Alzheimer's Disease Seeded 0N3R Tau Fibrils
Resolution: 2.97 Å
EM Method: Helical reconstruction
Fitted PDBs: 9cgx
Q-score: 0.541
Duan P, Dregni AJ, Xu H, Changolkar L, Lee VM, Lee EB, Hong M
J Biol Chem (2024) 300 pp. 107730-107730 [ DOI: doi:10.1016/j.jbc.2024.107730 Pubmed: 39214304 ]
Alzheimer's Disease Seeded Mixed 0N4R and 0N3R Tau Fibrils
Resolution: 2.69 Å
EM Method: Helical reconstruction
Fitted PDBs: 9cgz
Q-score: 0.56
Duan P, Dregni AJ, Xu H, Changolkar L, Lee VM, Lee EB, Hong M
J Biol Chem (2024) 300 pp. 107730-107730 [ DOI: doi:10.1016/j.jbc.2024.107730 Pubmed: 39214304 ]
AT8-Phosphomimetic Tau Filaments (Full-length, Cofactor-Free 0N4R Tau S202E, T205E, S208E)
Resolution: 2.6 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ttl
Q-score: 0.598
Mammeri NE, Dregni AJ, Duan P, Hong M
PNAS (2024) 121 pp. e2316175121-e2316175121 [ DOI: doi:10.1073/pnas.2316175121 Pubmed: 38408247 ]
- At8-phosphomimetic 0n4r tau fibrils (Complex from Homo sapiens)
- Microtubule-associated protein tau (40 kDa, Protein from Homo sapiens)
PHF1-Phosphomimetic Tau Filaments (Full-length, Cofactor-Free 0N4R Tau S396E, S400E, T403E, S404E)
Resolution: 2.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ttn
Q-score: 0.574
Mammeri NE, Dregni AJ, Duan P, Hong M
PNAS (2024) 121 pp. e2316175121-e2316175121 [ DOI: doi:10.1073/pnas.2316175121 Pubmed: 38408247 ]
- Phf1-phosphomimetic 0n4r tau fibrils (Complex from Homo sapiens)
- Microtubule-associated protein tau (40 kDa, Protein from Homo sapiens)
Resolution: 2.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 9bbl
Q-score: 0.629
J Biol Chem (2024) 300 pp. 107326-107326 [ DOI: doi:10.1016/j.jbc.2024.107326 Pubmed: 38679331 ]
PHF filament generated from 4E-Tau(297-407) under neutral Mg2+ condition
Resolution: 3.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 9bbm
Q-score: 0.51
J Biol Chem (2024) 300 pp. 107326-107326 [ DOI: doi:10.1016/j.jbc.2024.107326 Pubmed: 38679331 ]
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 7yhk
Q-score: 0.556
Li T, Chen J, Zheng Q, Xue W, Zhang L, Rong R, Zhang S, Wang Q, Hong M, Zhang Y, Cui L, He M, Lu Z, Zhang Z, Chi X, Li J, Huang Y, Wang H, Tang J, Ying D, Zhou L, Wang Y, Yu H, Zhang J, Gu Y, Chen Y, Li S, Xia N
Nat Commun (2022) 13 pp. 5182-5182 [ DOI: doi:10.1038/s41467-022-32926-5 Pubmed: 36056024 ]
- Neutralizing antibody 12h5 (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 12h5 light chain (12 kDa, Protein from Mus musculus)
- Cryo-em structure of the ha trimer of a/beijing/262/1995(h1n1) in complex with neutralizing antibody 12h5 (Complex)
- 12h5 heavy chain (12 kDa, Protein from Mus musculus)
- Hemagglutinin (62 kDa, Protein from Influenza A virus (A/Beijing/262/1995(H1N1)))
- Ha trimer of a/beijing/262/1995(h1n1) (Complex from Influenza A virus (A/Beijing/262/1995(H1N1)))
Antibody Recognition of the Pandemic H1N1 Influenza Hemagglutinin Receptor Binding Site
Hong M, Lee PS, Hoffman RM, Zhu X, Krause JC, Laursen NS, Yoon SI, Song L, Tussey L, Crowe JE, Ward AB, Wilson IA
J Virol (2013) 87 pp. 12471-12480 [ DOI: doi:10.1128/JVI.01388-13 Pubmed: 24027321 ]