Akil C, Ali S, Tran LT, Gaillard J, Li W, Hayashida K, Hirose M, Kato T, Oshima A, Fujishima K, Blanchoin L, Narita A, Robinson RC
Sci Adv (2022) 8 pp. eabm2225-eabm2225 [ DOI: doi:10.1126/sciadv.abm2225 Pubmed: 35333570 ]
Akil C, Ali S, Tran LT, Gaillard J, Li W, Hayashida K, Hirose M, Kato T, Oshima A, Fujishima K, Blanchoin L, Narita A, Robinson RC
Sci Adv (2022) 8 pp. eabm2225-eabm2225 [ DOI: doi:10.1126/sciadv.abm2225 Pubmed: 35333570 ]
Cryo-EM structure of the gastric proton pump complexed with revaprazan
Resolution: 2.76 Å
EM Method: Single-particle
Fitted PDBs: 7w4a
Q-score: 0.536
Tanaka S, Morita M, Yamagishi T, Madapally HV, Hayashida K, Khandelia H, Gerle C, Shigematsu H, Oshima A, Abe K
J Med Chem (2022) 65 pp. 7843-7853 [ DOI: doi:10.1021/acs.jmedchem.2c00338 Pubmed: 35604136 ]
- Potassium-transporting atpase alpha chain 1 (114 kDa, Protein from Sus scrofa)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-(4-fluorophenyl)-4,5-dimethyl-6-[(1r)-1-methyl-3,4-dihydro-1h-isoquinolin-2-yl]pyrimidin-2-amine (362 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Gastric proton pump (135 kDa, Complex from Sus scrofa)
- Magnesium ion (24 Da, Ligand)
- Potassium-transporting atpase subunit beta (33 kDa, Protein from Sus scrofa)
- Water (18 Da, Ligand)
Cryo-EM structure of the N-terminal deletion mutant of human pannexin-1 in a nanodisc
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 7wsv
Q-score: 0.325
Kuzuya M, Hirano H, Hayashida K, Watanabe M, Kobayashi K, Terada T, Mahmood MI, Tama F, Tani K, Fujiyoshi Y, Oshima A
Sci Signal (2022) 15 pp. eabg6941-eabg6941 [ DOI: doi:10.1126/scisignal.abg6941 Pubmed: 35133866 ]
Cryo-EM structure of human pannexin-1 in a nanodisc
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7f8j
Q-score: 0.48
Kuzuya M, Hirano H, Hayashida K, Watanabe M, Kobayashi K, Terada T, Mahmood MI, Tama F, Tani K, Fujiyoshi Y, Oshima A
Sci Signal (2022) 15 pp. eabg6941-eabg6941 [ DOI: doi:10.1126/scisignal.abg6941 Pubmed: 35133866 ]
- Heptamar of human pannexin-1 channel in a nanodisc (Complex from Homo sapiens)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Pannexin-1 (48 kDa, Protein from Homo sapiens)
Human pannexin-1 showing a conformational change in the N-terminal domain and blocked pore
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7f8n
Q-score: 0.488
Kuzuya M, Hirano H, Hayashida K, Watanabe M, Kobayashi K, Terada T, Mahmood MI, Tama F, Tani K, Fujiyoshi Y, Oshima A
Sci Signal (2022) 15 pp. eabg6941-eabg6941 [ DOI: doi:10.1126/scisignal.abg6941 Pubmed: 35133866 ]
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Pannexin-1 (48 kDa, Protein from Homo sapiens)
- Human pannexin-1 (Complex from Homo sapiens)
Cryo-EM structure of the C-terminal deletion mutant of human PANX1 in a nanodisc
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7f8o
Q-score: 0.444
Kuzuya M, Hirano H, Hayashida K, Watanabe M, Kobayashi K, Terada T, Mahmood MI, Tama F, Tani K, Fujiyoshi Y, Oshima A
Sci Signal (2022) 15 pp. eabg6941-eabg6941 [ DOI: doi:10.1126/scisignal.abg6941 Pubmed: 35133866 ]
- Heptamar of human pannexin-1 channel in a nanodisc (Complex from Homo sapiens)
- 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (760 Da, Ligand)
- Pannexin-1 (48 kDa, Protein from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7vsg
Q-score: 0.434
Nakanishi H, Hayashida K, Nishizawa T, Oshima A, Abe K
J Biol Chem (2022) 298 pp. 101498-101498 [ DOI: doi:10.1016/j.jbc.2021.101498 Pubmed: 34922944 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Phospholipid-transporting atpase ig (124 kDa, Protein from Homo sapiens)
- Cryo-em structure of a human atp11c-cdc50a flippase reconstituted in the nanodisc in ptdser-occluded e2-pi state. (Complex from Homo sapiens)
- O-[(s)-({(2r)-2,3-bis[(9z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-l-serine (788 Da, Ligand)
- Cell cycle control protein 50a (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of a human ATP11C-CDC50A flippase reconstituted in the Nanodisc in E1P state.
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7vsh
Q-score: 0.513
Nakanishi H, Hayashida K, Nishizawa T, Oshima A, Abe K
J Biol Chem (2022) 298 pp. 101498-101498 [ DOI: doi:10.1016/j.jbc.2021.101498 Pubmed: 34922944 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of a human atp11c-cdc50a flippase reconstituted in the nanodisc in e1p state. (Complex from Homo sapiens)
- O-[(s)-({(2r)-2,3-bis[(9z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-l-serine (788 Da, Ligand)
- Phospholipid-transporting atpase ig (124 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Cell cycle control protein 50a (40 kDa, Protein from Homo sapiens)
- Tetrafluoroaluminate ion (102 Da, Ligand)