Structure of human UCP1 in the nucleotide-free state
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 8hbv
Q-score: 0.629
Nature (2023) 620 pp. 226-231 [ Pubmed: 37336486 DOI: doi:10.1038/s41586-023-06332-w ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Ucp1-sybody complex (Complex from Homo sapiens)
- Mitochondrial brown fat uncoupling protein 1 (39 kDa, Protein from Homo sapiens)
- Sybody 12f2 (15 kDa, Protein from synthetic construct)
Structure of human UCP1 in the ATP-bound state
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 8hbw
Q-score: 0.644
Nature (2023) 620 pp. 226-231 [ Pubmed: 37336486 DOI: doi:10.1038/s41586-023-06332-w ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Ucp1-sybody complex (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Mitochondrial brown fat uncoupling protein 1 (39 kDa, Protein from Homo sapiens)
- Sybody 12f2 (15 kDa, Protein from synthetic construct)
Structure of human UCP1 in the DNP-bound state
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 8j1n
Q-score: 0.608
Nature (2023) 620 pp. 226-231 [ Pubmed: 37336486 DOI: doi:10.1038/s41586-023-06332-w ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- 2,4-dinitrophenol (184 Da, Ligand)
- Ucp1-sybody complex (Complex from Homo sapiens)
- Mitochondrial brown fat uncoupling protein 1 (39 kDa, Protein from Homo sapiens)
- Sybody 12f2 (15 kDa, Protein from synthetic construct)
Structure of human soluble guanylate cyclase in the NO activated state
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6jt2
Q-score: 0.411
Nature (2019) 574 pp. 206-210 [ Pubmed: 31514202 DOI: doi:10.1038/s41586-019-1584-6 ]
- Magnesium ion (24 Da, Ligand)
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
Structure of human soluble guanylate cyclase in the unliganded state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6jt0
Q-score: 0.357
Nature (2019) 574 pp. 206-210 [ DOI: doi:10.1038/s41586-019-1584-6 Pubmed: 31514202 ]
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
Structure of human soluble guanylate cyclase in the heme oxidised state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6jt1
Q-score: 0.436
Nature (2019) 574 pp. 206-210 [ Pubmed: 31514202 DOI: doi:10.1038/s41586-019-1584-6 ]
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
human soluble guanylate cyclase H105C mutant
Nature (2019) 574 pp. 206-210 [ Pubmed: 31514202 DOI: doi:10.1038/s41586-019-1584-6 ]
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6cmo
Q-score: 0.315
Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE
Nature (2018) 558 pp. 553-558 [ DOI: doi:10.1038/s41586-018-0215-y Pubmed: 29899450 ]
- Fab heavy chain (25 kDa, Protein from synthetic construct)
- Chimera protein of soluble cytochrome b562 and rhodopsin (52 kDa, Protein from Homo sapiens)
- Protein complex of rhodopsin with galphai (180 MDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Fab light chain (23 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)