Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8j7f
Q-score: 0.555
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ Pubmed: 38693179 DOI: doi:10.1038/s41467-024-48125-3 ]
- Ile-ala-ala-ile-his-asn-ala-arg-arg-lys-lys-arg-glu-ala-ala-ala-ala-his-lys-ala (2 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Ion channel,voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment),ion transport domain-containing protein (33 kDa, Protein from Aequorea victoria)
- Ion channel complex (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8j7m
Q-score: 0.53
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ Pubmed: 38693179 DOI: doi:10.1038/s41467-024-48125-3 ]
- Ion channel (Complex from Homo sapiens)
- Ion channel,voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment) (90 kDa, Protein from Aequorea victoria)
- Cholesterol (386 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7xm9
Q-score: 0.449
Zhang J, Shi Y, Huang Z, Li Y, Yang B, Gong J, Jiang D
Nat Struct Mol Biol (2022) 29 pp. 1208-1216 [ Pubmed: 36424527 DOI: doi:10.1038/s41594-022-00860-1 ]
- Sodium channel complex (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-1,green fluorescent protein (54 kDa, Protein from Aequorea victoria)
- (7~{r})-1'-pentylspiro[6~{h}-furo[3,2-f][1,3]benzodioxole-7,3'-indole]-2'-one (351 Da, Ligand)
- Isoform 3 of sodium channel protein type 9 subunit alpha,green fluorescent protein (255 kDa, Protein from Aequorea victoria)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 7xmf
Q-score: 0.457
Zhang J, Shi Y, Huang Z, Li Y, Yang B, Gong J, Jiang D
Nat Struct Mol Biol (2022) 29 pp. 1208-1216 [ Pubmed: 36424527 DOI: doi:10.1038/s41594-022-00860-1 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-1,green fluorescent protein (54 kDa, Protein from Aequorea victoria)
- Sodium channel (Complex from Homo sapiens)
- Isoform 3 of sodium channel protein type 9 subunit alpha,green fluorescent protein (255 kDa, Protein from Aequorea victoria)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- 3-[[4-[3-(4-fluoranyl-2-methyl-phenoxy)azetidin-1-yl]pyrimidin-2-yl]amino]-~{n}-methyl-benzamide (407 Da, Ligand)
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 7xmg
Q-score: 0.436
Zhang J, Shi Y, Huang Z, Li Y, Yang B, Gong J, Jiang D
Nat Struct Mol Biol (2022) 29 pp. 1208-1216 [ Pubmed: 36424527 DOI: doi:10.1038/s41594-022-00860-1 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-1,green fluorescent protein (54 kDa, Protein from Aequorea victoria)
- Sodium channel (Complex from Homo sapiens)
- Isoform 3 of sodium channel protein type 9 subunit alpha,green fluorescent protein (255 kDa, Protein from Aequorea victoria)
- Sodium channel subunit beta-2 (24 kDa, Protein from Homo sapiens)
- (1~{z})-~{n}-[2-methyl-3-[(~{e})-[6-[4-[[4-(trifluoromethyloxy)phenyl]methoxy]piperidin-1-yl]-1~{h}-1,3,5-triazin-2-ylidene]amino]phenyl]ethanimidic acid (516 Da, Ligand)
Cardiac Sodium channel with toxin bound
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7k18
Q-score: 0.411
Jiang D, Tonggu L, Gamal El-Din TM, Banh R, Pomes R, Zheng N, Catterall WA
Nat Commun (2021) 12 pp. 128-128 [ Pubmed: 33397917 DOI: doi:10.1038/s41467-020-20078-3 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel protein type 5 subunit alpha, enhanced green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- Sodium channel protein type 5 subunit alpha (Complex from Rattus norvegicus)
- Cryo-em map for sodium channel and scorpion toxin complex (250 kDa, Complex)
- Alpha-like toxin lqh3 (Complex from Leiurus hebraeus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
- Alpha-like toxin lqh3 (7 kDa, Protein from Leiurus hebraeus)
Cardiac sodium channel with flecainide
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 6uz0
Q-score: 0.459
Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Cell (2020) 180 pp. 122-134.e10 [ Pubmed: 31866066 DOI: doi:10.1016/j.cell.2019.11.041 ]
- Cardiac sodium channel complex with flecainide (250 kDa, Complex from Rattus norvegicus)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Flecainide (414 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6uz3
Q-score: 0.401
Jiang D, Shi H, Tonggu L, Gamal El-Din TM, Lenaeus MJ, Zhao Y, Yoshioka C, Zheng N, Catterall WA
Cell (2020) 180 pp. 122-134.e10 [ Pubmed: 31866066 DOI: doi:10.1016/j.cell.2019.11.041 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel protein type 5 subunit alpha,green fluorescent protein (209 kDa, Protein from Aequorea victoria)
- Cardiac sodium channel apo structure (250 kDa, Complex from Rattus norvegicus)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)