The mTORC1 cholesterol sensor LYCHOS (GPR155)
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8u54
Q-score: 0.293
Bayly-Jones C, Lupton CJ, Keen AC, Dong S, Mastos C, Luo W, Qian C, Jones GD, Venugopal H, Chang YG, Clarke RJ, Halls ML, Ellisdon AM
Nature (2024) 634 pp. 1238-1244 [ DOI: doi:10.1038/s41586-024-08012-9 Pubmed: 39358511 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Integral membrane protein gpr155 (99 kDa, Protein from Homo sapiens)
- Homodimeric complex of lychos (gpr155) (198 kDa, Complex from Homo sapiens)
The mTORC1 cholesterol sensor LYCHOS (GPR155)
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8u56
Q-score: 0.448
Bayly-Jones C, Lupton CJ, Keen AC, Dong S, Mastos C, Luo W, Qian C, Jones GD, Venugopal H, Chang YG, Clarke RJ, Halls ML, Ellisdon AM
Nature (2024) 634 pp. 1238-1244 [ DOI: doi:10.1038/s41586-024-08012-9 Pubmed: 39358511 ]
- Lauryl maltose neopentyl glycol (1 kDa, Ligand)
- Homodimeric complex of lychos (gpr155) - transmembrane region (198 kDa, Complex from Homo sapiens)
- Integral membrane protein gpr155 (99 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
The mTORC1 cholesterol sensor LYCHOS (GPR155) with tryptophan
Resolution: 2.45 Å
EM Method: Single-particle
Fitted PDBs: 8u58
Q-score: 0.42
Bayly-Jones C, Lupton CJ, Keen AC, Dong S, Mastos C, Luo W, Qian C, Jones GD, Venugopal H, Chang YG, Clarke RJ, Halls ML, Ellisdon AM
Nature (2024) 634 pp. 1238-1244 [ DOI: doi:10.1038/s41586-024-08012-9 Pubmed: 39358511 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Integral membrane protein gpr155 (99 kDa, Protein from Homo sapiens)
- Homodimeric complex of lychos (gpr155) (198 kDa, Complex from Homo sapiens)
The mTORC1 cholesterol sensor LYCHOS (GPR155) with cholesterol
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8u5c
Q-score: 0.496
Bayly-Jones C, Lupton CJ, Keen AC, Dong S, Mastos C, Luo W, Qian C, Jones GD, Venugopal H, Chang YG, Clarke RJ, Halls ML, Ellisdon AM
Nature (2024) 634 pp. 1238-1244 [ DOI: doi:10.1038/s41586-024-08012-9 Pubmed: 39358511 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Integral membrane protein gpr155 (99 kDa, Protein from Homo sapiens)
- Homodimeric complex of lychos (gpr155) (198 kDa, Complex from Homo sapiens)
The mTORC1 cholesterol sensor LYCHOS (GPR155) - monomer with auxin
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8u5n
Q-score: 0.315
Bayly-Jones C, Lupton CJ, Keen AC, Dong S, Mastos C, Luo W, Qian C, Jones GD, Venugopal H, Chang YG, Clarke RJ, Halls ML, Ellisdon AM
Nature (2024) 634 pp. 1238-1244 [ DOI: doi:10.1038/s41586-024-08012-9 Pubmed: 39358511 ]
- Integral membrane protein gpr155 (99 kDa, Protein from Homo sapiens)
- Monomer of lychos (gpr155) (99 kDa, Complex from Homo sapiens)
- 1h-indol-3-ylacetic acid (175 Da, Ligand)
The mTORC1 cholesterol sensor LYCHOS (GPR155) - dimer with auxin
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8u5q
Q-score: 0.498
Bayly-Jones C, Lupton CJ, Keen AC, Dong S, Mastos C, Luo W, Qian C, Jones GD, Venugopal H, Chang YG, Clarke RJ, Halls ML, Ellisdon AM
Nature (2024) 634 pp. 1238-1244 [ DOI: doi:10.1038/s41586-024-08012-9 Pubmed: 39358511 ]
- Integral membrane protein gpr155 (99 kDa, Protein from Homo sapiens)
- Monomer of lychos (gpr155) (99 kDa, Complex from Homo sapiens)
- 1h-indol-3-ylacetic acid (175 Da, Ligand)
The mTORC1 cholesterol sensor LYCHOS (GPR155) - auxin bound, closed state
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8u5v
Q-score: 0.494
Bayly-Jones C, Lupton CJ, Keen AC, Dong S, Mastos C, Luo W, Qian C, Jones GD, Venugopal H, Chang YG, Clarke RJ, Halls ML, Ellisdon AM
Nature (2024) 634 pp. 1238-1244 [ DOI: doi:10.1038/s41586-024-08012-9 Pubmed: 39358511 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Closed conformation of lychos (99 kDa, Complex from Homo sapiens)
- Integral membrane protein gpr155 (99 kDa, Protein from Homo sapiens)
- 1h-indol-3-ylacetic acid (175 Da, Ligand)
The mTORC1 cholesterol sensor LYCHOS (GPR155) - auxin bound, open state
Resolution: 2.79 Å
EM Method: Single-particle
Fitted PDBs: 8u5x
Q-score: 0.451
Bayly-Jones C, Lupton CJ, Keen AC, Dong S, Mastos C, Luo W, Qian C, Jones GD, Venugopal H, Chang YG, Clarke RJ, Halls ML, Ellisdon AM
Nature (2024) 634 pp. 1238-1244 [ DOI: doi:10.1038/s41586-024-08012-9 Pubmed: 39358511 ]
- Integral membrane protein gpr155 (99 kDa, Protein from Homo sapiens)
- Open conformation of lychos (99 kDa, Complex from Homo sapiens)
- 1h-indol-3-ylacetic acid (175 Da, Ligand)