Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7fbs
Q-score: 0.477
Jiang D, Banh R, Gamal El-Din TM, Tonggu L, Lenaeus MJ, Pomes R, Zheng N, Catterall WA
Cell (2021) 184 pp. 5151- [ Pubmed: 34520724 DOI: doi:10.1016/j.cell.2021.08.021 ]
- Sodium channel with four homologous domains (250 kDa, Complex from Rattus norvegicus)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-[2-[(2r)-2-oxidanyl-3-(propylamino)propoxy]phenyl]-3-phenyl-propan-1-one (341 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,sodium channel protein type 5 subunit alpha,sodium channel protein type 5 subunit alpha,g protein/gfp fusion protein (209 kDa, Protein from Recombinant vesicular stomatitis Indiana virus rVSV-G/GFP)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Cardiac Sodium channel with toxin bound
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7k18
Q-score: 0.411
Jiang D, Tonggu L, Gamal El-Din TM, Banh R, Pomes R, Zheng N, Catterall WA
Nat Commun (2021) 12 pp. 128-128 [ DOI: doi:10.1038/s41467-020-20078-3 Pubmed: 33397917 ]
- Alpha-like toxin lqh3 (Complex from Leiurus hebraeus)
- Sodium channel protein type 5 subunit alpha, enhanced green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- Alpha-like toxin lqh3 (7 kDa, Protein from Leiurus hebraeus)
- Cryo-em map for sodium channel and scorpion toxin complex (250 kDa, Complex)
- Sodium channel protein type 5 subunit alpha (Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Cardiac sodium channel with flecainide
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 6uz0
Q-score: 0.459
Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Cell (2020) 180 pp. 122-134.e10 [ DOI: doi:10.1016/j.cell.2019.11.041 Pubmed: 31866066 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Flecainide (414 Da, Ligand)
- Cardiac sodium channel complex with flecainide (250 kDa, Complex from Rattus norvegicus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6uz3
Q-score: 0.401
Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Cell (2020) 180 pp. 122-134.e10 [ DOI: doi:10.1016/j.cell.2019.11.041 Pubmed: 31866066 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cardiac sodium channel apo structure (250 kDa, Complex from Rattus norvegicus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)