Cryo-EM structure of cystinosin in a cytosol-open state
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8dke
Q-score: 0.532
Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X
Cell (2022) 185 pp. 3739-3752.e18 [ Pubmed: 36113465 DOI: doi:10.1016/j.cell.2022.08.020 ]
- Fab 3h5 kappa chain (25 kDa, Protein from Mus musculus)
- Cystinosin-fab 3h5 complex in cytosol-open conformation (Complex)
- Isoform 2 of cystinosin (46 kDa, Protein from Homo sapiens)
- Fab 3h5 heavy chain (26 kDa, Protein from Mus musculus)
- Fab 3h5 (Complex from Mus musculus)
- Cystinosin (Complex from Homo sapiens)
Cryo-EM structure of cystinosin in a lumen-open state
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8dki
Q-score: 0.497
Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X
Cell (2022) 185 pp. 3739-3752.e18 [ Pubmed: 36113465 DOI: doi:10.1016/j.cell.2022.08.020 ]
- Cystinosin-fab 3h5 complex in lumen-open conformation (Complex)
- Fab 3h5 heavy chain (26 kDa, Protein from Mus musculus)
- Fab 3h5 kappa chain (25 kDa, Protein from Mus musculus)
- Isoform 2 of cystinosin (46 kDa, Protein from Homo sapiens)
- Fab 3h5 (Complex from Mus musculus)
- Cystinosin (Complex from Homo sapiens)
Cryo-EM structure of cystine-bound cystinosin in a lumen-open state
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8dkm
Q-score: 0.51
Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X
Cell (2022) 185 pp. 3739-3752.e18 [ Pubmed: 36113465 DOI: doi:10.1016/j.cell.2022.08.020 ]
- Fab 3h5 kappa chain (25 kDa, Protein from Mus musculus)
- Fab 3h5 heavy chain (26 kDa, Protein from Mus musculus)
- Isoform 2 of cystinosin (46 kDa, Protein from Homo sapiens)
- Fab 3h5 (Complex from Mus musculus)
- L-cystine (240 Da, Ligand)
- Cystinosin (Complex from Homo sapiens)
- Cystinosin-fab 3h5 complex with cystine bound in a lumen-open conformation (Complex from Homo sapiens)
Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH5.0
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8dkw
Q-score: 0.522
Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X
Cell (2022) 185 pp. 3739-3752.e18 [ Pubmed: 36113465 DOI: doi:10.1016/j.cell.2022.08.020 ]
- Fab 3h5 heavy chain (26 kDa, Protein from Mus musculus)
- Isoform 2 of cystinosin (46 kDa, Protein from Homo sapiens)
- Cystinosin n288k - fab 3h5 complex at ph5.0 (Complex)
- Cystinosin n288k (Complex from Homo sapiens)
- Fab 3h5 (Complex from Mus musculus)
- Fab 3h5 kappa chain (25 kDa, Protein from Mus musculus)
Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH7.5
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8dkx
Q-score: 0.542
Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X
Cell (2022) 185 pp. 3739-3752.e18 [ Pubmed: 36113465 DOI: doi:10.1016/j.cell.2022.08.020 ]
- Fab 3h5 heavy chain (26 kDa, Protein from Mus musculus)
- Isoform 2 of cystinosin (46 kDa, Protein from Homo sapiens)
- Cystinosin n288k - fab 3h5 complex at ph7.5 (Complex)
- Cystinosin n288k (Complex from Homo sapiens)
- Fab 3h5 (Complex from Mus musculus)
- Fab 3h5 kappa chain (25 kDa, Protein from Mus musculus)