Human amino acid transporter EAAT2
Kato T, Kusakizako T, Jin C, Zhou X, Ohgaki R, Quan L, Xu M, Okuda S, Kobayashi K, Yamashita K, Nishizawa T, Kanai Y, Nureki O
Nat Commun (2022) 13 [ DOI: 10.1038/s41467-022-32442-6 Pubmed: 35953475 ]
Image sets:
Inward-facing structure of human EAAT2 in the WAY213613-bound state
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 7vr7
Q-score: 0.553
Kato T, Kusakizako T, Jin C, Zhou X, Ohgaki R, Quan L, Xu M, Okuda S, Kobayashi K, Yamashita K, Nishizawa T, Kanai Y, Nureki O
Nat Commun (2022) 13 pp. 4714-4714 [ Pubmed: 35953475 DOI: doi:10.1038/s41467-022-32442-6 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- (2s)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid (415 Da, Ligand)
- Eaat2 (Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Excitatory amino acid transporter 2 (63 kDa, Protein from Homo sapiens)
Inward-facing structure of human EAAT2 in the substrate-free state
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 7vr8
Q-score: 0.431
Kato T, Kusakizako T, Jin C, Zhou X, Ohgaki R, Quan L, Xu M, Okuda S, Kobayashi K, Yamashita K, Nishizawa T, Kanai Y, Nureki O
Nat Commun (2022) 13 pp. 4714-4714 [ Pubmed: 35953475 DOI: doi:10.1038/s41467-022-32442-6 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Eaat2 (Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Excitatory amino acid transporter 2 (63 kDa, Protein from Homo sapiens)
LAT1-CD98hc bound to MEM-108 Fab
Lee Y, Wiriyasermkul P, Jin C, Quan L, Ohgaki R, Okuda S, Kusakizako T, Nishizawa T, Oda K, Ishitani R, Yokoyama T, Nakane T, Shirouzu M, Endou H, Nagamori S, Kanai Y, Nureki O
Nat. Struct. Mol. Biol. (2019) [ Pubmed: 31160781 DOI: 10.1038/s41594-019-0237-7 ]
Image sets:
LAT1-CD98hc complex bound to MEM-108 Fab
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 6jmq
Q-score: 0.487
Lee Y, Wiriyasermkul P, Jin C, Quan L, Ohgaki R, Okuda S, Kusakizako T, Nishizawa T, Oda K, Ishitani R, Yokoyama T, Nakane T, Shirouzu M, Endou H, Nagamori S, Kanai Y, Nureki O
Nat Struct Mol Biol (2019) 26 pp. 510-517 [ DOI: doi:10.1038/s41594-019-0237-7 Pubmed: 31160781 ]
- Lat1-cd98hc complex bound to mem-108 fab (175 MDa, Complex from Homo sapiens)
- Antibody (22 kDa, Protein from Mus musculus)
- Antibody (23 kDa, Protein from Mus musculus)
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Large neutral amino acids transporter small subunit 1 (56 kDa, Protein from Homo sapiens)
CD98hc extracellular domain bound to HBJ127 Fab and MEM-108 Fab
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 6jmr
Q-score: 0.398
Lee Y, Wiriyasermkul P, Jin C, Quan L, Ohgaki R, Okuda S, Kusakizako T, Nishizawa T, Oda K, Ishitani R, Yokoyama T, Nakane T, Shirouzu M, Endou H, Nagamori S, Kanai Y, Nureki O
Nat Struct Mol Biol (2019) 26 pp. 510-517 [ DOI: doi:10.1038/s41594-019-0237-7 Pubmed: 31160781 ]
- Antibody (22 kDa, Protein from Mus musculus)
- Antibody (24 kDa, Protein from Mus musculus)
- Antibody (23 kDa, Protein from Mus musculus)
- Antibody (23 kDa, Protein from Mus musculus)
- 4f2 cell-surface antigen heavy chain (68 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cd98hc extracellular domain bound to mem-108 fab and hbj127 fab (225 MDa, Complex from Homo sapiens)