Structure of human UCP1 in the nucleotide-free state
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 8hbv
Q-score: 0.629
Nature (2023) 620 pp. 226-231 [ Pubmed: 37336486 DOI: doi:10.1038/s41586-023-06332-w ]
- Sybody 12f2 (15 kDa, Protein from synthetic construct)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Ucp1-sybody complex (Complex from Homo sapiens)
- Mitochondrial brown fat uncoupling protein 1 (39 kDa, Protein from Homo sapiens)
- Cardiolipin (1 kDa, Ligand)
Structure of human UCP1 in the ATP-bound state
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 8hbw
Q-score: 0.644
Nature (2023) 620 pp. 226-231 [ Pubmed: 37336486 DOI: doi:10.1038/s41586-023-06332-w ]
- Sybody 12f2 (15 kDa, Protein from synthetic construct)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Ucp1-sybody complex (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Mitochondrial brown fat uncoupling protein 1 (39 kDa, Protein from Homo sapiens)
- Cardiolipin (1 kDa, Ligand)
Structure of human UCP1 in the DNP-bound state
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 8j1n
Q-score: 0.608
Nature (2023) 620 pp. 226-231 [ Pubmed: 37336486 DOI: doi:10.1038/s41586-023-06332-w ]
- Sybody 12f2 (15 kDa, Protein from synthetic construct)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2,4-dinitrophenol (184 Da, Ligand)
- Ucp1-sybody complex (Complex from Homo sapiens)
- Mitochondrial brown fat uncoupling protein 1 (39 kDa, Protein from Homo sapiens)
- Cardiolipin (1 kDa, Ligand)
Structure of human soluble guanylate cyclase in the NO activated state
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6jt2
Q-score: 0.411
Nature (2019) 574 pp. 206-210 [ DOI: doi:10.1038/s41586-019-1584-6 Pubmed: 31514202 ]
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
Structure of human soluble guanylate cyclase in the unliganded state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6jt0
Q-score: 0.357
Nature (2019) 574 pp. 206-210 [ DOI: doi:10.1038/s41586-019-1584-6 Pubmed: 31514202 ]
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
Structure of human soluble guanylate cyclase in the heme oxidised state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6jt1
Q-score: 0.436
Nature (2019) 574 pp. 206-210 [ DOI: doi:10.1038/s41586-019-1584-6 Pubmed: 31514202 ]
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6cmo
Q-score: 0.315
Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE
Nature (2018) 558 pp. 553-558 [ DOI: doi:10.1038/s41586-018-0215-y Pubmed: 29899450 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Fab light chain (23 kDa, Protein from synthetic construct)
- Protein complex of rhodopsin with galphai (180 MDa, Complex from Homo sapiens)
- Fab heavy chain (25 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Chimera protein of soluble cytochrome b562 and rhodopsin (52 kDa, Protein from Homo sapiens)