Structure of human mitochondrial RNase P in complex with mitochondrial pre-tRNA-His(5,Ser)
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 8cbk
Q-score: 0.452
Meynier V, Hardwick SW, Catala M, Roske JJ, Oerum S, Chirgadze DY, Barraud P, Yue WW, Luisi BF, Tisne C
Nat Commun (2024) 15 pp. 4683-4683 [ DOI: doi:10.1038/s41467-024-49132-0 Pubmed: 38824131 ]
- Zinc ion (65 Da, Ligand)
- Water (18 Da, Ligand)
- Mitochondrial ribonuclease p catalytic subunit (61 kDa, Protein from Homo sapiens)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
- Human mitochondrial rnase p in complex with mitochondrial pre-trnahis-ser (269 kDa, Complex from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Mitochondrial precursor trna-his(5,ser) (29 kDa, RNA from Homo sapiens)
- Trna methyltransferase 10 homolog c (48 kDa, Protein from Homo sapiens)
- 3-hydroxyacyl-coa dehydrogenase type-2 (26 kDa, Protein from Homo sapiens)
Structure of human mitochondrial RNase Z in complex with mitochondrial pre-tRNA-His(0,Ser)
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8cbl
Q-score: 0.443
Meynier V, Hardwick SW, Catala M, Roske JJ, Oerum S, Chirgadze DY, Barraud P, Yue WW, Luisi BF, Tisne C
Nat Commun (2024) 15 pp. 4683-4683 [ DOI: doi:10.1038/s41467-024-49132-0 Pubmed: 38824131 ]
- Mitochondrial precursor trna-his(0,ser) (40 kDa, RNA from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Human mitochondrial rnase p in complex with mitochondrial pre-trna-his(0,ser) (300 kDa, Complex from Homo sapiens)
- Zinc phosphodiesterase elac protein 2 (92 kDa, Protein from Homo sapiens)
- Trna methyltransferase 10 homolog c (48 kDa, Protein from Homo sapiens)
- 3-hydroxyacyl-coa dehydrogenase type-2 (26 kDa, Protein from Homo sapiens)
Structure of human mitochondrial CCA-adding enzyme in complex with mitochondrial pre-tRNA-Ile
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8cbm
Q-score: 0.428
Meynier V, Hardwick SW, Catala M, Roske JJ, Oerum S, Chirgadze DY, Barraud P, Yue WW, Luisi BF, Tisne C
Nat Commun (2024) 15 pp. 4683-4683 [ DOI: doi:10.1038/s41467-024-49132-0 Pubmed: 38824131 ]
- Water (18 Da, Ligand)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
- Human mitochondrial cca-adding enzyme in complex with mitochondrial pre-trnaile (270 kDa, Complex from Homo sapiens)
- Cytidine-5'-diphosphate (403 Da, Ligand)
- Mitochondrial precursor trna-ile(0,0) (22 kDa, RNA from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Cca trna nucleotidyltransferase 1, mitochondrial (44 kDa, Protein from Homo sapiens)
- Trna methyltransferase 10 homolog c (48 kDa, Protein from Homo sapiens)
- 3-hydroxyacyl-coa dehydrogenase type-2 (26 kDa, Protein from Homo sapiens)
Structure of human mitochondrial MRPP1-MRPP2 in complex with mitochondrial pre-tRNA-Ile
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8cbo
Q-score: 0.469
Meynier V, Hardwick SW, Catala M, Roske JJ, Oerum S, Chirgadze DY, Barraud P, Yue WW, Luisi BF, Tisne C
Nat Commun (2024) 15 pp. 4683-4683 [ DOI: doi:10.1038/s41467-024-49132-0 Pubmed: 38824131 ]
- Mitochondrial precursor trna-ile(5,4) (25 kDa, RNA from Homo sapiens)
- Nicotinamide-adenine-dinucleotide (663 Da, Ligand)
- 3-hydroxyacyl-coa dehydrogenase type-2 (26 kDa, Protein from Homo sapiens)
- Mitochondrial pre-trnaile (Complex from Homo sapiens)
- Trna methyltransferase 10 homolog c (24 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Human mitochondrial mrpp1-mrpp2 in complex with mitochondrial pre-trnaile (170 kDa, Complex)
- Human mitochondrial mrpp1-mrpp2 (Complex from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - APO
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8bej
Q-score: 0.463
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gaba-a a5 homopentamer a5v3 (205 kDa, Complex from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - Basmisanil - HR
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8bha
Q-score: 0.571
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Basmisanil (445 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Gaba-a a5 subunit homopentamer complex called a5v3 (200 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
GABA-A receptor a5 homomer - a5V3 - RO154513
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8bhb
Q-score: 0.587
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Ethyl 8-[(azanylidene-$l^{4}-azanylidene)amino]-5-methyl-6-oxidanylidene-4~{h}-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (326 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Gaba-a a5 homopentamer a5v3 (205 kDa, Complex from Homo sapiens)
GABA-A receptor a5 homomer - a5V3 - RO5211223
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8bhi
Q-score: 0.557
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gaba-a receptor a5 homomer - a5v3 - ro5211223 (205 kDa, Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [1,1-bis(oxidanylidene)-1,4-thiazinan-4-yl]-[6-[[5-methyl-3-(6-methylpyridin-3-yl)-1,2-oxazol-4-yl]methoxy]pyridin-3-yl]methanone (442 Da, Ligand)
GABA-A receptor a5 homomer - a5V3 - Diazepam
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8bhk
Q-score: 0.495
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- 7-chloro-1-methyl-5-phenyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one (284 Da, Ligand)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
GABA-A receptor a5 homomer - a5V3 - DMCM
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8bhm
Q-score: 0.485
Kasaragod VB, Malinauskas T, Wahid AA, Lengyel J, Knoflach F, Hardwick SW, Jones CF, Chen WN, Lucas X, El Omari K, Chirgadze DY, Aricescu AR, Cecere G, Hernandez MC, Miller PS
Nat Struct Mol Biol (2023) 30 pp. 1936-1946 [ Pubmed: 37903907 DOI: doi:10.1038/s41594-023-01133-1 ]
- Gamma-aminobutyric acid receptor subunit alpha-5 (41 kDa, Protein from Homo sapiens)
- Gaba-a a5 subunit of homopentamer complex called a5v3 (205 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Methyl 4-ethyl-6,7-dimethoxy-9h-pyrido[3,4-b]indole-3-carboxylate (314 Da, Ligand)