Structure of human mitochondrial MRPP1-MRPP2 in complex with mitochondrial pre-tRNA-Ile
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8cbo
Q-score: 0.469
Meynier V, Hardwick SW, Catala M, Roske JJ, Oerum S, Chirgadze DY, Barraud P, Yue WW, Luisi BF, Tisne C
Nat Commun (2024) 15 pp. 4683-4683 [ DOI: doi:10.1038/s41467-024-49132-0 Pubmed: 38824131 ]
- Mitochondrial precursor trna-ile(5,4) (25 kDa, RNA from Homo sapiens)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
- 3-hydroxyacyl-coa dehydrogenase type-2 (26 kDa, Protein from Homo sapiens)
- Mitochondrial pre-trnaile (Complex from Homo sapiens)
- Trna methyltransferase 10 homolog c (24 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Human mitochondrial mrpp1-mrpp2 in complex with mitochondrial pre-trnaile (170 kDa, Complex)
- Human mitochondrial mrpp1-mrpp2 (Complex from Homo sapiens)
Meynier V, Hardwick SW, Catala M, Roske JJ, Oerum S, Chirgadze DY, Barraud P, Yue WW, Luisi BF, Tisne C
Nat Commun (2024) 15 pp. 4683-4683 [ DOI: doi:10.1038/s41467-024-49132-0 Pubmed: 38824131 ]
Cryo-EM structure of human exostosin-like 3 (EXTL3)
Resolution: 2.43 Å
EM Method: Single-particle
Fitted PDBs: 7au2
Q-score: 0.659
Wilson LFL, Dendooven T, Hardwick SW, Echevarria-Poza A, Tryfona T, Krogh KBRM, Chirgadze DY, Luisi BF, Logan DT, Mani K, Dupree P
Nat Commun (2022) 13 pp. 3314-3314 [ Pubmed: 35676258 DOI: doi:10.1038/s41467-022-31048-2 ]
- Exostosin-like 3 (101 kDa, Protein from Homo sapiens)
- Homodimer of extl3 globular domain (170 kDa, Complex from Homo sapiens)
Cryo-EM structure of human exostosin-like 3 (EXTL3) in complex with UDP
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7aua
Q-score: 0.574
Wilson LFL, Dendooven T, Hardwick SW, Echevarria-Poza A, Tryfona T, Krogh KBRM, Chirgadze DY, Luisi BF, Logan DT, Mani K, Dupree P
Nat Commun (2022) 13 pp. 3314-3314 [ Pubmed: 35676258 DOI: doi:10.1038/s41467-022-31048-2 ]
- Exostosin-like 3 (101 kDa, Protein from Homo sapiens)
- Homodimer of extl3 globular domain (170 kDa, Complex from Homo sapiens)
- Manganese (ii) ion (54 Da, Ligand)
- Uridine-5'-diphosphate (404 Da, Ligand)
Human methemoglobin bound to Staphylococcus aureus hemophore IsdB
Resolution: 5.82 Å
EM Method: Single-particle
Fitted PDBs: 7pcf
Q-score: 0.246
De Bei O, Marchetti M, Ronda L, Gianquinto E, Lazzarato L, Chirgadze DY, Hardwick SW, Cooper LR, Spyrakis F, Luisi BF, Campanini B, Bettati S
PNAS (2022) 119 pp. e2116708119-e2116708119 [ Pubmed: 35357971 DOI: doi:10.1073/pnas.2116708119 ]
- Iron-regulated surface determinant protein b (Complex from Staphylococcus aureus subsp. aureus MW2)
- Hemoglobin subunit alpha (15 kDa, Protein from Homo sapiens)
- Iron-regulated surface determinant protein b (43 kDa, Protein from Staphylococcus aureus subsp. aureus MW2)
- Hemoglobin subunit beta (15 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Human methemoglobin bound to staphylococcus aureus hemophore isdb (119 kDa, Complex)
- Hemoglobin (Complex from Homo sapiens)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7qn5
Q-score: 0.58
Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR
Nature (2022) 604 pp. 190-194 [ Pubmed: 35355020 DOI: doi:10.1038/s41586-022-04517-3 ]
- 1,2-dipalmitoyl-sn-glycero-3-phosphate (647 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Nanobody nb25 (13 kDa, Protein from Lama glama)
- Human full-length extrasynaptic alpha4beta3delta gaba(a)r in complex with nanobody nb25 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-4 (61 kDa, Protein from Homo sapiens)
- 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid (238 Da, Ligand)
- Decane (142 Da, Ligand)
- N-octane (114 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit delta (52 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with nanobody Nb25
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7qn6
Q-score: 0.527
Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR
Nature (2022) 604 pp. 190-194 [ Pubmed: 35355020 DOI: doi:10.1038/s41586-022-04517-3 ]
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Human full-length beta3delta gaba(a)r in complex with nanobody nb25 (Complex from Homo sapiens)
- Nanobody nb25 (13 kDa, Protein from Lama glama)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid (238 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit delta (52 kDa, Protein from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7qn7
Q-score: 0.548
Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR
Nature (2022) 604 pp. 190-194 [ Pubmed: 35355020 DOI: doi:10.1038/s41586-022-04517-3 ]
- 1,2-dipalmitoyl-sn-glycero-3-phosphate (647 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-4 (61 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit delta (52 kDa, Protein from Homo sapiens)
- Nanobody nb25 (13 kDa, Protein from Homo sapiens)
- Human full-length extrasynaptic alpha4beta3delta gaba(a)r in complex with gaba, histamine and nanobody nb25 (Complex from Homo sapiens)
- Water (18 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7qn8
Q-score: 0.492
Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR
Nature (2022) 604 pp. 190-194 [ Pubmed: 35355020 DOI: doi:10.1038/s41586-022-04517-3 ]
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Histamine (111 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit delta (52 kDa, Protein from Homo sapiens)
- Nanobody nb25 (13 kDa, Protein from Homo sapiens)
- Human full-length beta3delta gaba(a)r in complex with histamine and nanobody nb25 (Complex from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7qn9
Q-score: 0.505
Sente A, Desai R, Naydenova K, Malinauskas T, Jounaidi Y, Miehling J, Zhou X, Masiulis S, Hardwick SW, Chirgadze DY, Miller KW, Aricescu AR
Nature (2022) 604 pp. 190-194 [ Pubmed: 35355020 DOI: doi:10.1038/s41586-022-04517-3 ]
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-4 (61 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Hexadecane (226 Da, Ligand)
- Human full-length extrasynaptic alpha4beta3delta gaba(a)r in complex with histamine and nanobody nb25 (Complex from Homo sapiens)
- Decane (142 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit delta (52 kDa, Protein from Homo sapiens)
- Nanobody nb25 (13 kDa, Protein from Homo sapiens)