Rat TRPV2 WT bound to probenecid
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
- Homotetramer of rat trpv2 wt (Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
Rat TRPV2 WT in the presence of probenecid and 2-APB
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
Rat TRPV2 E724A/D725A bound to 2-APB
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
- Homotetramer of rat trpv2 e724a/d725a mutant (Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
- 2-aminoethyl diphenylborinate (225 Da, Ligand)
Rat TRPV2 E724A/D725A bound to probenecid
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- Homotetramer of rat trpv2 e724a/d725a mutant (Complex from Rattus norvegicus)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
Rat TRPV2 E724A/D725A bound to probenecid and 2-APB
Rocereta JA, Sturhahn T, Pumroy RA, Fricke TC, Herzog C, Leffler A, Moiseenkova-Bell V
Nat Struct Mol Biol (2025) [ Pubmed: 39972168 DOI: doi:10.1038/s41594-025-01494-9 ]
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- Homotetramer of rat trpv2 e724a/d725a mutant (Complex from Rattus norvegicus)
- 2-aminoethyl diphenylborinate (225 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 2 (86 kDa, Protein from Rattus norvegicus)
- 1,2-didecanoyl-sn-glycero-3-phosphoethanolamine (522 Da, Ligand)
Apo rat TRPV2 in nanodiscs, state 1
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8ekp
Q-score: 0.599
Haug FM, Pumroy RA, Sridhar A, Pantke S, Dimek F, Fricke TC, Hage A, Herzog C, Echtermeyer FG, de la Roche J, Koh A, Kotecha A, Howard RJ, Lindahl E, Moiseenkova-Bell V, Leffler A
EMBO J (2024) 43 pp. 2264-2290 [ DOI: doi:10.1038/s44318-024-00106-4 Pubmed: 38671253 ]
Apo rat TRPV2 in nanodiscs, state 2
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8ekq
Q-score: 0.625
Haug FM, Pumroy RA, Sridhar A, Pantke S, Dimek F, Fricke TC, Hage A, Herzog C, Echtermeyer FG, de la Roche J, Koh A, Kotecha A, Howard RJ, Lindahl E, Moiseenkova-Bell V, Leffler A
EMBO J (2024) 43 pp. 2264-2290 [ DOI: doi:10.1038/s44318-024-00106-4 Pubmed: 38671253 ]
Apo rat TRPV2 in nanodiscs, state 3
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8ekr
Q-score: 0.521
Haug FM, Pumroy RA, Sridhar A, Pantke S, Dimek F, Fricke TC, Hage A, Herzog C, Echtermeyer FG, de la Roche J, Koh A, Kotecha A, Howard RJ, Lindahl E, Moiseenkova-Bell V, Leffler A
EMBO J (2024) 43 pp. 2264-2290 [ DOI: doi:10.1038/s44318-024-00106-4 Pubmed: 38671253 ]
rat TRPV2 in nanodiscs in the presence of weak acid at pH 5
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8eks
Q-score: 0.54
Haug FM, Pumroy RA, Sridhar A, Pantke S, Dimek F, Fricke TC, Hage A, Herzog C, Echtermeyer FG, de la Roche J, Koh A, Kotecha A, Howard RJ, Lindahl E, Moiseenkova-Bell V, Leffler A
EMBO J (2024) 43 pp. 2264-2290 [ DOI: doi:10.1038/s44318-024-00106-4 Pubmed: 38671253 ]