Cryo-EM structure of the DMCHA-bound mTAAR9-Gs complex
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8itf
Q-score: 0.491
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- ~{n},~{n}-dimethylcyclohexanamine (127 Da, Ligand)
- Cryo-em structure of the dmcha-bound mtaar9-gs complex (Complex from Mus musculus)
Cryo-EM structure of the PEA-bound mTAAR9-Golf complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8iw1
Q-score: 0.436
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- Scfv16 (30 kDa, Protein from synthetic construct)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(olf) subunit alpha (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of the pea-bound mtaar9-golf complex (Complex from Mus musculus)
Cryo-EM structure of the SPE-bound mTAAR9-Gs complex
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 8iw4
Q-score: 0.508
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- Scfv16 (30 kDa, Protein from synthetic construct)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Spermidine (145 Da, Ligand)
- Cryo-em structure of the spe-bound mtaar9-gs complex (Complex from Mus musculus)
Cryo-EM structure of the PEA-bound mTAAR9-Gs complex
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8iw7
Q-score: 0.518
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- Cryo-em structure of the pea-bound mtaar9-gs complex (Complex from Mus musculus)
- Scfv16 (30 kDa, Protein from Escherichia coli BL21(DE3))
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- 2-phenylethylamine (122 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
Cryo-EM structure of the CAD-bound mTAAR9-Gs complex
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8iw9
Q-score: 0.546
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- Scfv16 (30 kDa, Protein from synthetic construct)
- Cryo-em structure of the cad-bound mtaar9-gs complex (Complex from Mus musculus)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
Cryo-EM structure of the SPE-mTAAR9 complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8iwe
Q-score: 0.493
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- Cryo-em structure of the spe-bound mtaar9 complex (Complex from Mus musculus)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- Spermidine (145 Da, Ligand)
Cryo-EM structure of the PEA-bound mTAAR9 complex
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8iwm
Q-score: 0.491
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- Cryo-em structure of the pea-bound mtaar9 complex (Complex from Mus musculus)
- 2-phenylethylamine (122 Da, Ligand)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
Cryo-EM structure of human TMEM120A in the CoASH-bound state
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 7f3t
Q-score: 0.443
Rong Y, Jiang J, Gao Y, Guo J, Song D, Liu W, Zhang M, Zhao Y, Xiao B, Liu Z
eLife (2021) 10 [ Pubmed: 34409941 DOI: doi:10.7554/eLife.71474 ]
- Coenzyme a (767 Da, Ligand)
- Transmembrane protein 120a (44 kDa, Protein from Homo sapiens)
- Transmembrane protein 120a (Cell from Homo sapiens)
Cryo-EM structure of human TMEM120A in the CoASH-free state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7f3u
Q-score: 0.335
Rong Y, Jiang J, Gao Y, Guo J, Song D, Liu W, Zhang M, Zhao Y, Xiao B, Liu Z
eLife (2021) 10 [ Pubmed: 34409941 DOI: doi:10.7554/eLife.71474 ]
- Transmembrane protein 120a (44 kDa, Protein from Homo sapiens)
- Transmembrane protein 120a (Cell from Homo sapiens)