KSHV glycoprotein B ectodomain, postfusion form
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9cu4
Q-score: 0.492
Ito F, Zhen J, Xie G, Huang H, Silva JC, Wu T-T, Zhou ZH
J Virol (2025) pp. e0153324-e0153324 [ Pubmed: 39818969 DOI: doi:10.1128/jvi.01533-24 ]
- Ectodomain of kshv glycoprotein b in postfusion form (230 kDa, Cellular component from Human gammaherpesvirus 8)
- Orf8 (66 kDa, Protein from Human gammaherpesvirus 8)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM micrographs of human DNA polymerase θ helicase domain bound to inhibitor AB25583
Ito F, Li Z, Minakhin L, Chandramouly G, Tyagi M, Betsch R, Krais JJ, Taberi B, Vekariya U, Calbert M, Skorski T, Johnson N, Chen XS, Pomerantz RT
Nat Commun (2024) 15 [ DOI: 10.1038/s41467-024-51351-4 Pubmed: 39143110 ]
Image sets:
Human DNA polymerase theta helicase domain in complex with inhibitor AB25583, dimer form
Ito F, Li Z, Minakhin L, Chandramouly G, Tyagi M, Betsch R, Krais JJ, Taberi B, Vekariya U, Calbert M, Skorski T, Johnson N, Chen XS, Pomerantz RT
Nat Commun (2024) 15 pp. 7003-7003 [ DOI: doi:10.1038/s41467-024-51351-4 Pubmed: 39143110 ]
Human DNA polymerase theta helicase domain in complex with inhibitor AB25583, tetramer form
Ito F, Li Z, Minakhin L, Chandramouly G, Tyagi M, Betsch R, Krais JJ, Taberi B, Vekariya U, Calbert M, Skorski T, Johnson N, Chen XS, Pomerantz RT
Nat Commun (2024) 15 pp. 7003-7003 [ DOI: doi:10.1038/s41467-024-51351-4 Pubmed: 39143110 ]
Human DNA polymerase theta helicase domain in complex with ssDNA, dimer form
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8w0a
Q-score: 0.435
Ito F, Li Z, Minakhin L, Khant HA, Pomerantz RT, Chen XS
bioRxiv (2024) [ DOI: doi:10.1101/2024.06.07.597860 Pubmed: 38895274 ]
- Human dna polymerase theta helicase domain in complex with ssdna (253 kDa, Complex from Homo sapiens)
- Dna (5'-d(p*tp*tp*tp*tp*tp*tp*t)-3') (13 kDa, DNA from Homo sapiens)
- Dna polymerase theta (99 kDa, Protein from Homo sapiens)
Human DNA polymerase theta helicase domain in complex with AMP-PNP, dimer form
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9asj
Q-score: 0.411
Ito F, Li Z, Minakhin L, Khant HA, Pomerantz RT, Chen XS
bioRxiv (2024) [ DOI: doi:10.1101/2024.06.07.597860 Pubmed: 38895274 ]
- Human dna polymerase theta helicase domain in complex with inhibitor amp-pnp (199 kDa, Complex from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Dna polymerase theta (99 kDa, Protein from Homo sapiens)
Human DNA polymerase theta helicase domain dimer, apo-form
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 9ask
Q-score: 0.389
Ito F, Li Z, Minakhin L, Khant HA, Pomerantz RT, Chen XS
bioRxiv (2024) [ DOI: doi:10.1101/2024.06.07.597860 Pubmed: 38895274 ]
- Human dna polymerase theta helicase domain dimer, apo-form (199 kDa, Complex from Homo sapiens)
- Dna polymerase theta (99 kDa, Protein from Homo sapiens)
Human DNA polymerase theta helicase domain tetramer, apo-form
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9asl
Q-score: 0.392
Ito F, Li Z, Minakhin L, Khant HA, Pomerantz RT, Chen XS
bioRxiv (2024) [ DOI: doi:10.1101/2024.06.07.597860 Pubmed: 38895274 ]
- Human dna polymerase theta helicase domain tetramer, apo-form (398 kDa, Complex from Homo sapiens)
- Dna polymerase theta (99 kDa, Protein from Homo sapiens)
Human DNA polymerase theta helicase domain in microhomology annealed state 1, dimer form
Ito F, Li Z, Minakhin L, Khant HA, Pomerantz RT, Chen XS
bioRxiv (2024) [ DOI: doi:10.1101/2024.06.07.597860 Pubmed: 38895274 ]