GABA-A receptor a5 homomer - a5V3 - Diazepam
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8bhk
Q-score: 0.495
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- 7-chloro-1-methyl-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one (284 Da, Ligand)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
GABA-A receptor a5 homomer - a5V3 - L655708
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8bho
Q-score: 0.493
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ethyl (7~{s})-15-methoxy-12-oxidanylidene-2,4,11-triazatetracyclo[11.4.0.0^{2,6}.0^{7,11}]heptadeca-1(17),3,5,13,15-pentaene-5-carboxylate (341 Da, Ligand)
GABA-A receptor a5 homomer - a5V3 - RO7172670
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8bhq
Q-score: 0.498
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2-[[5-methyl-3-(6-methylpyridazin-3-yl)-1,2-oxazol-4-yl]methyl]-5-(5-oxa-2-azaspiro[3.5]nonan-2-yl)pyridazin-3-one (408 Da, Ligand)
GABA-A receptor a5 homomer - a5V3 - RO7015738
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8bhr
Q-score: 0.512
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]-~{n}-[(2~{s})-1-oxidanylpentan-2-yl]pyridine-3-carboxamide (410 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (Complex from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - RO4938581
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8bhs
Q-score: 0.493
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 5-[bis(fluoranyl)methyl]-15-bromanyl-2,4,8,9,11-pentazatetracyclo[11.4.0.0^{2,6}.0^{8,12}]heptadeca-1(13),3,5,9,11,14,16-heptaene (352 Da, Ligand)
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 7pbd
Q-score: 0.485
Kasaragod VB, Mortensen M, Hardwick SW, Wahid AA, Dorovykh V, Chirgadze DY, Smart TG, Miller PS
Nature (2022) 602 pp. 529-533 [ DOI: doi:10.1038/s41586-022-04402-z Pubmed: 35140402 ]
- Gamma-aminobutyric acid receptor subunit alpha-1 (47 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Gaba-a receptor - megabody 25 complex (220 kDa, Complex)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Megabody 25 (Complex from Lama glama)
- Histamine (111 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3 (51 kDa, Protein from Homo sapiens)
- Gaba-a receptor (Complex from Homo sapiens)
- Megabody 25 (56 kDa, Protein from Lama glama)
Cryo-EM structure of T275P KatG from M. tuberculosis
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 7a8z
Q-score: 0.506
Munir A, Wilson MT, Hardwick SW, Chirgadze DY, Worrall JAR, Blundell TL, Chaplin AK
Structure (2021) 29 pp. 899-912.e4 [ DOI: doi:10.1016/j.str.2020.12.008 Pubmed: 33444527 ]
T275P after heme uptake from M. tuberculosis
Resolution: 3.56 Å
EM Method: Single-particle
Fitted PDBs: 7aa3
Q-score: 0.5
Munir A, Wilson MT, Hardwick SW, Chirgadze DY, Worrall JAR, Blundell TL, Chaplin AK
Structure (2021) 29 pp. 899-912.e4 [ DOI: doi:10.1016/j.str.2020.12.008 Pubmed: 33444527 ]
Cryo-EM structure of DNA-PKcs:Ku80ct194
Resolution: 3.93 Å
EM Method: Single-particle
Fitted PDBs: 6zh6
Q-score: 0.335
Chaplin AK, Hardwick SW, Liang S, Kefala Stavridi A, Hnizda A, Cooper LR, De Oliveira TM, Chirgadze DY, Blundell TL
Nat Struct Mol Biol (2021) 28 pp. 13-19 [ Pubmed: 33077952 DOI: doi:10.1038/s41594-020-00517-x ]
- Dna-dependent protein kinase catalytic subunit,dna-pkcs (Cellular component from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit,dna-pkcs (472 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (21 kDa, Protein from Homo sapiens)
- X-ray repair cross-complementing protein 5 (Cellular component from Homo sapiens)
- Dna-pkcs in complex with ku80 c-terminal domain (480 kDa, Cellular component)
Cryo-EM structure of DNA-PKcs:DNA
Resolution: 4.14 Å
EM Method: Single-particle
Fitted PDBs: 6zh8
Q-score: 0.277
Chaplin AK, Hardwick SW, Liang S, Kefala Stavridi A, Hnizda A, Cooper LR, De Oliveira TM, Chirgadze DY, Blundell TL
Nat Struct Mol Biol (2021) 28 pp. 13-19 [ Pubmed: 33077952 DOI: doi:10.1038/s41594-020-00517-x ]
- Dna (Cellular component from Homo sapiens)
- Dna-pkcs (Cellular component from Homo sapiens)
- Dna (5'-d(p*ap*gp*tp*tp*tp*tp*tp*ap*gp*tp*t)-3') (3 kDa, DNA from Homo sapiens)
- Dna-pkcs bound to dna (480 kDa, Cellular component)
- Dna (5'-d(p*ap*cp*tp*ap*ap*ap*ap*a)-3') (2 kDa, DNA from Homo sapiens)
- Dna-dependent protein kinase catalytic subunit,dna-pkcs (472 kDa, Protein from Homo sapiens)