Human proton sensing receptor GPR68 in complex with miniGs
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9bhm
Q-score: 0.456
Howard MK, Hoppe N, Huang XP, Mitrovic D, Billesbolle CB, Macdonald CB, Mehrotra E, Rockefeller Grimes P, Trinidad DD, Delemotte L, English JG, Coyote-Maestas W, Manglik A
Cell (2025) 188 pp. 671- [ DOI: doi:10.1016/j.cell.2024.11.036 Pubmed: 39753132 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Complex of gpr68 bound to gs heterotrimer (Complex)
- Ovarian cancer g-protein coupled receptor 1 (42 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
Human proton sensing receptor GPR68 in complex with miniGsq
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9bi6
Q-score: 0.567
Howard MK, Hoppe N, Huang XP, Mitrovic D, Billesbolle CB, Macdonald CB, Mehrotra E, Rockefeller Grimes P, Trinidad DD, Delemotte L, English JG, Coyote-Maestas W, Manglik A
Cell (2025) 188 pp. 671-687.e20 [ DOI: doi:10.1016/j.cell.2024.11.036 Pubmed: 39753132 ]
- Complex of gpr68 bound to gq heterotrimer (Complex from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Minigsq (26 kDa, Protein from synthetic construct)
- Ovarian cancer g-protein coupled receptor 1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant, scFv16, and dopamine
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG
Nat Commun (2024) 15 pp. 6643-6643 [ DOI: doi:10.1038/s41467-024-50964-z Pubmed: 39103320 ]
- Human drd2 in complex with heterotrimeric g protein goa (k46e), scfv16, and dopamine (120 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Escherichia coli)
- D(2) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
CryoEM structure of D2 dopamine receptor in complex with GoA KE mutant and dopamine
Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG
Nat Commun (2024) 15 pp. 6643-6643 [ DOI: doi:10.1038/s41467-024-50964-z Pubmed: 39103320 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- D(2) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (40 kDa, Protein from Homo sapiens)
- L-dopamine (153 Da, Ligand)
- Human drd2 in complex with heterotrimeric g protein goa (k46e) and dopamine (120 kDa, Complex from Homo sapiens)
Dopamine Receptor D1R-Gs-Rotigotine complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8irr
Q-score: 0.513
Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE
Cell Res (2023) 33 pp. 604-616 [ DOI: doi:10.1038/s41422-023-00808-0 Pubmed: 37221270 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (55 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Nanoboy 35 (14 kDa, Protein from Lama glama)
- Rotigotine (315 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Dopamine receptor d1r-gs-rotigotine complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Dopamine Receptor D4R-Gi-Rotigotine complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8iru
Q-score: 0.485
Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE
Cell Res (2023) 33 pp. 604-616 [ DOI: doi:10.1038/s41422-023-00808-0 Pubmed: 37221270 ]
- Dopamine receptor d4r-gi-rotigotine complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- D(4) dopamine receptor (83 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Rotigotine (315 Da, Ligand)
- Scfv16 (26 kDa, Protein from Mus musculus)
Dopamine Receptor D2R-Gi-Rotigotine complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8irs
Q-score: 0.468
Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE
Cell Res (2023) 33 pp. 604-616 [ DOI: doi:10.1038/s41422-023-00808-0 Pubmed: 37221270 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Dopamine receptor d2r-gi-rotigotine complex (Complex from Homo sapiens)
- Soluble cytochrome b562,d(2) dopamine receptor (67 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Rotigotine (315 Da, Ligand)
- Scfv16 (26 kDa, Protein from Mus musculus)
Dopamine Receptor D3R-Gi-Rotigotine complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8irt
Q-score: 0.564
Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE
Cell Res (2023) 33 pp. 604-616 [ DOI: doi:10.1038/s41422-023-00808-0 Pubmed: 37221270 ]
- Dopamine receptor d3r-gi-rotigotine complex (Complex from Homo sapiens)
- Soluble cytochrome b562,d(3) dopamine receptor (60 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Rotigotine (315 Da, Ligand)
- Scfv16 (26 kDa, Protein from Mus musculus)
Dopamine Receptor D5R-Gs-Rotigotine complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8irv
Q-score: 0.517
Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE
Cell Res (2023) 33 pp. 604-616 [ DOI: doi:10.1038/s41422-023-00808-0 Pubmed: 37221270 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Dopamine receptor d5r-gs-rotigotine complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Rotigotine (315 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,d(1b) dopamine receptor (68 kDa, Protein from Homo sapiens)
Cryo-EM structure of human angiotensin receptor AT1R in complex Gq proteins and Sar1-AngII
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7f6g
Q-score: 0.504
Zhang D, Liu Y, Zaidi SA, Xu L, Zhan Y, Chen A, Guo J, Huang XP, Roth BL, Katritch V, Cherezov V, Zhang H
EMBO J (2023) 42 pp. e112940-e112940 [ DOI: doi:10.15252/embj.2022112940 Pubmed: 37038975 ]
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(q) subunit alpha (43 kDa, Protein from Homo sapiens)
- Angiotensin receptor at1r in complex with gq proteins and sar1-angii (168 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin receptor at1r (81 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
- Sar1-angii (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)