Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 7tyz
Q-score: 0.391
Chonira V, Kwon YD, Gorman J, Case JB, Ku Z, Simeon R, Casner RG, Harris DR, Olia AS, Stephens T, Shapiro L, Bender MF, Boyd H, Teng IT, Tsybovsky Y, Krammer F, Zhang N, Diamond MS, Kwong PD, An Z, Chen Z
Nat Chem Biol (2023) 19 pp. 284-291 [ DOI: doi:10.1038/s41589-022-01193-2 Pubmed: 36411391 ]
- Spike glycoprotein (138 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Darpin fsr22 (23 kDa, Protein from Escherichia phage EcSzw-2Escherichia coli)
- Darpin fsr22 in complex with sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 4.17 Å
EM Method: Single-particle
Fitted PDBs: 7tz0
Q-score: 0.228
Resolution: 4.11 Å
EM Method: Single-particle
Fitted PDBs: 8dw2
Q-score: 0.351
Chonira V, Kwon YD, Gorman J, Case JB, Ku Z, Simeon R, Casner RG, Harris DR, Olia AS, Stephens T, Shapiro L, Bender MF, Boyd H, Teng IT, Tsybovsky Y, Krammer F, Zhang N, Diamond MS, Kwong PD, An Z, Chen Z
Nat Chem Biol (2023) 19 pp. 284-291 [ Pubmed: 36411391 DOI: doi:10.1038/s41589-022-01193-2 ]
- Darpin sr22 in complex with sars-cov-2 rbd and antibody fabs, s309 and cr3022 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody cr3022 light chain (24 kDa, Protein from Homo sapiens)
- Antibody cr3022 heavy chain (23 kDa, Protein from Homo sapiens)
- Antibody s309 light chain (23 kDa, Protein from Homo sapiens)
- Sr22 (16 kDa, Protein from Escherichia phage EcSzw-2)
- Antibody s309 heavy chain (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 4.26 Å
EM Method: Single-particle
Fitted PDBs: 8dw3
Q-score: 0.337
Chonira V, Kwon YD, Gorman J, Case JB, Ku Z, Simeon R, Casner RG, Harris DR, Olia AS, Stephens T, Shapiro L, Bender MF, Boyd H, Teng IT, Tsybovsky Y, Krammer F, Zhang N, Diamond MS, Kwong PD, An Z, Chen Z
Nat Chem Biol (2023) 19 pp. 284-291 [ DOI: doi:10.1038/s41589-022-01193-2 Pubmed: 36411391 ]
- Darpin sr16m in complex with sars-cov-2 rbd and antibody fabs, s309 and cr3022 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Antibody s309 light chain (23 kDa, Protein from Homo sapiens)
- Antibody cr3022 heavy chain (23 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Antibody s309 heavy chain (24 kDa, Protein from Homo sapiens)
- Antibody cr3022 light chain (24 kDa, Protein from Homo sapiens)
- Anti-sars-cov-2 darpin sr16m (16 kDa, Protein from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7tb8
Q-score: 0.41
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ DOI: doi:10.1126/science.abn8897 Pubmed: 35324257 ]
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-61.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- The heavy chain of sars-cov-2 antiboddy antibody b1-182.1 (13 kDa, Protein from Homo sapiens)
- The heavy chain of sars-cov-2 antibody a19-61.1 (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The light chain of sars-cov-2 antibody b1-182.1 (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (132 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- The light chain of sars-cov-2 antibody a19-61.1 (11 kDa, Protein from Homo sapiens)
Locally refined region of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7tbf
Q-score: 0.498
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- Heavy chain of sars-cov-2 antibody b1-182.1 (24 kDa, Protein from Homo sapiens)
- Light chain of sars-cov-2 antibody a19-61.1 (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of sars-cov-2 antibody a19-61.1 (13 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-61.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of sars-cov-2 antibody b1-182.1 (23 kDa, Protein from Homo sapiens)
Locally refined region of SARS-CoV-2 spike in complex with antibody A19-46.1
Resolution: 5.08 Å
EM Method: Single-particle
Fitted PDBs: 7tc9
Q-score: 0.221
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ DOI: doi:10.1126/science.abn8897 Pubmed: 35324257 ]
- Heavy chain of antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Homo sapiens)
- Light chain of antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibody a19-46.1, local refinement. (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibody A19-46.1
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 7tca
Q-score: 0.282
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ DOI: doi:10.1126/science.abn8897 Pubmed: 35324257 ]
- Heavy chain of antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- Light chain of antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike in complex with antibody a19-46.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibodies A19-46.1 and B1-182.1
Resolution: 3.86 Å
EM Method: Single-particle
Fitted PDBs: 7tcc
Q-score: 0.268
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ DOI: doi:10.1126/science.abn8897 Pubmed: 35324257 ]
- Heavy chain of antibody a19-46.1 (14 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-46.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of antibody b1-182.1 (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of antibody a19-46.1 (11 kDa, Protein from Homo sapiens)
- Heavy chain of antibody b1-182.1 (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 7u0d
Q-score: 0.236
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ DOI: doi:10.1126/science.abn8897 Pubmed: 35324257 ]
- Light chain of sars-cov-2 antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
- Heavy chain of sars-cov-2 antibody b1-182.1 (24 kDa, Protein from Homo sapiens)
- Surface glycoprotein (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of sars-cov-2 antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of sars-cov-2 antibody b1-182.1 (23 kDa, Protein from Homo sapiens)
- Ternary complex of sars-cov-2 omicron rbd in complex with antibodies b1-182.1 and a19-46.1 (Complex from Homo sapiens)