Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 8d21
Q-score: 0.395
Andrews SF, Cominsky LY, Shimberg GD, Gillespie RA, Gorman J, Raab JE, Brand J, Creanga A, Gajjala SR, Narpala S, Cheung CSF, Harris DR, Zhou T, Gordon I, Holman L, Mendoza F, Houser KV, Chen GL, Mascola JR, Graham BS, Kwong PD, Widge A, Dropulic LK, Ledgerwood JE, Kanekiyo M, McDermott AB
Sci Transl Med (2023) 15 pp. eade4976-eade4976 [ DOI: doi:10.1126/scitranslmed.ade4976 Pubmed: 37075126 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1b06 light chain (11 kDa, Protein from Homo sapiens)
- Cryo-em structure of the vrc321 clinical trial, vaccine-elicited, human antibody 1b06 in complex with a stabilized nc99 ha trimer (Complex)
- 1b06 fab with nc99 ha trimer (Complex from Influenza A virus)
- 1b06 heavy chain (13 kDa, Protein from Homo sapiens)
- Hemagglutinin ha1 chain (36 kDa, Protein from Influenza A virus)
- Hemagglutinin ha2 chain (25 kDa, Protein from Influenza A virus)
Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 7tyz
Q-score: 0.391
Chonira V, Kwon YD, Gorman J, Case JB, Ku Z, Simeon R, Casner RG, Harris DR, Olia AS, Stephens T, Shapiro L, Bender MF, Boyd H, Teng IT, Tsybovsky Y, Krammer F, Zhang N, Diamond MS, Kwong PD, An Z, Chen Z
Nat Chem Biol (2023) 19 pp. 284-291 [ Pubmed: 36411391 DOI: doi:10.1038/s41589-022-01193-2 ]
- Darpin fsr22 in complex with sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (138 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Darpin fsr22 (23 kDa, Protein from Escherichia phage EcSzw-2Escherichia coli)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 spike in complex with antibodies B1-182.1 and A19-61.1
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7tb8
Q-score: 0.41
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- The light chain of sars-cov-2 antibody b1-182.1 (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The light chain of sars-cov-2 antibody a19-61.1 (11 kDa, Protein from Homo sapiens)
- The heavy chain of sars-cov-2 antibody a19-61.1 (13 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-61.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (132 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- The heavy chain of sars-cov-2 antiboddy antibody b1-182.1 (13 kDa, Protein from Homo sapiens)
Locally refined region of SARS-CoV-2 spike in complex with antibody A19-46.1
Resolution: 5.08 Å
EM Method: Single-particle
Fitted PDBs: 7tc9
Q-score: 0.221
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike in complex with antibody a19-46.1, local refinement. (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Homo sapiens)
- Light chain of antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibody A19-46.1
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 7tca
Q-score: 0.282
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heavy chain of antibody a19-46.1 (24 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with antibody a19-46.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of antibody a19-46.1 (22 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 Omicron spike in complex with antibodies A19-46.1 and B1-182.1
Resolution: 3.86 Å
EM Method: Single-particle
Fitted PDBs: 7tcc
Q-score: 0.268
Zhou T, Wang L, Misasi J, Pegu A, Zhang Y, Harris DR, Olia AS, Talana CA, Yang ES, Chen M, Choe M, Shi W, Teng IT, Creanga A, Jenkins C, Leung K, Liu T, Stancofski ED, Stephens T, Zhang B, Tsybovsky Y, Graham BS, Mascola JR, Sullivan NJ, Kwong PD
Science (2022) 376 pp. eabn8897-eabn8897 [ Pubmed: 35324257 DOI: doi:10.1126/science.abn8897 ]
- Light chain of antibody a19-46.1 (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike in complex with antibodies b1-182.1 and a19-46.1 (570 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of antibody b1-182.1 (13 kDa, Protein from Homo sapiens)
- Heavy chain of antibody a19-46.1 (14 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Light chain of antibody b1-182.1 (11 kDa, Protein from Homo sapiens)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7l0l
Q-score: 0.555
Andrews SF, Raab JE, Gorman J, Gillespie RA, Cheung CSF, Rawi R, Cominsky LY, Boyington JC, Creanga A, Shen CH, Harris DR, Olia AS, Nazzari AF, Zhou T, Houser KV, Chen GL, Mascola JR, Graham BS, Kanekiyo M, Ledgerwood JE, Kwong PD, McDermott AB
Nat Med (2022) 28 pp. 373-382 [ DOI: doi:10.1038/s41591-021-01636-8 Pubmed: 35115707 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 316-310-1b11 heavy chain (25 kDa, Protein from Homo sapiens)
- Hemagglutinin ha1 chain (38 kDa, Protein from Influenza A virus (A/Canada/720/2005(H2N2)))
- Hemagglutinin ha2 chain (25 kDa, Protein from Influenza A virus (A/Canada/720/2005(H2N2)))
- 316-310-1b11 fab in complex with an h2 can05 ha trimer (Complex from Influenza A virus)
- 316-310-1b11 light chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 7mfg
Q-score: 0.411
Andrews SF, Raab JE, Gorman J, Gillespie RA, Cheung CSF, Rawi R, Cominsky LY, Boyington JC, Creanga A, Shen CH, Harris DR, Olia AS, Nazzari AF, Zhou T, Houser KV, Chen GL, Mascola JR, Graham BS, Kanekiyo M, Ledgerwood JE, Kwong PD, McDermott AB
Nat Med (2022) 28 pp. 373-382 [ DOI: doi:10.1038/s41591-021-01636-8 Pubmed: 35115707 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 310-030-1d06 fab in complex with an h1 nc99 ha trimer (Complex from Influenza A virus)
- 310-030-1d06 light (11 kDa, Protein from Homo sapiens)
- 310-030-1d06 heavy (13 kDa, Protein from Homo sapiens)
- Hemagglutinin ha1 chain (36 kDa, Protein from Influenza A virus)
- Hemagglutinin ha2 chain (25 kDa, Protein from Influenza A virus)
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 6wxl
Q-score: 0.594
Cheung CS, Gorman J, Andrews SF, Rawi R, Reveiz M, Shen CH, Wang Y, Harris DR, Nazzari AF, Olia AS, Raab J, Teng IT, Verardi R, Wang S, Yang Y, Chuang GY, McDermott AB, Zhou T, Kwong PD
Structure (2022) [ Pubmed: 35489332 DOI: doi:10.1016/j.str.2022.04.003 ]
- 1d21 heavy chain (25 kDa, Protein from Homo sapiens)
- Hemagglutinin ha1 chain (35 kDa, Protein from Influenza A virus (A/Shanghai/JS01/2013(H7N9)))
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- H7 sh13 ha trimer (Complex from Influenza A virus)
- 1d12 fab (Complex from Homo sapiens)
- 1d12 light chain (23 kDa, Protein from Homo sapiens)
- Hemagglutinin ha2 chain (25 kDa, Protein from Influenza A virus (A/Shanghai/JS01/2013(H7N9)))
- 1d12 in complex with an h7 sh13 ha trimer (Complex)