Cryo-EM structure of the GR-Hsp90-FKBP52 complex
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8ffv
Q-score: 0.4
Noddings CM, Johnson JL, Agard DA
Nat Struct Mol Biol (2023) 30 pp. 1867-1877 [ DOI: doi:10.1038/s41594-023-01128-y Pubmed: 37945740 ]
- Peptidyl-prolyl cis-trans isomerase fkbp4, n-terminally processed (51 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Glucocorticoid receptor (41 kDa, Protein from Homo sapiens)
- Heat shock protein hsp 90-alpha (84 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Complex of the glucocorticoid receptor ligand binding domain, hsp90 alpha dimer, and the co-chaperone fkbp52 (307 kDa, Complex from Homo sapiens)
- Dexamethasone (392 Da, Ligand)
Cryo-EM structure of the GR-Hsp90-FKBP51 complex
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8ffw
Q-score: 0.369
Noddings CM, Johnson JL, Agard DA
Nat Struct Mol Biol (2023) 30 pp. 1867-1877 [ Pubmed: 37945740 DOI: doi:10.1038/s41594-023-01128-y ]
- Complex of the glucocorticoid receptor ligand binding domain, hsp90 alpha dimer, and the co-chaperone fkbp51 (306 kDa, Complex from Homo sapiens)
- Heat shock protein hsp 90-alpha (84 kDa, Protein from Homo sapiens)
- Dexamethasone (392 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Glucocorticoid receptor (41 kDa, Protein from Homo sapiens)
- Peptidyl-prolyl cis-trans isomerase fkbp5 (51 kDa, Protein from Homo sapiens)
Noddings CM, Wang RY, Johnson JL, Agard DA
Nature (2021) 601 pp. 465-469 [ Pubmed: 34937936 DOI: 10.1038/s41586-021-04236-1 ]
Image sets:
The GR-Maturation Complex: Glucocorticoid Receptor in complex with Hsp90 and co-chaperone p23
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 7krj
Q-score: 0.539
Noddings CM, Wang RY, Johnson JL, Agard DA
Nature (2021) 601 pp. 465-469 [ DOI: doi:10.1038/s41586-021-04236-1 Pubmed: 34937936 ]
- Dexamethasone (392 Da, Ligand)
- Complex of the glucocorticoid receptor ligand binding domain, hsp90 alpha dimer, and the co-chaperone p23 (263 kDa, Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Glucocorticoid receptor (29 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Heat shock protein hsp 90-alpha (84 kDa, Protein from Homo sapiens)
- Prostaglandin e synthase 3 (18 kDa, Protein from Homo sapiens)
Maltose Binding Protein in complex with Hsp90 and co-chaperone p23
Noddings CM, Wang RY, Johnson JL, Agard DA
Nature (2021) 601 pp. 465-469 [ DOI: doi:10.1038/s41586-021-04236-1 Pubmed: 34937936 ]
- Heat shock protein 90 (Protein from Homo sapiens)
- Complex of the maltose binding protein, hsp90 dimer, and the co-chaperone p23 (263 kDa, Complex from Homo sapiens)
- P23 (Protein from Homo sapiens)
- Maltose binding protein (Protein from Homo sapiens)
Complex of Hsp90 and co-chaperone p23
Noddings CM, Wang RY, Johnson JL, Agard DA
Nature (2021) 601 pp. 465-469 [ DOI: doi:10.1038/s41586-021-04236-1 Pubmed: 34937936 ]
- Heat shock protein 90 (Protein from Homo sapiens)
- Complex of hsp90 dimer and the co-chaperone p23 (188 kDa, Complex from Homo sapiens)
- P23 (Protein from Homo sapiens)
Atomic cryoEM structure of Hsp90-Hsp70-Hop-GR
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 7kw7
Q-score: 0.276
Wang RY, Noddings CM, Kirschke E, Myasnikov AG, Johnson JL, Agard DA
Nature (2022) 601 pp. 460-464 [ Pubmed: 34937942 DOI: doi:10.1038/s41586-021-04252-1 ]
- Heat shock 70 kda protein 1a (Complex from Homo sapiens)
- Heat shock 70 kda protein 1a (70 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Hsp90-hsp70-hop-gr complex (Complex)
- Potassium ion (39 Da, Ligand)
- Heat shock protein hsp 90-alpha (Complex from Homo sapiens)
- Stress-induced-phosphoprotein 1 (62 kDa, Protein from Homo sapiens)
- Stress-induced-phosphoprotein 1 (Complex from Homo sapiens)
- Heat shock protein hsp 90-alpha (84 kDa, Protein from Homo sapiens)
- Glucocorticoid receptor (85 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Glucocorticoid receptor (Complex from Homo sapiens)
Focused map of the Hsp90-Hsp70-Hop-GR client-loading complex: Hsp90-CTDs:Hop-DP2:GR-Helix1
Wang RY, Noddings CM, Kirschke E, Myasnikov AG, Johnson JL, Agard DA
Nature (2022) 601 pp. 460-464 [ Pubmed: 34937942 DOI: doi:10.1038/s41586-021-04252-1 ]
Focused map of the Hsp90-Hsp70-Hop-GR complex: Hsp90A-NTD-MD:Hsp70C-NBD
Wang RY, Noddings CM, Kirschke E, Myasnikov AG, Johnson JL, Agard DA
Nature (2022) 601 pp. 460-464 [ Pubmed: 34937942 DOI: doi:10.1038/s41586-021-04252-1 ]
Focused map of the Hsp90-Hsp70-Hop-GR complex: Hsp90B-NTD-MD:Hsp70D-NBD
Wang RY, Noddings CM, Kirschke E, Myasnikov AG, Johnson JL, Agard DA
Nature (2022) 601 pp. 460-464 [ Pubmed: 34937942 DOI: doi:10.1038/s41586-021-04252-1 ]