-3') (7 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Non-homologous end-joining factor 1 (33 kDa, Protein from Homo sapiens)
- Dna ligase 4 (104 kDa, Protein from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit (469 kDa, Protein from Homo sapiens)
- Protein paxx (21 kDa, Protein from Homo sapiens)
- Dna-pk ku80 mediated dimer bound to paxx and xlf (1 MDa, Cellular component from Homo sapiens)
- Dna repair protein xrcc4 (38 kDa, Protein from Homo sapiens)
- Dna (26-mer) (7 kDa, DNA from Homo sapiens)
- Dna (27-mer) (8 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
CryoEM structure of Ku heterodimer bound to DNA and PAXX
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7zwa
Q-score: 0.523
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, Chaplin AK
Sci Adv (2023) 9 pp. eadg2834-eadg2834 [ DOI: doi:10.1126/sciadv.adg2834 Pubmed: 37256950 ]
- Phosphate ion (94 Da, Ligand)
- Dna (5'-d(p*gp*ap*tp*cp*cp*cp*tp*cp*tp*ap*gp*ap*tp*ap*t)-3') (4 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Ku70/80 heterodimer bound to dna and paxx (150 kDa, Cellular component from Homo sapiens)
- Dna (5'-d(p*cp*gp*ap*tp*ap*tp*cp*tp*ap*gp*ap*gp*gp*gp*ap*tp*c)-3') (4 kDa, DNA from Homo sapiens)
- Protein paxx (21 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)