Structure of human UCP1 in the nucleotide-free state
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 8hbv
Q-score: 0.629
Nature (2023) 620 pp. 226-231 [ Pubmed: 37336486 DOI: doi:10.1038/s41586-023-06332-w ]
- Sybody 12f2 (15 kDa, Protein from synthetic construct)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Ucp1-sybody complex (Complex from Homo sapiens)
- Mitochondrial brown fat uncoupling protein 1 (39 kDa, Protein from Homo sapiens)
- Cardiolipin (1 kDa, Ligand)
Structure of human UCP1 in the ATP-bound state
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 8hbw
Q-score: 0.644
Nature (2023) 620 pp. 226-231 [ Pubmed: 37336486 DOI: doi:10.1038/s41586-023-06332-w ]
- Sybody 12f2 (15 kDa, Protein from synthetic construct)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Ucp1-sybody complex (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Mitochondrial brown fat uncoupling protein 1 (39 kDa, Protein from Homo sapiens)
- Cardiolipin (1 kDa, Ligand)
Structure of human UCP1 in the DNP-bound state
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 8j1n
Q-score: 0.608
Nature (2023) 620 pp. 226-231 [ Pubmed: 37336486 DOI: doi:10.1038/s41586-023-06332-w ]
- Sybody 12f2 (15 kDa, Protein from synthetic construct)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 2,4-dinitrophenol (184 Da, Ligand)
- Ucp1-sybody complex (Complex from Homo sapiens)
- Mitochondrial brown fat uncoupling protein 1 (39 kDa, Protein from Homo sapiens)
- Cardiolipin (1 kDa, Ligand)
Structure of human soluble guanylate cyclase in the inactive state at 3.1 angstrom
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8hbe
Q-score: 0.526
Nitric Oxide (2023) 134-135 pp. 17-22 [ Pubmed: 36972843 DOI: doi:10.1016/j.niox.2023.03.002 ]
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
Structure of human soluble guanylate cyclase in the NO+Rio state at 3.1 angstrom
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8hbf
Q-score: 0.539
Nitric Oxide (2023) 134-135 pp. 17-22 [ Pubmed: 36972843 DOI: doi:10.1016/j.niox.2023.03.002 ]
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Methyl ~{n}-[4,6-bis(azanyl)-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]-~{n}-methyl-carbamate (422 Da, Ligand)
- Nitric oxide (30 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
Structure of human soluble guanylate cyclase in the NO-activated state at 3.1 angstrom
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8hbh
Q-score: 0.537
Nitric Oxide (2023) 134-135 pp. 17-22 [ Pubmed: 36972843 DOI: doi:10.1016/j.niox.2023.03.002 ]
- Phosphomethylphosphonic acid guanylate ester (521 Da, Ligand)
- Guanylate cyclase soluble subunit alpha-1 (77 kDa, Protein from Homo sapiens)
- Human soluble guanylate cyclase (Complex from Homo sapiens)
- Nitric oxide (30 Da, Ligand)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanylate cyclase soluble subunit beta-1 (70 kDa, Protein from Homo sapiens)
Molecular mechanism of the the wake-promoting agent TAK-925
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7sr8
Q-score: 0.457
Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM
Nat Commun (2022) 13 pp. 2902-2902 [ Pubmed: 35614071 DOI: doi:10.1038/s41467-022-30601-3 ]
- A modified guanine nucleotide-binding protein g(q) subunit alpha (27 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Oleic acid (282 Da, Ligand)
- Human orexin receptor 2 - g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Hypocretin receptor type 2 (46 kDa, Protein from Homo sapiens)
- Methyl (2r,3s)-3-[(methanesulfonyl)amino]-2-({[(1s,4s)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate (424 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
Structure of the orexin-2 receptor (OX2R) bound to TAK-925, Gi and scFv16
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 7sqo
Q-score: 0.487
Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM
Nat Commun (2022) 13 pp. 2902-2902 [ Pubmed: 35614071 DOI: doi:10.1038/s41467-022-30601-3 ]
- Orexin receptor type 2 (Complex from Homo sapiens)
- Human ox2r in complex with gai/gb/gg-scfv16. (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Oleic acid (282 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Bos taurus)
- Scfv-16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (Complex from Homo sapiens)
- Methyl (2r,3s)-3-[(methanesulfonyl)amino]-2-({[(1s,4s)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate (424 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Orexin receptor type 2 (50 kDa, Protein from Homo sapiens)
- Scfv-16 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Bos taurus)
Structure of Mammalian NALCN-FAM155A-UNC79-UNC80 quanternary complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7w7g
Q-score: 0.42
Nat Commun (2022) 13 pp. 2639-2639 [ Pubmed: 35550517 DOI: doi:10.1038/s41467-022-30403-7 ]
- Sodium leak channel non-selective protein (200 kDa, Protein from Rattus norvegicus)
- Protein unc-80 homolog (371 kDa, Protein from Mus musculus)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Protein unc-79 homolog (297 kDa, Protein from Mus musculus)
- Nalcn-fam155a-unc79-unc80 complex (Complex from Mus musculus)
- Transmembrane protein fam155a (52 kDa, Protein from Mus musculus)
Structure of TRPC3 at 2.7 angstrom in high calcium state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7dxb
Q-score: 0.56
Guo W, Tang Q, Wei M, Kang Y, Wu JX, Chen L
Neuron (2022) 110 pp. 1023-1035.e5 [ DOI: doi:10.1016/j.neuron.2021.12.023 Pubmed: 35051376 ]
- Short transient receptor potential channel 3 (96 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- [(2s)-2-[(e)-octadec-10-enoyl]oxy-3-oxidanyl-propyl] octadec-10-enoate (620 Da, Ligand)
- Human transient receptor potential channel 3 tetramer (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)