H176A mutant of human G6PC1 in complex with G6P
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 9j7u
Q-score: 0.551
Xia Z, Liu C, Wu D, Chen H, Zhao J, Jiang D
PNAS (2025) 122 pp. e2418316122-e2418316122 [ DOI: doi:10.1073/pnas.2418316122 Pubmed: 39847333 ]
- Glucose-6-phosphatase catalytic subunit 1 (39 kDa, Protein from Homo sapiens)
- 6-o-phosphono-beta-d-glucopyranose (260 Da, Ligand)
- Glucose-6-phosphatase catalytic subunit1 (Complex from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9j7v
Q-score: 0.527
Cryo-EM structures of human XPR1 in closed states
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8x5b
Q-score: 0.575
Yan R, Chen H, Liu C, Zhao J, Wu D, Jiang J, Gong J, Jiang D
Nature (2024) 633 pp. 960-967 [ DOI: doi:10.1038/s41586-024-07852-9 Pubmed: 39169184 ]
- Phosphate ion (94 Da, Ligand)
- Transport (Complex from Homo sapiens)
- Solute carrier family 53 member 1 (54 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Cryo-EM structure of human XPR1 in open state
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 8x5e
Q-score: 0.452
Yan R, Chen H, Liu C, Zhao J, Wu D, Jiang J, Gong J, Jiang D
Nature (2024) 633 pp. 960-967 [ DOI: doi:10.1038/s41586-024-07852-9 Pubmed: 39169184 ]
- Phosphate ion (94 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Transport (Complex from Homo sapiens)
- Solute carrier family 53 member 1 (54 kDa, Protein from Homo sapiens)
human XPR1 in complex with InsP6
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8x5f
Q-score: 0.511
Yan R, Chen H, Liu C, Zhao J, Wu D, Jiang J, Gong J, Jiang D
Nature (2024) 633 pp. 960-967 [ DOI: doi:10.1038/s41586-024-07852-9 Pubmed: 39169184 ]
- Phosphate ion (94 Da, Ligand)
- Transport (Complex from Homo sapiens)
- Solute carrier family 53 member 1 (81 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
VMAT2 complex with noradrenaline in lumen-facing state
Resolution: 3.16 Å
EM Method: Single-particle
Fitted PDBs: 8jsx
Q-score: 0.541
Wu D, Yu Z, Chen Q, Zhao J, Huang B, Wang Y, Su J, Li N, Jiang D, Zhao Y
Cell Res (2024) 34 pp. 586-589 [ DOI: doi:10.1038/s41422-024-00974-9 Pubmed: 38777861 ]
- Synaptic vesicular amine transporter (49 kDa, Protein from Homo sapiens)
- Noradrenaline (170 Da, Ligand)
- Transporterb (Complex from Homo sapiens)
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8jt5
Q-score: 0.521
Wu D, Yu Z, Chen Q, Zhao J, Huang B, Wang Y, Su J, Li N, Jiang D, Zhao Y
Cell Res (2024) 34 pp. 586-589 [ DOI: doi:10.1038/s41422-024-00974-9 Pubmed: 38777861 ]
- Synaptic vesicular amine transporter (49 kDa, Protein from Homo sapiens)
- Transporterc (Complex from Homo sapiens)
- Histamine (111 Da, Ligand)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8jtb
Q-score: 0.573
Wu D, Yu Z, Chen Q, Zhao J, Huang B, Wang Y, Su J, Li N, Jiang D, Zhao Y
Cell Res (2024) 34 pp. 586-589 [ DOI: doi:10.1038/s41422-024-00974-9 Pubmed: 38777861 ]
- Synaptic vesicular amine transporter (49 kDa, Protein from Homo sapiens)
- Transporterc (Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
