Structure of the TSC:WIPI3 lysosomal recruitment complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9ce3
Q-score: 0.382
Bayly-Jones C, Lupton CJ, D'Andrea L, Chang YG, Jones GD, Steele JR, Venugopal H, Schittenhelm RB, Halls ML, Ellisdon AM
Sci Adv (2024) 10 pp. eadr5807-eadr5807 [ Pubmed: 39565846 DOI: doi:10.1126/sciadv.adr5807 ]
- Isoform 4 of tuberin (199 kDa, Protein from Homo sapiens)
- Tsc:wipi3 lysosomal recruitment complex (composite map) (733 kDa, Complex from Homo sapiens)
- Wd repeat domain phosphoinositide-interacting protein 3 (35 kDa, Protein from Homo sapiens)
- Unknown fragment (1 kDa, Protein from Homo sapiens)
- Hamartin (133 kDa, Protein from Homo sapiens)
- Tbc1 domain family member 7 (35 kDa, Protein from Homo sapiens)
The WIPI3:TSC lysosomal docking complex (consensus reconstruction)
Bayly-Jones C, Lupton CJ, D'Andrea L, Chang YG, Jones GD, Steele JR, Venugopal H, Schittenhelm RB, Halls ML, Ellisdon AM
Sci Adv (2024) 10 pp. eadr5807-eadr5807 [ Pubmed: 39565846 DOI: doi:10.1126/sciadv.adr5807 ]
- Tsc:wipi3 lysosomal recruitment complex (733 kDa, Complex from Homo sapiens)
The WIPI3:TSC lysosomal docking complex (focused reconstruction; core)
Bayly-Jones C, Lupton CJ, D'Andrea L, Chang YG, Jones GD, Steele JR, Venugopal H, Schittenhelm RB, Halls ML, Ellisdon AM
Sci Adv (2024) 10 pp. eadr5807-eadr5807 [ Pubmed: 39565846 DOI: doi:10.1126/sciadv.adr5807 ]
- Tsc:wipi3 lysosomal recruitment complex (733 kDa, Complex from Homo sapiens)
The WIPI3:TSC lysosomal docking complex (focused reconstruction; TSC1 N-terminus)
Bayly-Jones C, Lupton CJ, D'Andrea L, Chang YG, Jones GD, Steele JR, Venugopal H, Schittenhelm RB, Halls ML, Ellisdon AM
Sci Adv (2024) 10 pp. eadr5807-eadr5807 [ Pubmed: 39565846 DOI: doi:10.1126/sciadv.adr5807 ]
- Tsc:wipi3 lysosomal recruitment complex (733 kDa, Complex from Homo sapiens)
The WIPI3:TSC lysosomal docking complex (focused reconstruction; TBC1D7)
Bayly-Jones C, Lupton CJ, D'Andrea L, Chang YG, Jones GD, Steele JR, Venugopal H, Schittenhelm RB, Halls ML, Ellisdon AM
Sci Adv (2024) 10 pp. eadr5807-eadr5807 [ Pubmed: 39565846 DOI: doi:10.1126/sciadv.adr5807 ]
- Tsc:wipi3 lysosomal recruitment complex (733 kDa, Complex from Homo sapiens)
The WIPI3:TSC lysosomal docking complex (focused reconstruction; TBC1D7/TSC2)
Bayly-Jones C, Lupton CJ, D'Andrea L, Chang YG, Jones GD, Steele JR, Venugopal H, Schittenhelm RB, Halls ML, Ellisdon AM
Sci Adv (2024) 10 pp. eadr5807-eadr5807 [ Pubmed: 39565846 DOI: doi:10.1126/sciadv.adr5807 ]
- Tsc:wipi3 lysosomal recruitment complex (733 kDa, Complex from Homo sapiens)
The WIPI3:TSC lysosomal docking complex (focused reconstruction; WIPI3)
Bayly-Jones C, Lupton CJ, D'Andrea L, Chang YG, Jones GD, Steele JR, Venugopal H, Schittenhelm RB, Halls ML, Ellisdon AM
Sci Adv (2024) 10 pp. eadr5807-eadr5807 [ Pubmed: 39565846 DOI: doi:10.1126/sciadv.adr5807 ]
- Tsc:wipi3 lysosomal recruitment complex (733 kDa, Complex from Homo sapiens)
The WIPI3:TSC lysosomal docking complex (focused reconstruction; WIPI3 TSC2)
Bayly-Jones C, Lupton CJ, D'Andrea L, Chang YG, Jones GD, Steele JR, Venugopal H, Schittenhelm RB, Halls ML, Ellisdon AM
Sci Adv (2024) 10 pp. eadr5807-eadr5807 [ Pubmed: 39565846 DOI: doi:10.1126/sciadv.adr5807 ]
- Tsc:wipi3 lysosomal recruitment complex (733 kDa, Complex from Homo sapiens)
The mTORC1 cholesterol sensor LYCHOS (GPR155)
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8u54
Q-score: 0.293
Bayly-Jones C, Lupton CJ, Keen AC, Dong S, Mastos C, Luo W, Qian C, Jones GD, Venugopal H, Chang YG, Clarke RJ, Halls ML, Ellisdon AM
Nature (2024) 634 pp. 1238-1244 [ Pubmed: 39358511 DOI: doi:10.1038/s41586-024-08012-9 ]
- Homodimeric complex of lychos (gpr155) (198 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Integral membrane protein gpr155 (99 kDa, Protein from Homo sapiens)
The mTORC1 cholesterol sensor LYCHOS (GPR155)
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8u56
Q-score: 0.448
Bayly-Jones C, Lupton CJ, Keen AC, Dong S, Mastos C, Luo W, Qian C, Jones GD, Venugopal H, Chang YG, Clarke RJ, Halls ML, Ellisdon AM
Nature (2024) 634 pp. 1238-1244 [ Pubmed: 39358511 DOI: doi:10.1038/s41586-024-08012-9 ]
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Integral membrane protein gpr155 (99 kDa, Protein from Homo sapiens)
- Homodimeric complex of lychos (gpr155) - transmembrane region (198 kDa, Complex from Homo sapiens)