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primary_citation_author:"Jiao HZ"
Cryo-EM strucutre of CXCR4 complexed with antagonist HF51116
Release date: Feb. 26, 2025
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8zpl
Q-score: 0.516
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8zpl
Q-score: 0.516
Sang XH, Jiao HZ, Huang ZW, Hu HL
To Be Published
Sample:
- (2s)-n-[[4-[[3-(cyclohexylamino)propylamino]methyl]phenyl]methyl]-5-(diaminomethylideneamino)-2-(pyridin-2-ylmethylamino)pentanamide (522 Da, Ligand)
- Hf51116-cxcr4-kor-nb6 (Complex from Homo sapiens)
- Soluble cytochrome b562,c-x-c chemokine receptor type 4 (55 kDa, Protein from Homo sapiens)
- Nb6 nanobody (18 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
Cryo-EM strucutre of CXCR4 complexed with antagonist AMD070
Release date: Feb. 26, 2025
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8zpm
Q-score: 0.476
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8zpm
Q-score: 0.476
Sang XH, Jiao HZ, Huang ZW, Hu HL
To Be Published
Sample:
- Amd070-cxcr4-kor-nb6 (Complex from Homo sapiens)
- Soluble cytochrome b562,c-x-c chemokine receptor type 4 (55 kDa, Protein from Homo sapiens)
- Nb6 nanobody (18 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- (s)-n1-((1h-benzo[d]imidazol-2-yl)methyl)-n1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine (349 Da, Ligand)
Cryo-EM strucutre of CXCR4 complexed with antagonist AMD3100
Release date: Feb. 26, 2025
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8zpn
Q-score: 0.458
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8zpn
Q-score: 0.458
Sang XH, Jiao HZ, Huang ZW, Hu HL
To Be Published
Sample:
- Plerixafor (502 Da, Ligand)
- Soluble cytochrome b562,c-x-c chemokine receptor type 4 (55 kDa, Protein from Homo sapiens)
- Nb6 nanobody (18 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- Amd3100-cxcr4-kor-nb6 (Complex from Homo sapiens)