Engineered peptide-specific binder in complex with HLA-DR1/CLIP
Du H, Liu J, Jude KM, Yang X, Li Y, Bell B, Yang H, Kassardjian A, Blackson W, Mobedi A, Parekh U, Parra Sperberg RA, Julien JP, Mellins ED, Garcia KC, Huang PS
Nat Biotechnol (2024) [ Pubmed: 39672953 DOI: doi:10.1038/s41587-024-02466-y ]
- C44h10 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Engineered peptide-specific binder in complex with hla-dr1/clip (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Class-ii-associated invariant chain peptide (1 kDa, Protein from Homo sapiens)
- Hla class ii histocompatibility antigen dr beta chain (22 kDa, Protein from Homo sapiens)
- Superantigen (15 kDa, Protein from Metamycoplasma arthritidis)
- Hla class ii histocompatibility antigen, dr alpha chain (21 kDa, Protein from Homo sapiens)
- C44h10 fab light chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 8dt8
Q-score: 0.443
Misson Mindrebo L, Liu H, Ozorowski G, Tran Q, Woehl J, Khalek I, Smith JM, Barman S, Zhao F, Keating C, Limbo O, Verma M, Liu J, Stanfield RL, Zhu X, Turner HL, Sok D, Huang PS, Burton DR, Ward AB, Wilson IA, Jardine JG
PNAS (2023) 120 pp. e2216612120-e2216612120 [ Pubmed: 37276407 DOI: doi:10.1073/pnas.2216612120 ]
- Lm18/nb136 bispecific tetra-nanobody immunoglobulin in complex with sars-cov-2-6p-mut7 s protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Lm18 nanobody (14 kDa, Protein from synthetic construct)
- Nb136 nanobody (13 kDa, Protein from synthetic construct)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Misson Mindrebo L, Liu H, Ozorowski G, Tran Q, Woehl J, Khalek I, Smith JM, Barman S, Zhao F, Keating C, Limbo O, Verma M, Liu J, Stanfield RL, Zhu X, Turner HL, Sok D, Huang PS, Burton DR, Ward AB, Wilson IA, Jardine JG
PNAS (2023) 120 pp. e2216612120-e2216612120 [ Pubmed: 37276407 DOI: doi:10.1073/pnas.2216612120 ]
The oligomerized complex of hemolysin AF3 mutant protomers.
Ghanem N, Kanagami N, Matsui T, Takeda K, Kaneko J, Shiraishi Y, Choe CA, Uchikubo-Kamo T, Shirouzu M, Hashimoto T, Ogawa T, Matsuura T, Huang PS, Yokoyama T, Tanaka Y
FEBS J (2022) 289 pp. 3505-3520 [ Pubmed: 35030303 DOI: doi:10.1111/febs.16354 ]
The oligomerized complex of AG2 hemolysin mutant protomers
Ghanem N, Kanagami N, Matsui T, Takeda K, Kaneko J, Shiraishi Y, Choe CA, Uchikubo-Kamo T, Shirouzu M, Hashimoto T, Ogawa T, Matsuura T, Huang PS, Yokoyama T, Tanaka Y
FEBS J (2022) 289 pp. 3505-3520 [ Pubmed: 35030303 DOI: doi:10.1111/febs.16354 ]
Resolution: 4.33 Å
EM Method: Helical reconstruction
Fitted PDBs: 7kch
Q-score: 0.207
Ruijgrok PV, Ghosh RP, Zemsky S, Nakamura M, Gong R, Ning L, Chen R, Vachharajani VT, Chu AE, Anand N, Eguchi RR, Huang PS, Lin MZ, Alushin GM, Liphardt JT, Bryant Z
Nat Chem Biol (2021) 17 pp. 540-548 [ Pubmed: 33603247 DOI: doi:10.1038/s41589-021-00740-7 ]
- Myosin xi-f-actin complex (209 MDa, Complex from Gallus gallus)
- Actin, alpha skeletal muscle (42 kDa, Protein from Gallus gallus)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Unconventional myosin heavy chain (83 kDa, Protein from Chara corallina)
A de novo designed transmembrane nanopore, TMH4C4
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 6m6z
Q-score: 0.126
Xu C, Lu P, Gamal El-Din TM, Pei XY, Johnson MC, Uyeda A, Bick MJ, Xu Q, Jiang D, Bai H, Reggiano G, Hsia Y, Brunette TJ, Dou J, Ma D, Lynch EM, Boyken SE, Huang PS, Stewart L, DiMaio F, Kollman JM, Luisi BF, Matsuura T, Catterall WA, Baker D
Nature (2020) 585 pp. 129-134 [ Pubmed: 32848250 DOI: doi:10.1038/s41586-020-2646-5 ]
- A de novo designed transmembrane nanopore (Complex from Escherichia coli)
- Tmh4c4 (23 kDa, Protein from Escherichia coli)
Pejchal R, Doores KJ, Walker LM, Khayat R, Huang PS, Wang SK, Stanfield RL, Julien JP, Ramos A, Crispin M, Depetris R, Katpally U, Marozsan A, Cupo A, Maloveste S, Liu Y, McBride R, Ito Y, Sanders RW, Ogohara C, Paulson JC, Feizi T, Scanlan CN, Wong CH, Moore JP, Olson WC, Ward AB, Poignard P, Schief WR, Burton DR, Wilson IA
Science (2011) 334 pp. 1097-1103 [ Pubmed: 21998254 DOI: doi:10.1126/science.1213256 ]