CryoEM structure of human alpha4beta2 nicotinic acetylcholine receptor in complex with varenicline
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 6ur8
Q-score: 0.448
Mukherjee S, Erramilli SK, Ammirati M, Alvarez FJD, Fennell KF, Purdy MD, Skrobek BM, Radziwon K, Coukos J, Kang Y, Dutka P, Gao X, Qiu X, Yeager M, Eric Xu H, Han S, Kossiakoff AA
Nat Commun (2020) 11 pp. 1598-1598 [ Pubmed: 32221310 DOI: doi:10.1038/s41467-020-15363-0 ]
- Beta-d-mannopyranose (180 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Varenicline (211 Da, Ligand)
- Chimera of soluble cytochrome b562 (bril) and neuronal acetylcholine receptor subunit alpha-4 (56 kDa, Protein from Homo sapiens)
- Human alpha4beta2 nicotinic acetylcholine receptor in complex fab fragments and bound to varenicline (Complex from Homo sapiens)
- Neuronal acetylcholine receptor subunit beta-2 (45 kDa, Protein from Homo sapiens)
Resolution: 3.87 Å
EM Method: Single-particle
Fitted PDBs: 6usf
Q-score: 0.394
Mukherjee S, Erramilli SK, Ammirati M, Alvarez FJD, Fennell KF, Purdy MD, Skrobek BM, Radziwon K, Coukos J, Kang Y, Dutka P, Gao X, Qiu X, Yeager M, Eric Xu H, Han S, Kossiakoff AA
Nat Commun (2020) 11 pp. 1598-1598 [ Pubmed: 32221310 DOI: doi:10.1038/s41467-020-15363-0 ]
- Beta-d-mannopyranose (180 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab light chain (23 kDa, Protein from Homo sapiens)
- Fab heavy chain (24 kDa, Protein from Homo sapiens)
- Varenicline (211 Da, Ligand)
- Chimera of soluble cytochrome b562 (bril) and neuronal acetylcholine receptor subunit alpha-4 (55 kDa, Protein from Homo sapiens)
- Human alpha4beta2 nicotinic acetylcholine receptor in complex fab fragments and bound to varenicline (Complex from Homo sapiens)
- Neuronal acetylcholine receptor subunit beta-2 (45 kDa, Protein from Homo sapiens)
Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 6omm
Q-score: 0.451
Zhuang Y, Liu H, Edward Zhou X, Kumar Verma R, de Waal PW, Jang W, Xu TH, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert NA, Eric Xu H, Zhang C
Nat Commun (2020) 11 pp. 885-885 [ Pubmed: 32060286 DOI: doi:10.1038/s41467-020-14728-9 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- N-formyl peptide receptor 2 (40 kDa, Protein from Homo sapiens)
- Fpr2-gi complex (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Peptide agonist (857 Da, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)