RMC-5552 in complex with mTORC1 and FKBP12
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8era
Q-score: 0.42
Burnett GL, Yang YC, Aggen JB, Pitzen J, Gliedt MK, Semko CM, Marquez A, Evans JW, Wang G, Won WS, Tomlinson ACA, Kiss G, Tzitzilonis C, Thottumkara AP, Cregg J, Mellem KT, Choi JS, Lee JC, Zhao Y, Lee BJ, Meyerowitz JG, Knox JE, Jiang J, Wang Z, Wildes D, Wang Z, Singh M, Smith JAM, Gill AL
J Med Chem (2023) 66 pp. 149-169 [ DOI: doi:10.1021/acs.jmedchem.2c01658 Pubmed: 36533617 ]
- Serine/threonine-protein kinase mtor (289 kDa, Protein from Homo sapiens)
- (3s,5r,6r,7e,9r,10r,12r,14s,15e,17e,19e,21s,23s,26r,27r,30r,34as)-5,9,27-trihydroxy-3-{(2r)-1-[(1s,3r,4r)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3h-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4h,31h)-tetrone (916 Da, Ligand)
- Target of rapamycin complex subunit lst8 (35 kDa, Protein from Homo sapiens)
- 1-[6-{[(3m)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1h)-yl]-3-hydroxypropan-1-one (484 Da, Ligand)
- Regulatory-associated protein of mtor (149 kDa, Protein from Homo sapiens)
- Rmc-5552-mtorc1-fkbp12 (Complex from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Homo sapiens)
Cryo-EM structure of the N-terminal alpha-synuclein truncation 41-140
Resolution: 3.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 7lc9
Q-score: 0.498
McGlinchey RP, Ni X, Shadish JA, Jiang J, Lee JC
PNAS (2021) 118 [ Pubmed: 34452994 DOI: doi:10.1073/pnas.2023487118 ]
- N-terminal alpha-synuclein truncation 41-140 (Complex from Homo sapiens)
- Alpha-synuclein (10 kDa, Protein from Homo sapiens)
Cryo-EM structure of the N-terminally acetylated full length alpha-synuclein fibrils (Ac1-140)
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 6osj
Q-score: 0.578
Ni X, McGlinchey RP, Jiang J, Lee JC
J Mol Biol (2019) 431 pp. 3913-3919 [ DOI: doi:10.1016/j.jmb.2019.07.001 Pubmed: 31295458 ]
Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-122
Resolution: 3.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 6osl
Q-score: 0.557
Ni X, McGlinchey RP, Jiang J, Lee JC
J Mol Biol (2019) 431 pp. 3913-3919 [ DOI: doi:10.1016/j.jmb.2019.07.001 Pubmed: 31295458 ]
Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-103
Resolution: 3.4 Å
EM Method: Helical reconstruction
Fitted PDBs: 6osm
Q-score: 0.504
Ni X, McGlinchey RP, Jiang J, Lee JC
J Mol Biol (2019) 431 pp. 3913-3919 [ DOI: doi:10.1016/j.jmb.2019.07.001 Pubmed: 31295458 ]