RO76 bound muOR-Gi1-scFv16 complex structure
Ople RS, Ramos-Gonzalez N, Li Q, Sobecks BL, Aydin D, Powers AS, Faouzi A, Polacco BJ, Bernhard SM, Appourchaux K, Sribhashyam S, Eans SO, Tsai BA, Dror RO, Varga BR, Wang H, Huttenhain R, McLaughlin JP, Majumdar S
ACS Cent Sci (2024) 10 pp. 1490-1503 [ DOI: doi:10.1021/acscentsci.4c00525 Pubmed: 39220695 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Ro76 bound muor-gi1-scfv16 complex (Complex from Mus musculus)
- N-{[3-(hydroxymethyl)phenyl]methyl}-n-[1-(2-phenylethyl)piperidin-4-yl]propanamide (380 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Mu-type opioid receptor (39 kDa, Protein from Mus musculus)
5-HT2B receptor bound to LSD obtained by cryo-electron microscopy (cryoEM)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7srq
Q-score: 0.446
Cao C, Barros-Alvarez X, Zhang S, Kim K, Damgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Huttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL
Neuron (2022) 110 pp. 3154- [ Pubmed: 36087581 DOI: doi:10.1016/j.neuron.2022.08.006 ]
- 5-hydroxytryptamine receptor 2b (35 kDa, Protein from Homo sapiens)
- (8alpha)-n,n-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide (323 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 5-ht2b receptor bound to lsd (Complex from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7srr
Q-score: 0.564
Cao C, Barros-Alvarez X, Zhang S, Kim K, Damgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Huttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL
Neuron (2022) 110 pp. 3154- [ Pubmed: 36087581 DOI: doi:10.1016/j.neuron.2022.08.006 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 5-ht2b receptor bound to lsd in complex with heterotrimeric mini-gq protein and single-chain variable fragment (scfv16) (Complex from Homo sapiens)
- Single-chain variable fragment 16 (scfv16) (30 kDa, Protein from Homo sapiens)
- 5-hydroxytryptamine receptor 2b (41 kDa, Protein from Homo sapiens)
- (8alpha)-n,n-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide (323 Da, Ligand)
- G protein subunit q (gi2-mini-gq chimera) (28 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7srs
Q-score: 0.523
Cao C, Barros-Alvarez X, Zhang S, Kim K, Damgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Huttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL
Neuron (2022) 110 pp. 3154- [ Pubmed: 36087581 DOI: doi:10.1016/j.neuron.2022.08.006 ]
- Anti-5ht2br fab heavy chain (23 kDa, Protein from Mus musculus)
- Fab30 light chain (11 kDa, Protein from Mus musculus)
- Isoform 1b of beta-arrestin-1 (41 kDa, Protein from Homo sapiens)
- 5-ht2b receptor bound to lsd in complex with beta-arrestin1 (Complex)
- Anti-5ht2br fab light chain (22 kDa, Protein from Mus musculus)
- Fab30 heavy chain (13 kDa, Protein from Mus musculus)
- (8alpha)-n,n-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide (323 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 5-hydroxytryptamine receptor 2b (37 kDa, Protein from Homo sapiens)
Structure of human SetD3 methyl-transferase in complex with 2A protease from Coxsackievirus B3
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7lms
Q-score: 0.452
Peters CE, Schulze-Gahmen U, Eckhardt M, Jang GM, Xu J, Pulido EH, Bardine C, Craik CS, Ott M, Gozani O, Verba KA, Huttenhain R, Carette JE, Krogan NJ
Nat Commun (2022) 13 pp. 5282-5282 [ Pubmed: 36075902 DOI: doi:10.1038/s41467-022-32758-3 ]
- Protease 2a (16 kDa, Protein from Coxsackievirus B3 (strain Nancy))
- Ternary complex of coxsackievirus b3 2a protease and human setd3 methyltransferase (84 kDa, Complex from Coxsackievirus B3 (strain Nancy))
- Zinc ion (65 Da, Ligand)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Actin-histidine n-methyltransferase (67 kDa, Protein from Homo sapiens)