T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor CT1
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8gcc
Q-score: 0.574
Rao SPS, Gould MK, Noeske J, Saldivia M, Jumani RS, Ng PS, Rene O, Chen YL, Kaiser M, Ritchie R, Francisco AF, Johnson N, Patra D, Cheung H, Deniston C, Schenk AD, Cortopassi WA, Schmidt RS, Wiedemar N, Thomas B, Palkar R, Ghafar NA, Manoharan V, Luu C, Gable JE, Wan KF, Myburgh E, Mottram JC, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly JM, Manjunatha UH, Maeser P, Jiricek J, Lakshminarayana SB, Barrett MP, Diagana TT
Science (2023) 380 pp. 1349-1356 [ Pubmed: 37384702 DOI: doi:10.1126/science.adh0614 ]
- Dsdna (Complex from Escherichia coli)
- Dna (28-mer) (8 kDa, DNA from Escherichia coli)
- Topoisomerase ii alpha bound to dsdna and inhibitor ct1 (Complex from Trypanosoma cruzi)
- Topoisomerase ii alpha (Complex from Trypanosoma cruzi)
- 2-{3-[(z)-iminomethyl]-1h-1,2,4-triazol-1-yl}-1-{(3m)-3-[2-(trifluoromethyl)phenyl]-6h-pyrrolo[3,4-b]pyridin-6-yl}ethan-1-one (398 Da, Ligand)
- Dna topoisomerase 2 (89 kDa, Protein from Trypanosoma cruzi strain CL Brener)
Leishmania tarentolae proteasome 20S subunit in complex with compound 2
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7zyj
Q-score: 0.565
Koester DC, Marx VM, Williams S, Jiricek J, Dauphinais M, Rene O, Miller SL, Zhang L, Patra D, Chen YL, Cheung H, Gable J, Lakshminarayana SB, Osborne C, Galarneau JR, Kulkarni U, Richmond W, Bretz A, Xiao L, Supek F, Wiesmann C, Honnappa S, Be C, Maser P, Kaiser M, Ritchie R, Barrett MP, Diagana TT, Sarko C, Rao SPS
J Med Chem (2022) 65 pp. 11776-11787 [ DOI: doi:10.1021/acs.jmedchem.2c00791 Pubmed: 35993839 ]
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (22 kDa, Protein from Leishmania tarentolae)
- Proteasome alpha 7 subunit, putative (25 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (24 kDa, Protein from Leishmania tarentolae)
- ~{n}-cyclopentyl-6-methyl-4-phenylazanyl-quinoline-2-carboxamide (345 Da, Ligand)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania tarentolae)
- Proteasome alpha 1 subunit, putative (47 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (23 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit beta (22 kDa, Protein from Leishmania tarentolae)
- Proteasome beta 6 subunit, putative (37 kDa, Protein from Leishmania tarentolae)
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania tarentolae)
- Proteasome alpha 5 subunit, putative (38 kDa, Protein from Leishmania tarentolae)
- Proteasome (840 kDa, Complex from Leishmania tarentolae)
Leishmania tarentolae proteasome 20S subunit complexed with LXE408
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6tcz
Q-score: 0.514
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus B, Kreishman-Deitrick M, Bursulaya B, Lai YH, Gao MY, Liang F, Mathison CJN, Liu X, Yeh V, Smith J, Lerario I, Xie Y, Chianelli D, Gibney M, Berman A, Chen YL, Jiricek J, Davis LC, Liu X, Ballard J, Khare S, Eggimann FK, Luneau A, Groessl T, Shapiro M, Richmond W, Johnson K, Rudewicz PJ, Rao SPS, Thompson C, Tuntland T, Spraggon G, Glynne RJ, Supek F, Wiesmann C, Molteni V
J Med Chem (2020) 63 pp. 10773-10781 [ Pubmed: 32667203 DOI: doi:10.1021/acs.jmedchem.0c00499 ]
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (47 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (38 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (37 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (30 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (27 kDa, Protein from Leishmania donovani)
- ~{n}-[4-fluoranyl-3-[6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide (443 Da, Ligand)
- Proteasome subunit beta (33 kDa, Protein from Leishmania donovani)
- Proteasome subunit family protein (23 kDa, Protein from Leishmania donovani)
- Leishmania tarentolae proteasome 20s subunit complex (Complex from Leishmania donovani)
Leishmania tarentolae proteasome 20S subunit complexed with LXE408 and bortezomib
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 6td5
Q-score: 0.512
Nagle A, Biggart A, Be C, Srinivas H, Hein A, Caridha D, Sciotti RJ, Pybus B, Kreishman-Deitrick M, Bursulaya B, Lai YH, Gao MY, Liang F, Mathison CJN, Liu X, Yeh V, Smith J, Lerario I, Xie Y, Chianelli D, Gibney M, Berman A, Chen YL, Jiricek J, Davis LC, Liu X, Ballard J, Khare S, Eggimann FK, Luneau A, Groessl T, Shapiro M, Richmond W, Johnson K, Rudewicz PJ, Rao SPS, Thompson C, Tuntland T, Spraggon G, Glynne RJ, Supek F, Wiesmann C, Molteni V
J Med Chem (2020) 63 pp. 10773-10781 [ Pubmed: 32667203 DOI: doi:10.1021/acs.jmedchem.0c00499 ]
- Proteasome subunit alpha type (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (47 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (25 kDa, Protein from Leishmania donovani)
- ~{n}-[4-fluoranyl-3-[6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]phenyl]-2,4-dimethyl-1,3-oxazole-5-carboxamide (443 Da, Ligand)
- Proteasome subunit alpha type (38 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- N-[(1r)-1-(dihydroxyboryl)-3-methylbutyl]-n-(pyrazin-2-ylcarbonyl)-l-phenylalaninamide (384 Da, Ligand)
- Leishmania tarentolae proteasome 20s subunit complexed with lxe408 and bortezomib (Complex from Leishmania donovani)
- Proteasome subunit alpha type (25 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (22 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (37 kDa, Protein from Leishmania donovani)
- Proteasome endopeptidase complex (27 kDa, Protein from Leishmania donovani)
- Proteasome subunit beta (24 kDa, Protein from Leishmania donovani)
- Proteasome subunit alpha type (32 kDa, Protein from Leishmania donovani)
- Proteasome subunit family protein (23 kDa, Protein from Leishmania donovani)