Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 7swd
Q-score: 0.449
Milligan JC, Davis CW, Yu X, Ilinykh PA, Huang K, Halfmann PJ, Cross RW, Borisevich V, Agans KN, Geisbert JB, Chennareddy C, Goff AJ, Piper AE, Hui S, Shaffer KCL, Buck T, Heinrich ML, Branco LM, Crozier I, Holbrook MR, Kuhn JH, Kawaoka Y, Glass PJ, Bukreyev A, Geisbert TW, Worwa G, Ahmed R, Saphire EO
Cell (2022) 185 pp. 995-1007.e18 [ Pubmed: 35303429 DOI: doi:10.1016/j.cell.2022.02.023 ]
- Complex of ebov gp lacking the mucin-like-domain with 1c11 scfv and 1c3 fab (300 kDa, Complex from Homo sapiens)
- 1c3 light chain (12 kDa, Protein from Homo sapiens)
- 1c3 heavy chain (13 kDa, Protein from Homo sapiens)
- 1c11 scfv (26 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein gp2 (10 kDa, Protein from Zaire ebolavirus)
- Virion spike glycoprotein gp1 (31 kDa, Protein from Ebola virus - Gabon (1994-1997))
EBOV GPdMuc (Makona) in complex with rEBOV-520 and rEBOV-548 Fabs
Resolution: 4.12 Å
EM Method: Single-particle
Fitted PDBs: 6pci
Q-score: 0.38
Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe Jr JE
Immunity (2020) 52 pp. 388-403.e12 [ DOI: doi:10.1016/j.immuni.2020.01.001 Pubmed: 32023489 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ebola virus (makona) gp (Complex)
- Rebov-520 fab (Complex)
- Rebov-520 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein,virion spike glycoprotein,ebola virus (makona) gp2 (22 kDa, Protein from Ebola virus)
- Rebov-548 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein (31 kDa, Protein from Ebola virus)
- Rebov-520 fab light chain (23 kDa, Protein from Homo sapiens)
- Rebov-548 fab light chain (23 kDa, Protein from Homo sapiens)
- Ebov gpdmuc (makona) in complex with rebov-520 and rebov-548 fabs (450 kDa, Complex from Homo sapiens)
- Rebov-548 fab (Complex)
EBOV GPdMuc Makona bound to rEBOV-548 Fab
Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 6uye
Q-score: 0.413
Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe Jr JE
Immunity (2020) 52 pp. 388-403.e12 [ DOI: doi:10.1016/j.immuni.2020.01.001 Pubmed: 32023489 ]
- Ebola virus, mucin deleted, strain makona (Complex from Ebola virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sgp (29 kDa, Protein from Ebola virus)
- Antibody rebov-548 fab, light chain (11 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein (10 kDa, Protein from Ebola virus)
- Rebov-548 fab (Complex from Homo sapiens)
- Antibody rebov-548 fab, heavy chain (14 kDa, Protein from Homo sapiens)
- Complex of ebola virus, mucin deleted, strain makona in complex with rebov-548 fab (Complex)