Cryo-EM structures of human XPR1 in closed states
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8x5b
Q-score: 0.575
Yan R, Chen H, Liu C, Zhao J, Wu D, Jiang J, Gong J, Jiang D
Nature (2024) 633 pp. 960-967 [ DOI: doi:10.1038/s41586-024-07852-9 Pubmed: 39169184 ]
- Cholesterol (386 Da, Ligand)
- Water (18 Da, Ligand)
- Solute carrier family 53 member 1 (54 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transport (Complex from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
Cryo-EM structure of human XPR1 in open state
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 8x5e
Q-score: 0.452
Yan R, Chen H, Liu C, Zhao J, Wu D, Jiang J, Gong J, Jiang D
Nature (2024) 633 pp. 960-967 [ DOI: doi:10.1038/s41586-024-07852-9 Pubmed: 39169184 ]
- Solute carrier family 53 member 1 (54 kDa, Protein from Homo sapiens)
- Transport (Complex from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- [(2~{r})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{z})-octadec-9-enoate (717 Da, Ligand)
human XPR1 in complex with InsP6
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8x5f
Q-score: 0.511
Yan R, Chen H, Liu C, Zhao J, Wu D, Jiang J, Gong J, Jiang D
Nature (2024) 633 pp. 960-967 [ DOI: doi:10.1038/s41586-024-07852-9 Pubmed: 39169184 ]
- Cholesterol (386 Da, Ligand)
- Water (18 Da, Ligand)
- Solute carrier family 53 member 1 (81 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Transport (Complex from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8j7f
Q-score: 0.555
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ DOI: doi:10.1038/s41467-024-48125-3 Pubmed: 38693179 ]
- Ile-ala-ala-ile-his-asn-ala-arg-arg-lys-lys-arg-glu-ala-ala-ala-ala-his-lys-ala (2 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Water (18 Da, Ligand)
- Ion channel complex (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Ion channel,voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment),ion transport domain-containing protein (33 kDa, Protein from Aequorea victoria)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8j7m
Q-score: 0.53
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ DOI: doi:10.1038/s41467-024-48125-3 Pubmed: 38693179 ]
- Ion channel (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Ion channel,voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment),voltage dependent ion channel,green fluorescent protein (fragment) (90 kDa, Protein from Aequorea victoria)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8j7h
Q-score: 0.448
Chen H, Xia Z, Dong J, Huang B, Zhang J, Zhou F, Yan R, Shi Y, Gong J, Jiang J, Huang Z, Jiang D
Nat Commun (2024) 15 pp. 3691-3691 [ DOI: doi:10.1038/s41467-024-48125-3 Pubmed: 38693179 ]
- Water (18 Da, Ligand)
- Ile-ala-ala-ile-his-asn-ala-arg-arg-lys-lys-arg-glu-ala-ala-ala-ala-his-lys-ala (2 kDa, Protein from Homo sapiens)
- Ion channel (91 kDa, Protein from Homo sapiens)
- Ion channel complex (Complex from Homo sapiens)
Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with glutamate
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7xr4
Q-score: 0.532
Zhang Z, Chen H, Geng Z, Yu Z, Li H, Dong Y, Zhang H, Huang Z, Jiang J, Zhao Y
Nat Commun (2022) 13 pp. 3329-3329 [ DOI: doi:10.1038/s41467-022-31031-x Pubmed: 35680945 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transporter (Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Excitatory amino acid transporter 2 (62 kDa, Protein from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with WAY-213613
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7xr6
Q-score: 0.511
Zhang Z, Chen H, Geng Z, Yu Z, Li H, Dong Y, Zhang H, Huang Z, Jiang J, Zhao Y
Nat Commun (2022) 13 pp. 3329-3329 [ DOI: doi:10.1038/s41467-022-31031-x Pubmed: 35680945 ]
- Excitatory amino acid transporter 2 (62 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transporter (Complex from Homo sapiens)
- (2s)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid (415 Da, Ligand)
- Dodecyl beta-d-glucopyranoside (348 Da, Ligand)
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7x5v
Q-score: 0.518
Zhang J, Shi Y, Fan J, Chen H, Xia Z, Huang B, Jiang J, Gong J, Huang Z, Jiang D
Nat Commun (2022) 13 pp. 2713-2713 [ Pubmed: 35581266 DOI: doi:10.1038/s41467-022-30400-w ]
- Ion channel (1 kDa, Protein from Emiliania huxleyi)
- Ion channel complex (Complex from Emiliania huxleyi)
- Ion channel,gfp-twinstrep (91 kDa, Protein from Emiliania huxleyi)