CryoEM structure of Ku heterodimer bound to DNA
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 7zvt
Q-score: 0.554
Kefala Stavridi A, Gontier A, Morin V, Frit P, Ropars V, Barboule N, Racca C, Jonchhe S, Morten MJ, Andreani J, Rak A, Legrand P, Bourand-Plantefol A, Hardwick SW, Chirgadze DY, Davey P, De Oliveira TM, Rothenberg E, Britton S, Calsou P, Blundell TL, Varela PF, Chaplin AK, Charbonnier JB
Nucleic Acids Res (2023) 51 pp. 11732-11747 [ Pubmed: 37870477 DOI: doi:10.1093/nar/gkad863 ]
- Dna (5'-d(p*cp*gp*ap*tp*ap*tp*cp*tp*ap*gp*ap*gp*gp*gp*ap*t)-3') (4 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 6 (69 kDa, Protein from Homo sapiens)
- Ku70/80 heterodimer bound to dna (150 kDa, Cellular component from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Dna (5'-d(p*tp*cp*cp*cp*tp*cp*tp*ap*gp*ap*tp*ap*tp*c)-3') (4 kDa, DNA from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
Cryo-EM structure of Ku 70/80 bound to inositol hexakisphosphate
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7zt6
Q-score: 0.387
Kefala Stavridi A, Gontier A, Morin V, Frit P, Ropars V, Barboule N, Racca C, Jonchhe S, Morten MJ, Andreani J, Rak A, Legrand P, Bourand-Plantefol A, Hardwick SW, Chirgadze DY, Davey P, De Oliveira TM, Rothenberg E, Britton S, Calsou P, Blundell TL, Varela PF, Chaplin AK, Charbonnier JB
Nucleic Acids Res (2023) 51 pp. 11732-11747 [ Pubmed: 37870477 DOI: doi:10.1093/nar/gkad863 ]
- Inositol hexakisphosphate (660 Da, Ligand)
- Cryo-em structure of ku 70/80 bound to inositol hexakisphosphate (Complex from Homo sapiens)
- X-ray repair cross-complementing protein 6 (73 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (82 kDa, Protein from Homo sapiens)
CryoEM structure of human CMG bound to ATPgammaS and DNA
Rzechorzek NJ, Hardwick SW, Jatikusumo VA, Chirgadze DY, Pellegrini L
Nucleic Acids Res. (2020) 48 pp. 6980-6995 [ Pubmed: 32453425 DOI: 10.1093/nar/gkaa429 ]
Image sets:
CryoEM structure of human CMG bound to AND-1 (CMGA)
Rzechorzek NJ, Hardwick SW, Jatikusumo VA, Chirgadze DY, Pellegrini L
Nucleic Acids Res. (2020) 48 pp. 6980-6995 [ Pubmed: 32453425 DOI: 10.1093/nar/gkaa429 ]
Image sets:
CryoEM structure of human CMG bound to ATPgammaS and DNA
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 6xtx
Q-score: 0.506
Rzechorzek NJ, Hardwick SW, Jatikusumo VA, Chirgadze DY, Pellegrini L
Nucleic Acids Res (2020) 48 pp. 6980-6995 [ DOI: doi:10.1093/nar/gkaa429 Pubmed: 32453425 ]
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Dna replication complex gins protein psf1 (23 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Human cmg helicase (Complex from Homo sapiens)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Dna replication licensing factor mcm4 (99 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna (5'-d(p*tp*tp*tp*tp*tp*tp*tp*tp*tp*tp*t)-3') (21 kDa, DNA from synthetic construct)
- Dna replication complex gins protein psf3 (24 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dna replication complex gins protein psf2 (25 kDa, Protein from Homo sapiens)
- Dna replication complex gins protein sld5 (26 kDa, Protein from Homo sapiens)
- Cell division control protein 45 homolog (65 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm3 (96 kDa, Protein from Homo sapiens)
- Dna (Complex from synthetic construct)
- Complex of human cmg bound to dna (Complex)
CryoEM structure of human CMG bound to ATPgammaS and DNA - MCM2-7 C-tier
Rzechorzek NJ, Hardwick SW, Jatikusumo VA, Chirgadze DY, Pellegrini L
Nucleic Acids Res (2020) 48 pp. 6980-6995 [ DOI: doi:10.1093/nar/gkaa429 Pubmed: 32453425 ]
CryoEM structure of human CMG bound to AND-1 (CMGA)
Resolution: 6.77 Å
EM Method: Single-particle
Fitted PDBs: 6xty
Q-score: 0.127
Rzechorzek NJ, Hardwick SW, Jatikusumo VA, Chirgadze DY, Pellegrini L
Nucleic Acids Res (2020) 48 pp. 6980-6995 [ DOI: doi:10.1093/nar/gkaa429 Pubmed: 32453425 ]
- Dna replication complex gins protein psf3 (24 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Wd repeat and hmg-box dna-binding protein 1 (130 kDa, Protein from Homo sapiens)
- Complex of human cmg bound to and1 (Complex from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication complex gins protein sld5 (26 kDa, Protein from Homo sapiens)
- Cell division control protein 45 homolog (65 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm3 (96 kDa, Protein from Homo sapiens)
- Dna replication complex gins protein psf1 (23 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna replication complex gins protein psf2 (21 kDa, Protein from Homo sapiens)
- Human cmg helicase (Complex from Homo sapiens)
- And1 (Complex from Homo sapiens)