Cryo-EM structure of human uMtCK1 in complex with ADP
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 9b04
Q-score: 0.548
Demir M, Koepping L, Li Y, Fujimoto L, Bobkov A, Zhao J, Hitosugi T, Sergienko E
Structure (2025) [ Pubmed: 39904336 DOI: doi:10.1016/j.str.2025.01.008 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Creatine kinase u-type, mitochondrial (47 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Octameric u-type mitochondrial creatine kinase (Complex from Homo sapiens)
Cryo-EM structure of human uMtCK1
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9b05
Q-score: 0.531
Demir M, Koepping L, Li Y, Fujimoto L, Bobkov A, Zhao J, Hitosugi T, Sergienko E
Structure (2025) [ Pubmed: 39904336 DOI: doi:10.1016/j.str.2025.01.008 ]
Cryo-EM structure of E227Q variant of uMtCK1 in complex with transition state analog
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 9b0t
Q-score: 0.53
Demir M, Koepping L, Li Y, Fujimoto L, Bobkov A, Zhao J, Hitosugi T, Sergienko E
Structure (2025) [ Pubmed: 39904336 DOI: doi:10.1016/j.str.2025.01.008 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- N-[(e)-amino(imino)methyl]-n-methylglycine (131 Da, Ligand)
- Octameric u-type mitochondrial creatine kinase (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Nitrate ion (62 Da, Ligand)
- Creatine kinase u-type, mitochondrial (47 kDa, Protein from Homo sapiens)
Cryo-EM structure of E227Q variant of uMtCK1 incubated with ADP and phosphocreatine at pH 8.0
Resolution: 2.44 Å
EM Method: Single-particle
Fitted PDBs: 9b0u
Q-score: 0.564
Demir M, Koepping L, Li Y, Fujimoto L, Bobkov A, Zhao J, Hitosugi T, Sergienko E
Structure (2025) [ Pubmed: 39904336 DOI: doi:10.1016/j.str.2025.01.008 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Phosphate ion (94 Da, Ligand)
- N-[(e)-amino(imino)methyl]-n-methylglycine (131 Da, Ligand)
- Octameric u-type mitochondrial creatine kinase (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Creatine kinase u-type, mitochondrial (47 kDa, Protein from Homo sapiens)
Cryo-EM structure of human uMtCK1 in complex with transition state analog
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 9b14
Q-score: 0.597
Demir M, Koepping L, Li Y, Fujimoto L, Bobkov A, Zhao J, Hitosugi T, Sergienko E
Structure (2025) [ Pubmed: 39904336 DOI: doi:10.1016/j.str.2025.01.008 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- N-[(e)-amino(imino)methyl]-n-methylglycine (131 Da, Ligand)
- Creatine kinase u-type, mitochondrial (47 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Octameric u-type mitochondrial creatine kinase (Complex from Homo sapiens)
Cryo-EM structure of human uMtCK1 in complex with ADP and covalent inhibitor CKi
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 9b16
Q-score: 0.509
Demir M, Koepping L, Li Y, Fujimoto L, Bobkov A, Zhao J, Hitosugi T, Sergienko E
Structure (2025) [ Pubmed: 39904336 DOI: doi:10.1016/j.str.2025.01.008 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- (2s)-4-(chloroacetyl)-3,4-dihydro-2h-1,4-benzoxazine-2-carboxamide (254 Da, Ligand)
- Creatine kinase u-type, mitochondrial (47 kDa, Protein from Homo sapiens)
- Octameric u-type mitochondrial creatine kinase (Complex from Homo sapiens)